Smart and networking underwater robots in cooperation meshes : the swarms ECSEL : H2020 project

The work presented on this paper is aimed to explain the role that unmanned underwater vehicles (AUVs/ROVs) plays in the ECSEL-H2020 SWARMS project. The main goal of the project is to reduce the operational cost and increase the safety of tasks assigned to divers in these operations. This will be achieved enabling the AUVs/ROVs to work in a cooperative mesh. The challenge is to design and develop an integrated platform (a set of Software/Hardware components), incorporated into the current generation of underwater vehicles in order to improve autonomy, cooperation, robustness, cost-effectiveness, and reliability of the offshore operations. The first demonstration of the project will be performed at PLOCAN (Oceanic Platform of the Canary Islands) where these technologies will be validated on its first stage.Peer Reviewe

Cold-formed stainless steel CHS beam-columns – testing, simulation and design

The present work was prompted by shortcomings identi ed in existing design provisions for stainless steel circular hollow section (CHS) beam-columns. First, addressing a lack of existing experimental data, a series of ferritic stainless steel CHS beam-column tests was undertaken at the cross-section and member levels. In total, 26 beam-column tests, including two section sizes (a non-slender class 3 and slender class 4 cross-section), two member slenderness values for each cross-section type and a wide range of loading eccentricities were carried out to investigate the interaction between local and global buckling. Following validation of nite element (FE) models, a numerical study was then undertaken to explore the buckling response of stainless steel CHS beam-columns, covering austenitic, duplex and ferritic grades with a wide range of local and global slendernesses and applied loading eccentricities. Over 2000 numerical results were generated and used to assess new design proposals for stainless steel beam-columns, featuring improved compression and bending end points and new interaction factors. The new proposals are more consistent and more accurate in their resistance predictions than the current EN 1993-1-4 (2015) design approach. The reliability of the new proposals has been veri ed by means of statistical analyses according to EN 1990 (2005)

Risk factors for human papillomavirus infection among women in Portugal: the CLEOPATRE Portugal Study

OBJECTIVE: To investigate demographic, socioeconomic, lifestyle, and medical factors that might predispose women to cervical human papillomavirus (HPV) infection. METHOD: A cross-sectional population-based study was performed. Women aged 18-64 years who attended selected obstetrics and gynecology or sexually transmitted disease (STD) clinics in mainland Portugal between February 2008 and March 2009 were recruited, according to an age-stratified sampling strategy. Liquid-based cytology samples were analyzed centrally for HPV genotype and for cytologic features. Univariate and multivariate logistic regression analyses identified risk factors for HPV infection. RESULTS: Among the 2326 women evaluated, the crude prevalence of HPV infection was 19.4%. Lifetime number of sexual partners was a strong predictor of HPV infection (odds ratio 5.44 for 5-10 partners versus 1 partner; P<0.001). Other risk factors were young age (particularly among women aged 20-24 years; P<0.001); country of birth other than mainland Portugal (P=0.002); education up to secondary school level (P=0.010); smoking history (≤ 10 years; P=0.004); and any STD in the past 12 months (P=0.052). CONCLUSION: Data from the present study may aid identification of women at increased risk of HPV infection and target prevention strategies. TRIAL REGISTRATION: National Commission of Data Protection (CNPD) registration number 5346/2007; Sanofi Pasteur MSD study number HPV-E05.info:eu-repo/semantics/publishedVersio

Comparison of Nasopharyngeal Samples for SARS‐CoV ‐2 Detection in a Paediatric Cohort

Aim: The diagnosis of coronavirus disease 2019 (COVID-19) depends on accurate and rapid testing. Choosing an appropriate sample may impact diagnosis. Naso-oropharyngeal swabs (NOS) are most frequently used, despite several limitations. Since studies suggest nasopharyngeal aspirate (NPA) as a superior alternative in children, we hypothesised collecting both nasopharyngeal swab and aspirate would improve our diagnostic accuracy. Methods: Observational, longitudinal, prospective study from 7 March to 7 May in a tertiary paediatric hospital in Lisbon. The objective was to compare the rate of detection of SARS-CoV-2 between NOS and NPA samples collected simultaneously. Results: A total of 438 samples collected from 85 patients with confirmed COVID-19. There were 47.7% overall positive specimens - 32% (70/219) positive NOS and 63.5% (139/219) positive NPA. The tests were 67.6% concordant (k = 0.45). 50.3% had positive NPA with negative NOS, while 1.3% had positive NOS with negative NPA. NPA proved to be more sensitive (98.6% with 95% confidence interval 91.2-99.9% vs. 49.6% with 95% confidence interval 41.1-58.2%, P < 0.001). Additionally, the difference between NPA and NOS positive samples was statistically significant across all population groups (age, health condition, clinical presentation, contact with COVID-19 patients or need for hospitalisation), meaning NPA is more sensitive overall. Conclusions: Nasopharyngeal aspirates had greater sensitivity than naso-oropharyngeal swabs in detecting SARS-CoV-2. Our results suggest paediatric patients would benefit from collecting nasopharyngeal aspirates in hospital settings, whenever feasible, to improve diagnosis of COVID-19.info:eu-repo/semantics/publishedVersio

Risk factors for human papilomavirus infection among women in Portugal: the CLEOPATRE Portugal Study

OBJECTIVE: Human papillomavirus (HPV) is responsible for a range of diseases, including cervical cancer. The primary objectives of the CLEOPATRE Portugal study were to estimate the overall and age-stratified prevalence of cervical HPV infection and to assess HPV prevalence and type-specific distribution by cytological results among women aged 18 to 64 years, who reside in mainland Portugal. MATERIALS AND METHODS: This cross-sectional population-based study recruited women aged 18 to 64 years, according to an age-stratified sampling strategy, who attended gynecology/obstetrics or sexually transmitted disease clinics across the 5 regional health administrations in mainland Portugal between 2008 and 2009. Liquid-based cytology samples were collected and analyzed centrally for HPV genotyping (clinical array HPV 2 assay) and cytology. Prevalence estimates were adjusted for age using 2007 Portuguese census data. RESULTS: A total of 2326 women were included in the study. The overall prevalence of HPV infection in the study was 19.4% (95% confidence interval, 17.8%-21.0%), with the highest prevalence in women aged 18 to 24 years. High-risk HPV types were detected in 76.5% of infections, of which 36.6% involved multiple types. The commonest high-risk type was HPV-16. At least 1 of the HPV types 6/11/16/18 was detected in 32.6% of infections. The HPV prevalence in normal cytology samples was 16.5%. There was a statistically significant association between high-risk infection and cytological abnormalities (P < 0.001). CONCLUSIONS: This is the first population-based study to quantify and describe cervical HPV infection in mainland Portugal. This study provides baseline data for future assessment of the impact of HPV vaccination programs

Trigger and readout electronics for the STEREO experiment

The STEREO experiment will search for a sterile neutrino by measuring the anti-neutrino energy spectrum as a function of the distance from the source, the ILL nuclear reactor. A dedicated electronic system, hosted in a single microTCA crate, was designed for this experiment. It performs triggering in two stages with various selectable conditions, processing and readout via UDP/IPBUS of 68 photomultiplier signals continuously digitized at 250 MSPS. Additionally, for detector performance monitoring, the electronics allow on-line calibration by driving LED synchronously with the data acquisition. This paper describes the electronics requirements, architecture and the performances achieved.Comment: Topical Workshop on Electronics for Particle Physics (TWEPP) 2015, Lisboa. 9 pages, 9 figure

A novel role for proline- and acid-rich basic region leucine zipper (PAR bZIP) proteins in the transcriptional regulation of a BH3-only proapoptotic gene.

Proline- and acid-rich (PAR) basic region leucine zipper (bZIP) proteins thyrotroph embryonic factor (TEF), D-site-binding protein (DBP), and hepatic leukemia factor have been involved in neurotransmitter homeostasis and amino acid metabolism. Here we demonstrate a novel role for these proteins in the transcriptional control of a BH3-only gene. PAR bZIP proteins are able to transactivate the promoter of bcl-gS. This promoter is particularly responsive to TEF activation and is silenced by NFIL3, a repressor that shares the consensus binding site with PAR bZIP proteins. Consistently, transfection of TEF induces the expression of endogenous bcl-gS in cancer cells, and this induction is independent of p53. A naturally occurring variant of DBP (tDBP), lacking the transactivation domain, has been identified and shown to impede the formation of active TEF dimers in a competitive manner and to reduce the TEF-dependent induction of bcl-gS. Of note, treatment of cancer cells with etoposide induces TEF activation and promotes the expression of bcl-gS. Furthermore, blockade of bcl-gS or TEF expression by a small interfering RNA strategy or transfection with tDBP significantly reduces the etoposide-mediated apoptotic cell death. These findings represent the first described role for PAR bZIP proteins in the regulation of a gene involved in the execution of apoptosis