21 research outputs found

    Pandemic as Opportunity

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    The COVID-19 pandemic presented the Kennesaw State University Library System with the question, " How can the library maintain live face-to-face reference services in a manner that is safe for all involved ?" Challenges to creating a live virtual reference desk that arose included the need to serve two campuses simultaneously, librarians working from home, and using conferencing technology in unexplored ways. The resulting Virtual In-Person (VIP) Reference service was the answer to our immediate situation, yet lessons were learned for future opportunities to push our services beyond the traditional

    Pandemic as Opportunity: Creating and Implementing a Live Virtual Reference Desk

    No full text
    The COVID-19 pandemic presented the Kennesaw State University Library System with the question, How can the library maintain live face-to-face reference services in a manner that is safe for all involved ? Challenges to creating a live virtual reference desk that arose included the need to serve two campuses simultaneously, librarians working from home, and using conferencing technology in unexplored ways. The resulting Virtual In-Person (VIP) Reference service was the answer to our immediate situation, yet lessons were learned for future opportunities to push our services beyond the traditional

    Role of the polarity protein, Scribble, in Hematopoiesis and Leukemia

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    The polarity protein, Scribble, is a member of a group of proteins responsible for the apical basal polarity in epithelia. Scribble is highly conserved from flies to humans and is deregulated in a number of human epithelial cancers including cervical, colon, breast and prostate but its role in blood cancers has not been explored. As Scribble knockout mice are embryonic lethal, dying from a severe neural tube closure defect, we have developed conditional knockout mice using the Mx1-Cre model to explore the role of Scribble in hematopoiesis in both steady state and leukemia. Expression of Scribble in hematopoietic organs and specific lineages was confirmed using multiple approaches. We established that loss of PTEN results in myeloproliferative disease with progression to T-ALL or AML/T-ALL. Pten/Scribble double knockouts have similar symptoms of disease as Pten single knockouts: splenomegaly, hepatomegaly, enlarged lymph nodes and thymus, terminal deoxynucleotidyl transferase (Tdt)-positive cells in the thymus and/or an abundance of blasts in the spleen. Both Pten single knockouts and Pten/Scribble double knockouts have a block in the Pre-Pro B stage of B cell development in the bone marrow and in the DN1 stage of T cell differentiation in the thymus. Preliminary examination of disease burden between Pten single knockouts and Pten/Scribble double knockouts suggests a shift from T-ALL to AML in Pten/Scribble double knockouts. We are currently investigating this and other differences between double and single knockout mice and the underlying mechanisms for these differences with the ultimate aim of generating novel chemotherapeutic targets for treatment of T-ALL and AM
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