Interaction of picolinic acid N-oxide and its derivatives with cobalt(II) involving some selected ligands in aqueous medium

792-794The formation constants of 1:1 binary chelates (ML of Co(II) with (L) picolinic acid N-oxide (Pico) and its derivatives 4-aminopicolinic acid N-oxide (4-NH2 Pico), 4-chloropicolinic acid N-oxide (4-Cl Pico) and 4-hydroxypicolinic acid N-oxide (4-OH Pico) and the corresponding 1:1:1 ternary chelates (MAL or MLA) involving (A) glycine, proline (N, O- donors); ethylenediamine, 1,10-phenanthroline (N,N donors); catechol, salicylic acid (O-,O- donors) and thioglycolic acid (S, O- donor) have been determined from pHmetric measurements at 30°C and 0.1 M (KNO3) ionic strength in aqueous medium. The stabilities of the binary chelates (ML) follow the order: 4-Cl Pico 2 Pica, while those of ternary complexes show a quite reverse trend. The relative stabilities of the ternary complexes are quantitatively expressed in terms of the statistical parameter, D log K. The results are discussed in the light of statistical and different astatistical factors. The thermodynmic parameters determined for the binary systems are found to be favourable for chelation

ANALYSIS OF GROUND WATER IN AND AROUND PYDIBHEEMAVARAM INDUSTRIAL AREA, SRIKAKULAM DIST, ANDHRA PRADESH, INDIA

ABSTRACT Over usage of ground water is influences quality of water. Present situation ground water quality is important factor at the time water shortage and human health in terms of water borne diseases. In the present study area, mainly focused on physic chemical parameters i.

ARE THE SIDE EFFECTS OF PARACETAMOL BOOSTED BY CAFFEINE??

Paracetamol (acetaminophen) with caffeine is a combination medicine indicated for the temporary relief of pain and discomfort associated with a number of conditions such as headache or muscle pain. Paracetamol has a narrow safety margin and there are number of risks associated with paracetamol. It is only safe and effective when used according to directions on OTC (Over- The-Counter) and Rx labelling. However, long-term use of paracetamol increases the risk of kidney and liver failure and makes people more vulnerable to high blood pressure and strokes.  Chronic or excessive administration of caffeine has been implicated in a range of dysfunctions involving the liver, renal system, gastrointestinal system, and musculature. A patient taking the combination of paracetamol with caffeine may be more likely to experience adverse effects than to get improved analgesia, compared with paracetamol alone. Keywords: Paracetamol, Caffeine, OTC, Hepatic ToxicityÂ

Assessment of ground water quality in an industrial agglomeration of Visakhapatnam, A. P

ABSTRACT Ground water is increasingly used for domestic, agricultural, industrial and other activities. Quality of water is the most important factor for any use; be it domestic or any other purposes. Indiscriminate use of ground water deteriorates the quality and quantity of water. The present work reports the physico-chemical characteristics of the ground waters collected from an industrialized urban agglomeration of Visakhapatnam city, Andhra Pradesh. The physicochemical parameters include pH, Turbidity, Conductivity, Total Dissolved Solids, Chlorides, Sulphates, Total Hardness, Calcium, Magnesium, Total Alkalinity, Nitrates and Fluorides. Though the data show that majority of the values are compatible with the maximum allowable standards recommended by BIS, still in depth studies are to be carried out to decide its suitability for safe drinking and domestic use. It is possible that the concentration of the dissolved impurities may increase further if the recommended norms for discharging industrial effluents are not adhered

Formation constants of binary and ternary complexes of Cu(II) with ninhydrin and some O,O; N, and N, N donor ligands in aqueous medium

385-386The formation constants of 1:1 and 1:2 binary chelates of Cu(II) with ninhydrin (1,2,3-triketohydrindene hydrate or 2,2-dihydroxy-1,3-indamedione) and the corresponding 1: 1: 1 ternary chelates involving oxalic acid, catechol, α-alanine, valine, ethylenediamine and 2,2-bipyridyl as primary Iigands have been determined pH metrically at 20°, 30°, 40°· and 50°C at 0.1 M (KNO3) ionic strength. The effect of change in ionic strength has also been studied at 30°C. The order of stabilities of, ternary complexes has been discussed in terms of ∆ log K, basicity of the Iigands, nature of donor sites and thermodynamic parameters

Highly efficient tandem syntheses of unsymmetrically substituted isomeric S,N-disubstituted-2-mercaptobenzimidazoles

829-832Highly efficient tandem syntheses of unsymmetrically substituted isomeric S,N-disubstituted-2-mercaptobenzimidazoles have been developed. The structures of 6a-d and isomeric compounds 9a-d have been synthesized from 2-mercaptobenzimi-dazole using tandem synthesis. The structures of 6a-d and isomeric compounds 9a-d have been established by spectral and analytical data, and by unambiguous syntheses

Green and efficient synthesis of 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydropthalazine-1,4-dione

412-4172-Hydrazinoquinazolin-3H-4-ones 1a,b were reacts with each of the anhydrides, phthalic anhydride 2a, succinic anhydride 2b and maleic anhydride 2c independently in PEG-600 at RT to yield 2-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazine-ecarbonyl)benzoic acid 3a,b, 4-oxo-4-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazinyl)butanoic acid 3c,d and 4-oxo-4-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazinyl)but-2-enoic acid 3e,f, respectively. 3a,b,<b style="mso-bidi-font-weight: normal"> 3c,d, 3e,f have been transformed into 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydrophthalazine-1,4-dione 4a,b, 1-(4-oxo-3,4-dihydroquinazolin-2-yl)piperazine-3,6-dione 4c,d and 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-1,2-dihydropyridazine-3,6-dione 4e,f, respectively by heating each in PEG-600 at 100 °C for 3-3.5 hr in high yields and in high purity, involving a dehydrative ring closure. The final compounds <b style="mso-bidi-font-weight: normal">4a-f have also been prepared alternatively by reacting 1 with <b style="mso-bidi-font-weight: normal">2 in PEG-600 at 100 °C for 3.5-4 hr

<span style="font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-US">Synthesis of N-alkylated-2-(1,3-diphenyl-1<i>H</i>-pyrazol-4-ylsulfanyl)-1<i>H</i>- benzimidazoles by Vilsmeir-Haack reaction and by condensation with DMF-DMA</span>

531-5372-(1H-Benzimidazol-2-ylsulfanyl)-1-phenylethanone 3 on condensation with phenyl hydrazine under acidic conditions gives the corresponding hydrazone derivative which when subjected to Vilsmeir Hack formylation followed by alkylation under phase transfer catalyst (PTC) conditions gives N-alkylated-2-(1,3-diphenyl-1H-pyrazol-4-ylsulfanyl)-1H-benzimidazole 7a-d. Alternatively 7a-d can also be prepared by treatment of 3 with DMF-DMA at RT for 3 hr giving 2-(1H-benzimidazol-2-ylsulfanyl)-3-dimethylamino-1-phenylpropenone 10 followed by condensation with phenyl hydrazine under acidic conditions and subsequent alkylation with an alkylating agent under PTC conditions. Compound <b style="mso-bidi-font-weight: normal">3 itself has been prepared from the well known benzimidazole thiol 1 by condensation with phenacyl bromide 2