59 research outputs found
Simultaneous surface acoustic wave and surface plasmon resonance measurements: electrodeposition and biological interactions monitoring
We present results from an instrument combining surface acoustic wave (SAW)
propagation and surface plasmon resonance (SPR) measurements. The objective is
to use two independent methods, the former based on adsorbed mass change
measurements and the latter on surface dielectric properties variations, to
identify physical properties of protein layers, and more specifically their
water content. We display mass sensitivity calibration curves using
electrodeposition of copper leading to a sensitivity in liquid of 150
for the Love mode device used here, and the application to monitoring
biological processes. The extraction of protein layer thickness and protein to
water content ratio is also presented for S-layer proteins under investigation.
We obtain respectively 4.70.7 nm and 7515%.Comment: 13 pages, 4 figure
Occupational Therapy Intervention with Children Survivors of War
A preventive occupational therapy program with children surviving the Kosovo
conflict is examined. The objective of the program was to facilitate the emotional
expression of traumatic experiences in order to prevent the development of future
psychological problems. The intervention was based on a community-centred
approach with spirituality as a central focus of the intervention.The Model of Human
Occupation and the Occupational Performance Process Model were utilized to guide
the identification and intervention of occupational performance issues.The children’s
return from a land of war to a land of children demonstrates the potential of occupational
therapy intervention in this field. With increasing awareness of populations
facing social and political challenges, there is a growing importance of the concept of
occupational justice and the need to work against occupational apartheid.Cet article décrit un programme de prévention en ergothérapie qui était destiné aux
enfants ayant survécu au conflit du Kosovo. L’objectif du programme était d’aider
les enfants à exprimer les émotions qu’ils avaient ressenties lors d’expériences
traumatiques afin de prévenir l’apparition de problèmes psychologiques.
L’intervention était basée sur une approche communautaire s’articulant autour de
la spiritualité. Le Modèle de l’occupation humaine et le Modèle du processus
d’intervention dans le rendement occupationnel ont été utilisés pour cibler les
difficultés en matière de rendement occupationnel et pour déterminer les
interventions requises. Le retour des enfants d’un monde de guerre vers le monde de
l’enfance démontre la possibilité de proposer une intervention ergothérapique
dans ce domaine. La conscientisation de plus en plus grand face à la détresse des
populations confrontées à des problèmes politiques et sociaux entraîne une
augmentation de l’importance du concept de la justice occupationnelle et du besoin
de lutter contre l’apartheid occupationnel
Comparative Study on the Therapeutic Potential of Neurally Differentiated Stem Cells in a Mouse Model of Multiple Sclerosis
Background: Transplantation of neural stem cells (NSCs) is a promising novel approach to the treatment of neuroinflammatory diseases such as multiple sclerosis (MS). NSCs can be derived from primary central nervous system (CNS) tissue or obtained by neural differentiation of embryonic stem (ES) cells, the latter having the advantage of readily providing an unlimited number of cells for therapeutic purposes. Using a mouse model of MS, we evaluated the therapeutic potential of NSCs derived from ES cells by two different neural differentiation protocols that utilized adherent culture conditions and compared their effect to primary NSCs derived from the subventricular zone (SVZ). Methodology/Principal Findings: The proliferation and secretion of pro-inflammatory cytokines by antigen-stimulated splenocytes was reduced in the presence of SVZ-NSCs, while ES cell-derived NSCs exerted differential immunosuppressive effects. Surprisingly, intravenously injected NSCs displayed no significant therapeutic impact on clinical and pathological disease outcomes in mice with experimental autoimmune encephalomyelitis (EAE) induced by recombinant myelin oligodendrocyte glycoprotein, independent of the cell source. Studies tracking the biodistribution of transplanted ES cellderived NSCs revealed that these cells were unable to traffic to the CNS or peripheral lymphoid tissues, consistent with the lack of cell surface homing molecules. Attenuation of peripheral immune responses could only be achieved through multiple high doses of NSCs administered intraperitoneally, which led to some neuroprotective effects within the CNS
Multistage Quadrature Sigma-Delta Modulators for Reconfigurable Multi-Band Analog-Digital Interface in Cognitive Radio Devices
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