An Exploration of Tropical Cyclone Simulations in NCAR's Community Atmosphere Model.

Using General Circulation Models (GCMs) for tropical cyclone studies is challenging due to the relatively small size of the storms, the intense convection and a host of scale interactions. However, with the advancement of computer architectures, GCMs are becoming capable of running at high horizontal resolutions with grid spacings of less than 60 km. As a result, high-resolution GCMs are becoming a tool of choice to evaluate tropical cyclones in current and future climate conditions. This raises questions concerning the fidelity of GCMs for tropical cyclone assessments. The physical and dynamical components of GCMs need to be evaluated to assess their reliability for tropical cyclone studies. An idealized tropical cyclone test case for high-resolution GCMs is developed and implemented in aqua-planet mode with constant sea surface temperatures. The initial conditions are based on an analytic initial vortex seed that is in gradient-wind and hydrostatic balance and intensifies over a 10-day period. The influence of the model parameterization package on the development of the tropical cyclone is assessed. In particular, different physics parameterization suites are investigated within the National Center for Atmospheric Research's Community Atmosphere Model CAM, including physics versions 3.1, 4 and 5. The choice of the CAM physics suite has a significant impact on the evolution of the idealized vortex into a tropical cyclone. In addition, a test case of intermediate complexity is introduced. Therein it is suggested that a GCM dynamical core be paired with simple moist physics to test the evolution of the test vortex. This simple-physics configuration includes important driving mechanisms for tropical cyclones, including surface fluxes, boundary layer diffusion and large-scale condensation. The impact of the CAM dynamical core (the resolved fluid flow component) on the tropical cyclone intensity and size is evaluated. In particular, the finite-volume, spectral element, Eulerian spectral transform and semi-Lagrangian spectral transform dynamical cores are utilized. The simple-physics simulations capture the dominant characteristics of tropical cyclones and are compared to the CAM 5 full physics results for each dynamical core. The research isolates the impact of the physical parameterizations, numerical schemes and uncertainties on the evolution of the cyclone in CAM.Ph.D.Atmospheric and Space SciencesUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/91502/1/kareed_1.pd

Analytic Considerations in Economic Evaluations of Multinational Cardiovascular Clinical Trials

OBJECTIVES: The growing number of economic evaluations that use data collected in multinational clinical trials raises numerous questions regarding their execution and interpretation. Although recommendations for conducting economic evaluations have been widely disseminated, relatively little guidance has been given for conducting economic evaluations alongside clinical trials, particularly multinational trials. METHODS: Building on a literature review that was conducted in preparation for an expert workshop, we evaluated a subset of methodological issues related to conducting economic evaluations alongside multinational clinical trials. RESULTS: We found wide variation in the types of costs included as part of the analyses and in the methods used to assign costs to hospitalization events. Furthermore, we found that the extrapolation of costs and survival outcomes beyond the trial period is an inconsistent practice and is often not dependent on whether a survival benefit was observed in the trial or on the epidemiology or practice patterns in the country to which the findings are directed. CONCLUSIONS: Although the limited sample size precluded a quantitative analysis of trial characteristics and their associations with the methodologies employed, our findings highlight the need for more guidance to analysts regarding the execution of economic evaluations using data from multinational clinical trials. As the research community grapples with the complexities of methodological and logistical issues involved in multinational economic evaluations, the development of a standardized format to report the basic methodological characteristics of such studies would help to improve transparency and comparability for other analysts and decision-makers

Algae: Feedstock for Biofuels and Biochemicals

Biomass energy is a great alternative for replacing fossil fuel demands. It has a lot of advantages such as producing clean energy, being renewable and creating a sustainable planet. But, there is no perfect energy source in this world. It also has some disadvantages

Calibrations of phase abundance, composition, and particle size distribution for olivine-orthopyroxene mixtures from reflectance spectra

Spectral reflectance measurements of characterized (phase abundance, particle size) mixtures of olivine and orthopyroxene were utilized to define the correlations between spectral and albedo parameters of such assemblages and their mineralogical or textural properties. Thirty-three different spectral parameters falling into three general classes (relative or ratioed, absolute or albedo, and wavelength) were investigated for empirical sensitivity to one or more of the mixture properties. Theoretical considerations and previous experimental observations were utilized to understand their functional relationships. The ratio of areas for the 1- and 2-3µm absorption bands is shown to be a sensitive indicator of the olivine-orthopyroxene abundance and is very nearly independent of particle size and mineral composition. In conjunction with an abundance determination, the wavelength position of the 1-3tm absorption feature can be utilized to determine the molar iron contents of the olivine and orthopyroxene phases. This calibration is insensitive to particle size but will produce systematic deviations if the phases have significantly different iron contents or if more than a few percent of a clinopyroxene component is present. The spectral albedo in the 0.6- to 0.7-µm region is relatively insensitive to phase abundance and can be used to constrain particle size if phase composition has been determinedVarious portions of this work were supported at the University of Hawaii by NASA grant NSG-7312 and by a Sigma Xi Foundation grant to E.A.C. and at Rensselaer Polytechnic Institute by NASA grant NAGW-642. Planetary Geosciences Division, Hawaii Institute of Geophysics, University of Hawaii, publication4 70

“We Just Don’t Have the Possibility Yet”: U.S. Latina/o Narratives on Study Abroad

Whether indirectly from governmental and non-governmental organizations or directly from higher education institutions, students receive messages that they should study abroad. Studying in a foreign country is considered essential if students are to be marketable to future employers and prepared to lead the U.S. into a new era. Despite the presence of such messages, the understanding of what it means to be absent from the undergraduate student population willing and able to study in a foreign country is severely limited. Importantly, what are the perceptions and experiences of students who repeatedly hear the value of study abroad and who, at the same time, are not willing and/or able to participate? The purpose of this critical qualitative study was to seek answers to this question by exploring the perceptions and experiences of a population that continues to experience low rates of study abroad participation: Latina/o undergraduate students

A Preliminary Investigation towards the Risk Stratification of Allogeneic Stem Cell Recipients with Respect to the Potential for Development of GVHD via Their Pre-Transplant Plasma Lipid and Metabolic Signature

The clinical outcome of allogeneic hematopoietic stem cell transplantation (SCT) may be influenced by the metabolic status of the recipient following conditioning, which in turn may enable risk stratification with respect to the development of transplant-associated complications such as graft vs. host disease (GVHD). To better understand the impact of the metabolic profile of transplant recipients on post-transplant alloreactivity, we investigated the metabolic signature of 14 patients undergoing myeloablative conditioning followed by either human leukocyte antigen (HLA)-matched related or unrelated donor SCT, or autologous SCT. Blood samples were taken following conditioning and prior to transplant on day 0 and the plasma was comprehensively characterized with respect to its lipidome and metabolome via liquid chromatography/mass spectrometry (LCMS) and gas chromatography/mass spectrometry (GCMS). A pro-inflammatory metabolic profile was observed in patients who eventually developed GVHD. Five potential pre-transplant biomarkers, 2-aminobutyric acid, 1-monopalmitin, diacylglycerols (DG 38:5, DG 38:6), and fatty acid FA 20:1 demonstrated high sensitivity and specificity towards predicting post-transplant GVHD. The resulting predictive model demonstrated an estimated predictive accuracy of risk stratification of 100%, with area under the curve of the ROC of 0.995. The likelihood ratio of 1-monopalmitin (infinity), DG 38:5 (6.0), and DG 38:6 (6.0) also demonstrated that a patient with a positive test result for these biomarkers following conditioning and prior to transplant will be at risk of developing GVHD. Collectively, the data suggest the possibility that pre-transplant metabolic signature may be used for risk stratification of SCT recipients with respect to development of alloreactivity

Parents' reported preference scores for childhood atopic dermatitis disease states

BACKGROUND: We sought to elicit preference weights from parents for health states corresponding to children with various levels of severity of atopic dermatitis. We also evaluated the hypothesis that parents with children who had been diagnosed with atopic dermatitis would assign different preferences to the health state scenarios compared with parents who did not have a child with atopic dermatitis. METHODS: Subjects were parents of children aged 3 months to 18 years. The sample was derived from the General Panel, Mommies Sub-Panel, and Chronic Illness Sub-Panel of Harris Interactive. Participants rated health scenarios for atopic dermatitis, asthma, and eyeglasses on a visual analog scale, imagining a child was experiencing the described state. RESULTS: A total of 3539 parents completed the survey. Twenty-nine percent had a child with a history of atopic dermatitis. Mean preference scores for atopic dermatitis were as follows: mild, 91 (95% confidence interval [CI], 90.7 to 91.5); mild/moderate, 84 (95%CI, 83.5 to 84.4); moderate, 73 (95%CI, 72.5 to 73.6); moderate/severe, 61 (95%CI, 60.6 to 61.8); severe, 49 (95% CI, 48.7 to 50.1); asthma, 58 (95%CI, 57.4 to 58.8); and eyeglasses, 87(95%CI, 86.3 to 87.4). CONCLUSIONS: Parents perceive that atopic dermatitis has a negative effect on quality of life that increases with disease severity. Estimates of parents' preferences can provide physicians with insight into the value that parents place on their children's treatment and can be used to evaluate new medical therapies for atopic dermatitis