2,130 research outputs found
Single-Pill Combination with Three Antihypertensive Agents to Improve Blood Pressure Control in Hypertension: Focus on Olmesartan-Based Combinations.
Blood pressure control remains an unmet clinical need. Only about half of patients achieve their blood pressure (BP) targets and of these, the majority require combination and double or triple therapies. International guidelines recommend the association of drugs with complementary mechanisms of action and, in particular, the combination of renin-angiotensin system (RAS) inhibitors, calcium channel blockers (CCBs), and diuretics. Among the various angiotensin receptor blockers, olmesartan (OM) is available as a monotherapy and in dual and triple single-pill combinations (SPCs) with amlodipine (AML) and/or hydrochlorothiazide (HCTZ). Several phase III and IV studies, together with real-world studies, have demonstrated the additional benefits of combining OM either with AML or with HCTZ in terms of BP control and target BP achievements both in the general population and in special subgroups of hypertensive patients, such as the elderly, diabetic, chronic kidney disease or obese patients. Ambulatory BP monitoring studies assessing 24h BP have also demonstrated that dual, as well as triple, OM-based SPCs induce a more sustained and smoother BP reduction than placebo and monotherapy. Furthermore, triple OM-based SPC has been shown to improve therapeutic adherence in hypertensive patients compared to free combinations. The availability of OM combined with HCTZ, AML or both at different dosages makes it a valuable option to customize therapy based on the levels of BP and the clinical characteristics of hypertensive patients
High-spin structures of 88Kr and 89Rb: Evolution from collective to single-particle behaviors
The high-spin states of the two neutron-rich nuclei, 88Kr and 89R have been
studied from the 18O + 208Pb fusion-fission reaction. Their level schemes were
built from triple gamma-ray coincidence data and gamma-gamma angular
correlations were analyzed in order to assign spin and parity values to most of
the observed states. The two levels schemes evolve from collective structures
to single-particle excitations as a function of the excitation energy.
Comparison with results of shell-model calculations gives the specific proton
and neutron configurations which are involved to generate the angular momentum
along the yrast lines.Comment: 12 pages, 9 figures, Physical Review C (2013) in pres
High-spin structures of 136Cs
Odd-odd 136Cs nuclei have been produced in the 18O + 208Pb and 12C + 238U
fusion-fission reactions and their gamma rays studied with the Euroball array.
The high-spin level scheme has been built up to ~ 4.7 MeV excitation energy and
spin I ~ 16 hbar from the triple gamma-ray coincidence data. The configurations
of the three structures observed above ~ 2 MeV excitation energy are first
discussed by analogy with the proton excitations identified in the semi-magic
137Cs nucleus, which involve the three high-j orbits lying above the Z=50 gap,
pi g_{7/2}, pi d_{5/2} and pi h_{11/2}. This is confirmed by the results of
shell-model calculations performed in this work.Comment: 6 pages, 4 figures, 3 table
High Performance Algorithms for Counting Collisions and Pairwise Interactions
The problem of counting collisions or interactions is common in areas as
computer graphics and scientific simulations. Since it is a major bottleneck in
applications of these areas, a lot of research has been carried out on such
subject, mainly focused on techniques that allow calculations to be performed
within pruned sets of objects. This paper focuses on how interaction
calculation (such as collisions) within these sets can be done more efficiently
than existing approaches. Two algorithms are proposed: a sequential algorithm
that has linear complexity at the cost of high memory usage; and a parallel
algorithm, mathematically proved to be correct, that manages to use GPU
resources more efficiently than existing approaches. The proposed and existing
algorithms were implemented, and experiments show a speedup of 21.7 for the
sequential algorithm (on small problem size), and 1.12 for the parallel
proposal (large problem size). By improving interaction calculation, this work
contributes to research areas that promote interconnection in the modern world,
such as computer graphics and robotics.Comment: Accepted in ICCS 2019 and published in Springer's LNCS series.
Supplementary content at https://mjsaldanha.com/articles/1-hpc-ssp
Evolution of shell structure in neutron-rich calcium isotopes
We employ interactions from chiral effective field theory and compute the
binding energies and low-lying excitations of calcium isotopes with the
coupled-cluster method. Effects of three-nucleon forces are included
phenomenologically as in-medium two-nucleon interactions, and the coupling to
the particle continuum is taken into account using a Berggren basis. The
computed ground-state energies and the low-lying 2+ states for the isotopes
42,48,50,52Ca are in good agreement with data, and we predict the excitation
energy of the first 2+ state in 54Ca at 1.9 MeV, displaying only a weak
sub-shell closure. In the odd-mass nuclei 53,55,61Ca we find that the positive
parity states deviate strongly from the naive shell model.Comment: 5 pages, 4 figures; small correction of effective 3NF and slight
change of the corresponding parameters; updated figures and tables; main
results and conclusions unchange
High-spin states with seniority v=4,4,6 in 119-126Sn
The 119-126Sn nuclei have been produced as fission fragments in two reactions
induced by heavy ions: 12C+238U at 90 MeV bombarding energy, 18O+208Pb at 85
MeV. Their level schemes have been built from gamma rays detected using the
Euroball array. High-spin states located above the long-lived isomeric states
of the even- and odd-A 120-126Sn nuclei have been identified. Moreover isomeric
states lying around 4.5 MeV have been established in 120,122,124,126Sn from the
delayed coincidences between the fission fragment detector SAPhIR and the
Euroball array. The states located above 3-MeV excitation energy are ascribed
to several broken pairs of neutrons occupying the nu h11/2 orbit. The maximum
value of angular momentum available in such a high-j shell, i.e. for
mid-occupation and the breaking of the three neutron pairs, has been
identified. This process is observed for the first time in spherical nuclei.Comment: 20 pages, 22 figures, 12 tables, accepted for publication in Physical
Review
Dewetting of Glassy Polymer Films
Dynamics and morphology of hole growth in a film of power hardening
viscoplastic solid (yield stress ~ [strain-rate]^n) is investigated. At
short-times the growth is exponential and depends on the initial hole size. At
long-times, for n > 1/3, the growth is exponential with a different exponent.
However, for n < 1/3, the hole growth slows; the hole radius approaches an
asymptotic value as time tends to infinity. The rim shape is highly asymmetric,
the height of which has a power law dependence on the hole radius (exponent
close to unity for 0.25 < n < 0.4). The above results explain recent intriguing
experiments of Reiter, Phys. Rev. Lett, 87, 186101 (2001).Comment: 4 pages, 5 figures, RevTe
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