An A91V SNV-positive case (A-HE, staining, B-EBER-positive) showing negativity for p53 (C) and low-level of perforin expression (D).

<p>An A91V SNV-negative case (E-HE, staining, F-EBER-positive) showing intense expression of p53 (G) and perforin (H).</p

Most relevant immunohistochemical and clinical data of these series.

<p>NMF:No mutation found; M:Male; F:F; AD:Age at Diagnosis; LDD:Location of the disease at Diagnosis; N:Negative; P:Positive; NV: Not evaluable; HI: High-Intensity; LI:Low-Intensity; L:Low; Mo:Moderate; NP: Not present; NK: Not Known; PI:Perforin Intensity; PG: Perforin Granules; GR: Golgi Region; TC: Troughout the cytoplasm; A: Alive; D:Dead; OS: Overall Survival.</p

miRNAs differentially expressed between the two groups (MF <i>vs</i>. controls).

<p>miRNAs differentially expressed between the two groups (MF <i>vs</i>. controls).</p

Expression levels of miRNAs in the inflammatory skin and MF FFPE samples.

<p>The -∆Ct values indicate gain of expression. These miRNAs are increasingly expressed as the disease progresses (FFPE: formalin-fixed paraffin-embedded; MF: mycosis fungoides).</p

miRNAs differentially expressed between the two groups (early-stage MF vs. advanced-stage MF).

<p>miRNAs differentially expressed between the two groups (early-stage MF vs. advanced-stage MF).</p

MiRNA expression heatmap of 14 MF samples and 15 skin lesions.

<p>Significant miRNAs (p<0.05) are illustrated: downregulated in blue, upregulated in red (MF: mycosis fungoides; p: probability).</p

Comparison of the miRNA expression profiles of MF and inflammatory dermatitis samples identified 114 differentially dysregulated miRNAs.

<p>Comparison of the miRNA expression profiles of MF and inflammatory dermatitis samples identified 114 differentially dysregulated miRNAs.</p

Decrease in FOXP3 protein expression levels using western blot was found again in MYLA cell line after 48 h of transfection.

<p>Decrease in FOXP3 protein expression levels using western blot was found again in MYLA cell line after 48 h of transfection.</p

Expression levels of miRNA-146a and miRNA-181a in the MF FFPE paired samples.

<p>The -∆Ct values indicate gain of expression. These miRNAs are increasingly expressed as the disease progresses; miRNA-146a (p = 0.021) and miRNA-181a (p = 0.028). (FFPE: formalin-fixed paraffin-embedded; MF: mycosis fungoides; p: probability).</p

Expression levels of miRNA-26a, miRNA-222, miRNA-146a and miRNA-181a in MF FFPE samples.

<p>The -∆Ct values indicate gain of expression. These miRNAs are increasingly expressed as the disease progresses; miRNA-26a (p = 0.034), miRNA-222 (p = 0.042), miRNA-146a (p = 0.051) and miRNA-181a (p = 0.056) (FFPE: formalin-fixed paraffin-embedded; MF: mycosis fungoides).</p