Resolvable designs with large blocks

Resolvable designs with two blocks per replicate are studied from an optimality perspective. Because in practice the number of replicates is typically less than the number of treatments, arguments can be based on the dual of the information matrix and consequently given in terms of block concurrences. Equalizing block concurrences for given block sizes is often, but not always, the best strategy. Sufficient conditions are established for various strong optimalities and a detailed study of E-optimality is offered, including a characterization of the E-optimal class. Optimal designs are found to correspond to balanced arrays and an affine-like generalization.Comment: Published at http://dx.doi.org/10.1214/009053606000001253 in the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

Analysis of alcohol dependence phenotype in the COGA families using covariates to detect linkage

Linkage analysis methods that incorporate etiological heterogeneity of complex diseases are likely to demonstrate greater power than traditional linkage analysis methods. Several such methods use covariates to discriminate between linked and unlinked pedigrees with respect to a certain disease locus. Here we apply several such methods including two mixture models, ordered subset analysis, and a conditional logistic model to genome scan data on the DSM-IV alcohol dependence phenotype on the Collaborative Studies on Genetics of Alcoholism families, and compare the results to traditional nonparametric linkage analysis. In general, there was little agreement among the various covariate-based linkage statistics. Linkage signals with empirical p-values less than 0.001 were detected on chromosomes 3, 4, 7, 10, and 12, with the highest peak occurring at the GABRB1 gene using the ecb21 covariate

Compositional zoning of some metamorphic garnets from the Republic Trough, Upper Peninsula, Michigan

Thesis (B.A.)--University of Illinois at Urbana-Champaign, 1981.Bibliography: leaves [23-24].Microfiche of typescript. [Urbana, Ill.] : Photographic Services, University of Illinois, U of I Library, [1984]. 2 microfiches (43 frames) : negative ; 11 x 15 cm