4 research outputs found

    Teacher Perceptions of Advanced Ability English Language Learners (ELL)

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    This study explored teacher perceptions of English language learners and giftedness. High school content teachers participated in an interview identifying behaviors that indicate advanced abilities from a series of three vignettes about English language learners. A total of four participants were interviewed. The four emergent themes were (1) critical thinking (2) rate of language acquisition, (3) motivation, and (4) use of language. The themes were behaviors that teachers perceived as demonstrating potential or demonstrating limited potential for advanced learning in English language learners

    Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination

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    Myelination occurs selectively around neuronal axons to increase the efficiency and velocity of action potentials. While oligodendrocytes are capable of myelinating permissive structures in the absence of molecular cues, structurally permissive neuronal somata and dendrites remain unmyelinated. Utilizing a purified spinal cord neuron-oligodendrocyte myelinating coculture system, we demonstrate that disruption of dynamic neuron-oligodendrocyte signaling by chemical crosslinking results in aberrant myelination of the somatodendritic compartment of neurons. We hypothesize that an inhibitory somatodendritic cue is necessary to prevent non-axonal myelination. Using next-generation sequencing and candidate profiling, we identify neuronal Junction Adhesion Molecule 2 (JAM2) as an inhibitory myelin-guidance molecule. Taken together, our results demonstrate that the somatodendritic compartment directly inhibits myelination, and suggest a model in which broadly indiscriminate myelination is tailored by inhibitory signaling to meet local myelination requirements
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