Advanced Glycation End Products in Health and Disease

Advanced glycation end products (AGEs), formed through the nonenzymatic reaction of reducing sugars with the side-chain amino groups of lysine or arginine of proteins, followed by further glycoxidation reactions under oxidative stress conditions, are involved in the onset and exacerbation of a variety of diseases, including diabetes, atherosclerosis, and Alzheimer\u27s disease (AD) as well as in the secondary stages of traumatic brain injury (TBI). AGEs, in the form of intra- and interprotein crosslinks, deactivate various enzymes, exacerbating disease progression. The interactions of AGEs with the receptors for the AGEs (RAGE) also result in further downstream inflammatory cascade events. The overexpression of RAGE and the AGE-RAGE interactions are especially involved in cases of Alzheimer\u27s disease and other neurodegenerative diseases, including TBI and amyotrophic lateral sclerosis (ALS). Maillard reactions are also observed in the gut bacterial species. The protein aggregates found in the bacterial species resemble those of AD and Parkinson\u27s disease (PD), and AGE inhibitors increase the life span of the bacteria. Dietary AGEs alter the gut microbiota composition and elevate plasma glycosylation, thereby leading to systemic proinflammatory effects and endothelial dysfunction. There is emerging interest in developing AGE inhibitor and AGE breaker compounds to treat AGE-mediated pathologies, including diabetes and neurodegenerative diseases. Gut-microbiota-derived enzymes may also function as AGE-breaker biocatalysts. Thus, AGEs have a prominent role in the pathogenesis of various diseases, and the AGE inhibitor and AGE breaker approach may lead to novel therapeutic candidates

The first example of direct oxidation of sulfides to sulfones by an osmate molecular oxygen system

Osmate-exchanged Mg-Al layered double hydroxides catalysed the delivery of two oxygen atoms simultaneously via a 3 + 1 cycloaddition to sulfide to form sulfone directly for the first time, reminiscent of 3 + 2 cycloaddition in asymmetric dihydroxylation reactions

Imidazolium-Based Polymeric Materials as Alkaline Anion-Exchange Fuel Cell Membranes

Polymer electrolyte membranes that conduct hydroxide ions have potential use in fuel cells. A variety of polystyrene-based quaternary ammonium hydroxides have been reported as anion exchange fuel cell membranes. However, the hydrolytic stability and conductivity of the commercially available membranes are not adequate to meet the requirements of fuel cell applications. When compared with commercially available membranes, polystyrene-imidazolium alkaline membrane electrolytes are more stable and more highly conducting. At the time of this reporting, this has been the first such usage for imidazolium-based polymeric materials for fuel cells. Imidazolium salts are known to be electrochemically stable over wide potential ranges. By controlling the relative ratio of imidazolium groups in polystyrene-imidazolium salts, their physiochemical properties could be modulated. Alkaline anion exchange membranes based on polystyrene-imidazolium hydroxide materials have been developed. The first step was to synthesize the poly(styrene-co-(1-((4-vinyl)methyl)-3- methylimidazolium) chloride through a free-radical polymerization. Casting of this material followed by in situ treatment of the membranes with sodium hydroxide solutions provided the corresponding hydroxide salts. Various ratios of the monomers 4-chloromoethylvinylbenzine (CMVB) and vinylbenzine (VB) provided various compositions of the polymer. The preferred material, due to the relative ease of casting the film, and its relatively low hygroscopic nature, was a 2:1 ratio of CMVB to VB. Testing confirmed that at room temperature, the new membranes outperformed commercially available membranes by a large margin. With fuel cells now in use at NASA and in transportation, and with defense potential, any improvement to fuel cell efficiency is a significant development

LiGa(OTf)(sub 4) as an Electrolyte Salt for Li-Ion Cells

Lithium tetrakis(trifluoromethane sulfo - nato)gallate [abbreviated "LiGa(OTf)4" (wherein "OTf" signifies trifluoro - methanesulfonate)] has been found to be promising as an electrolyte salt for incorporation into both liquid and polymer electrolytes in both rechargeable and non-rechargeable lithium-ion electrochemical cells. This and other ingredients have been investigated in continuing research oriented toward im proving the performances of rechargeable lithium-ion electrochemical cells, especially at low temperatures. This research at earlier stages, and the underlying physical and chemical principles, were reported in numerous previous NASA Tech Briefs articles. As described in more detail in those articles, lithiumion cells most commonly contain nonaqueous electrolyte solutions consisting of lithium hexafluorophosphate (LiPF6) dissolved in mixtures of cyclic and linear alkyl carbonates, including ethylene carbonate (EC), propylene carbonate (PC), dimethyl carbonate (DMC), diethyl carbonate (DEC), and ethyl methyl carbonate (EMC). Although such LiPF6-based electrolyte solutions are generally highly ionically conductive and electrochemically stable, as needed for good cell performance, there is interest in identifying alternate lithium electrolyte salts that, relative to LiPF6, are more resilient at high temperature and are less expensive. Experiments have been performed on LiGa(OTf)4 as well as on several other candidate lithium salts in pursuit of this interest. As part of these experiments, LiGa(OTf)4 was synthesized by the reaction of Ga(OTf)3 with an equimolar portion of LiOTf in a solvent consisting of anhydrous acetonitrile. Evaporation of the solvent yielded LiGa(OTf)4 as a colorless crystalline solid. The LiGa(OTf)4 and the other salts were incorporated into solutions with PC and DMC. The resulting electrolyte solutions exhibited reasonably high ionic conductivities over a relatively wide temperature range down to 40 C (see figure). In cyclic voltammetry measurements, LiGa(OTf)4 and the other salts exhibited acceptably high electrochemical stability over the relatively wide potential window of 0 to 5 V versus Li+/Li. 13C nuclear-magneticresonance measurements yielded results that suggested that in comparison with the other candidate salts, LiGa(OTf)4 exhibits less ion pairing. Planned further development will include optimization of the salt and solvent contents of such electrolyte solutions and incorporation of LiGa(OTf)4 into gel and solid-state polymer electrolytes. Of the salts, LiGa(OTf)4 is expected to be especially desirable for incorporation into lithium polymer electrolytes, wherein decreased ion pairing is advantageous and the large delocalized anions can exert a plasticizing effect

Real-time Thermal Error Compensation Module for Intelligent Ultra Precision Turning Machine (iUPTM)

AbstractAccuracy & precision are 1he main requirements for ultra precision machine tools. Many factors affect 1he performance of 1he system 1hat in turns affect 1he product quality. Among all sources of errors, the thermo mechanical deformation errors are the main contributor for 1he overall geometrical errors. This paper mainly aims at establislunent of methodology to compensate thermal deformation errors in real-time for ultra precision machine tools. The real-time thermal error compensation module has been developed and integrated to intelligent Ultra Precision Turning machine. The module includes temperatures as inputs, neural network algorithm for computing the thermal deformations errors, ‘C’ programming for real-time calculations and integration with open architecture CNC controller. The module runs in silent mode which avoids human intervention for correction of thermal deformation errors

Effect of supplementing encapsulated microbial enzymes to corn-soybean meal based pelleted diets on performance and carcass variables in coloured broiler chicken

The experiment was conducted to determine the dietary supplementation of encapsulated (EC) or UEC enzymes on performance of colour broilers. The dietary supplementation of EC polysaccharide hydrolyzing enzymes and protease improved the performance compared to other groups. Feeding the birds with low nutrient-density diets did not affect the performance of the coloured broilers. The supplementation of EC enzymes resulted in a decrease in abdominal fat and increase in ready to cook yield compared to those diets with UEC or without enzymes

First Order Kaon Condensation in Neutron Stars: Finite Size Effects in the Mixed Phase

We study the role of Coulomb and surface effects on the phase transition from dense nuclear matter to a mixed phase of nuclear and kaon-condensed matter. We calculate corrections to the bulk calculation of the equation of state (EOS) and the critical density for the transition by solving explicitly for spherical, cylindrical, and planar structures. The importance of Debye screening in the determination of the charged particle profiles is studied in some detail. We find that the surface and Coulomb contributions to the energy density are small, but that they play an important role in the determination of the critical pressure for the transition, as well as affecting the size and geometry of favored structures. This changes the EOS over a wide range of pressure and consequently increases the maximum mass by about 0.1 solar masses. Implications for transport properties of the mixed phase are also discussed.Comment: 18 pages, 6 figure

Neutrino Opacities in Neutron Stars with Kaon Condensates

The neutrino mean free paths in hot neutron-star matter are obtained in the presence of kaon condensates. The kaon-induced neutrino absorption process, which is allowed only in the presence of kaon condensates, is considered for both nondegenerate and degenerate neutrinos. The neutrino mean free path due to this process is compared with that for the neutrino-nucleon scattering. While the mean free path for the kaon-induced neutrino absorption process is shown to be shorter than the ordinary two-nucleon absorption process by several orders of magnitude when temperature is not very high, the neutrino-nucleon scattering process has still a dominant contribution to the neutrino opacity. Thus, the kaon-induced neutrino absorption process has a minor effect on the thermal and dynamical evolution of protoneutron stars.Comment: 35 pages, 4 figure