9 research outputs found
Exile Vol. XXXVII No. 1
And It Was Sunday by Julie Gruen 1-6
Like a Lady by Grace Mulvihill 7
The Final You by Eric Franzon 8
Joseph\u27s Children by Seneca Murley 9
Ain\u27t the 1950s Anymore by Ellen Stader 10-12
Bonding Women by Shannon salser 13
Ice Man (for mami 1905-1975) by Anne Mulligan 14
The Car Salesman by Tom Ream 15
Cancelling the Bunny by Stewart Engesser 16-17
Richard Brautigan\u27s Body by Michael Payne 18-19
Dinner in Barcelona by Holly Kurtz 20
Untitled by Margaret Strachen 21
Candles by Eric Franzon 22
Summer Rules by Jim Cox 23-31
My Boat by Holly Kurtz 32
Untitled by Michael Payne 33
Half the Birds in the City by Tiffany Richardson 34-35
Down Queen Anne Hill by Julie Gruen 36-37
Your Music by Tim Emrick 38
Zephyrs by Steve Corinth 39-41
Mother by Anne Mulligan 42
As I Look to the Sky, Maize by Shannon Salser 43-45
Close Book before Striking by Sarah Verdon 46-47
Smoked by Tom Ream 48
Driving through Rain by Stewart Engesser 49-50
Contributors 51
Editorial decision is shared equally among the Editorial Board. -i
35th Yea
Exile Vol. XXXVII No. 2
Once and for All by Michael Payne 1
Alone Over The Trees by John Stoddard 2
Caught You by Nancy Booth 3
Mother\u27s Words by Julie Green 4-10
His Token by Donna Marie Voldness 11-12
Global Warming by Eric Franzon 13-14
Amish Mystery by Shannon Salser 15
For Peace by Robin Schneider 16-18
Elvis, the Lizard King, and Me by Stewart Engesser 19-22
Norpell Woods by Brandon Pfeiffer 23
Blue Suit, Red Dog by Jack Beck 24
I Am Without My List of Excusses [sic] by Douglas George 25
Somtimes - Satre Would Not Be Proud by Dana Wells 26
The Flock by Carter Holland 27-33
Dance of Alabaster by Jay Speiden 34
Winter Solstice by K. Lynn Rogers 35-36
Fish Story by Jim Dixon 37-42
Slumming by Stewart Engesser 43
Beached by Chris Dealy 44
The Missing Man by Tom Ream 45-47
Elegy by Scott Dexter 48
Close Range by Jay Speiden 49
No Longer by Shannon Salser 50
In A Bar In Georgetown, Colorado 1990 by John Stoddard 51
untitled by Brian Wills 52
Editorial decision is shared equally among the Editorial Board. -i
Cover: Megan Doyle -i
NOTE: I Am Without My List of Excusses [sic] by Douglas George 25 is listed as I Am Without My List of Excuses on page 25. The published table of contents is followed here
Extreme weather events influence dispersal of naive northern fur seals
Since 1975, northern fur seal (Callorhinus ursinus) numbers at the Pribilof Islands (PI) in the Bering Sea have declined rapidly for unknown reasons. Migratory dispersal and habitat choice may affect first-year survivorship, thereby contributing to this decline. We compared migratory behaviour of 166 naive pups during 2 years from islands with disparate population trends (increasing: Bogoslof and San Miguel Islands; declining: PI), hypothesizing that climatic conditions at weaning may differentially affect dispersal and survival. Atmospheric conditions (Bering Sea) in autumn 2005–2006 were anomalously cold, while 2006–2007 was considerably warmer and less stormy. In 2005, pups departed earlier at all sites, and the majority of PI pups (68–85%) departed within 1 day of Arctic storms and dispersed quickly, travelling southwards through the Aleutian Islands. Tailwinds enabled faster rates of travel than headwinds, a trend not previously shown for marine mammals. Weather effects were less pronounced at Bogoslof Island (approx. 400 km further south), and, at San Miguel Island, (California) departures were more gradual, and only influenced by wind and air pressure in 2005. We suggest that increasingly variable climatic conditions at weaning, particularly timing, frequency and intensity of autumnal storms in the Bering Sea, may alter timing, direction of dispersal and potentially survival of pups
Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening
Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9) as a potential therapeutic target of chemoresistant disease. A2780cis (cisplatin-resistant) and A2780 (cisplatin-sensitive) ovarian carcinoma cell lines were used. The cytotoxic effect of MMP-9/MMP-2 inhibitor, (2R)-2-[(4-Biphenylsulfonyl) amino]-3 phenylpropionic acid (C21H19NO4S) alone or in combination with cisplatin was determined using high content screening. Protein expression was examined using immunohistochemistry and ELISA. Co-incubation of cisplatin and an MMP-9/MMP-2 inhibitor, (2R)-2-[(4-Biphenylsulfonyl) amino]-3 phenylpropionic acid (C21H19NO4S) resulted in significantly greater cytotoxicity as compared to either treatment alone in a cisplatin resistant MMP-9 overexpressing cell line; A2780cis. In addition, pre-incubating with MMP-9i prior to cisplatin further enhances the cytotoxic effect. No significant difference was observed in MMP-9 protein in tissue but a trend towards increased MMP-9 was observed in recurrent serum. We propose that MMP-9/MMP-2i may be utilized in the treatment of recurrent/chemoresistant ovarian cancers that overexpress MMP-9 mRNA but its role in vivo remains to be evaluated