5 research outputs found
Behavioral measurements of epilepsy following induction.
<p><b>A.</b> Distribution of weekly seizure frequency as observed during video monitoring (n = 10) <b>B.</b> Mean daily seizure frequency of animals during the recording period, data are expressed as mean ± SEM (n = 10). <b>C.</b> The percentage of animals meeting PSBB criteria at various weeks post-induction (n = 31). <b>D.</b> Touch x pickup and <b>E.</b> time bin pickup PSBB scores of animals having undergone <i>status</i> epilepticus induction (n = 37) and age-matched controls (criteria met/seizure observed, n = 13; criteria met/no seizure observed, n = 18; criteria not met/no seizure observed, n = 6; control, n = 12).</p
Spontaneous network activity in CA3 following establishment of SRS.
<p><b>A.</b> Raw data from CA3 recorded 90 days post-induction and in controls. Scale bar 200 ms x 50 μV. <b>B.</b> Power spectral density plots of the activity shown in A. <b>C.</b> Example Morlet-wavelet spectra and power spectral density plots of the same traces, white dotted lines on spectra indicate 20–60 Hz pseudo-frequency band. <b>C.</b> Pooled power and frequency plots for control and PSE 90d.</p
Spontaneous network activity in CA3 during the latent period.
<p><b>A.</b> Raw data from CA3 recorded during the latent period and in controls. Scale bar 200 ms x 50 μV. <b>B.</b> Power spectral density plots of the activity shown in A. <b>C.</b> Example Morlet-wavelet spectra and power spectral density plots of the same traces, white dotted lines on spectra indicate 20–60 Hz pseudo-frequency band. <b>C.</b> Pooled power and frequency plots for control and latent period.</p
Appearance of ictal-like events in CA3 and mEC in vitro.
<p><b>A.</b> Example ictal-like event recorded in CA3 in slices from a PSE 101 day animal with confirmed SRS. Trace length 50 s. Blue box denotes expanded timescale (scale bar 950 ms x 550 μV). <b>B.</b> Example Morlet-wavelet spectrum of the area delineated by the blue box in A. <b>C.</b> Example recording made in CA3, CA1, layers V and II of mEC during an ictal-like event generated in mEC (scale bar 950 ms x 500 μV), a section is shown at an expanded temporal scale for clarity.</p
Summary of <i>in vitro</i> network and behavioural observations at different stages of the RISE model.
<p>Summary of <i>in vitro</i> network and behavioural observations at different stages of the RISE model.</p