A rare case of teenage adenoid cystic carcinoma of the breast

Adenoid cystic carcinoma (ACC) of the breast is very rare, accounting for only 0.1% of all breast carcinomas. Their rarity has made them difficult to study systematically with the most published series consisting of few cases or case reports; although, this existing evidence does suggest a good prognosis. ACC usually affects women, more in the sixth decade of life. However, our case has an exceptionally early onset of cancer at 16 years, the youngest ever reported in literature. Good local control can be obtained with lumpectomy and radiation or simple mastectomy for nearly all tumors. A routine axillary lymph node dissection is not recommended. We gave adjuvant radiotherapy to this patient in view of close margins and presence of lymphovascular emboli. She tolerated well with minimal side effects. Chemotherapy and hormonal therapy have no established benefit

Nanomedicine Clinical Use, Regulatory and Toxicology Issues in Europe

Nano medicine is a revolutionizing field that can benefit both diagnosis and treatment and contribute to a better quality of life. Despite the expected huge benefits, the potential risks on human health are significant as well. This thesis aims to defense a perspective that in case of nascent technologies, where the data are still emerging and scientific uncertainty prevails, risk governance should sustain the process of scientific knowledge by developing guidelines, codes of conduct and public information and provide a minimum level of safety acceptable to protect human health. Although Nano medicine is at an early stage of development some cautious measures should be taken that will provide regulatory mechanisms able to respond to the challenges posed by Nano medicine, establish a minimum level of safety but will also allow the further promotion of scientific knowledge. This multidisciplinary approach can contribute in adopting regulatory choices and tools that will help manage the risks, protect human health and promote scientific knowledge.  As the technologies are designed based on a clear understanding of a particular disease, disease specific oriented focus is required for the development of novel pharmaceuticals. In addition, it will be important to establish a case-by-case approach to clinical and regulatory evaluation of each Nano pharmaceutical. High priority should be given to enhancing communication and exchange of information among academia, industry and regulatory agencies encompassing all facets of this multidisciplinary approach. Keywords: novel pharmaceuticals, Nano pharmaceuticals, toxicological issues, clinical use, Nano medicine

Synthesis and Spectral Characterization of 1,2,4-triazole derivatives

The olefin moiety presents in styrylsulfonylmethyl-1,2,4-triazolylamine (1) was exploited to build up five-member heterocycle-pyrazoles. The series of novel pyrazolyl-1,2,4-triazole amine derivatives (2-3) have been synthesized. All the entitles compounds were characterized by 1H and 13C NMR spectra. © 2022 Author(s).The authors G. Sravya and N. Bakkthavatchala Reddy are thankful to Ural Federal University, Yekaterinburg, Russia for financial assistance and thankful to Prof. A. Padmaja for providing necessary lab facility to carry out this research work

SYNTHESIS AND SPECTRAL CHARACTERIZATION OF 1,2,4- TRIAZOLE DERIVATIVES

The azole derivatives are the prominent players in the pharmaceutical research as they possess several biological properties. In particular, triazoles represent a class of heterocyclic compounds with a wide variety of biological activities. Furthermore, heterocyclic compounds containing a 1,2,4-triazole nucleus have a broad spectrum of pharmacological activities, including anti-inflammatory, antimicrobial, anticancer, antiproliferative and apoptotic properties. Hence biological importance of heterocyclic compounds containing 1, 2, 4-triazole with their pharmacological potential has thereby made them extremely attractive research targets. Based on the above essential information, we have designed and synthesized different 1,2,4-triazole derivatives

KNOWLEDGE, ATTITUDE, AND PRACTICE TOWARD PHARMACOVIGILANCE AND ADVERSE DRUG REACTION REPORTING AMONG NURSING STAFF AND STUDENTS

 Objective: The objective of this study is to assess awareness of Pharmacovigilance among the healthcare professionals and to evaluate the impact of an educational intervention for improving awareness of Pharmacovigilance among the nursing staff and nursing students from Bengaluru, Karnataka, India.Methods: A cross-sectional study was carried out using a validated questionnaire that included demographic details and 20 survey items to evaluate the participants' knowledge, attitude, and perception (KAP) on adverse drug reactions (ADRs) and Pharmacovigilance. All participants received an interactive educational intervention in the form of a lecture. A pre- and post-KAP questionnaire survey was used to evaluate the impact of educational intervention among the participants. The Statistical Package for Social Sciences statistical software, version 16, was used to analyze the data.Results: A total of 103 healthcare professionals in the study responded to the pre- and post-KAP survey questionnaires. 66 nursing students and 37 nursing staff were involved in the study. The increased awareness among the study subjects about pharmacovigilance between pre- and post-intervention was statistically significant (p<0.001) which showed the effectiveness of educational intervention carried out.Conclusion: The results show that participants in the study were only moderately aware of ADR monitoring. However, they had expressed a positive attitude toward Pharmacovigilance and ADRs reporting. There is a need to create awareness among the nursing fraternity about ADR reporting for improving the spontaneous reporting

Not Available

Not AvailableNot AvailableNot Availabl

International journal of advanced scientific and technical research Issue 4 volume 2, A STUDY OF THE INFLUENCE OF PERSONALITY FACTORS ON THE REASONING OF MORAL JUDGMENT OF INTERMEDIATE STUDENTS

ABSTRACT The present educational system, with all its complexities has proved to be deficient in so far as it neglects or does not give the deserving importance to values in human ('F' -test) were employed for analysis of the data. Personality Factor -G has significant influence on the reasoning of moral judgment of intermediate students