Drug Addiction and Personal Responsibility

This project examines drug addiction and personal responsibility from the perspective of three different types of theories of addiction: full responsibility, diminished responsibility, and no responsibility. The rational theory of addiction is the fully responsibility theory. The philosophical insights by R. Jay Wallace and George Graham are the diminished responsibility theories. Berridge and Robinson’s Incentive Salience theory of drug addiction is the no responsibility theory examined. My conclusion is that diminished responsibility frameworks are the most suitable in a therapeutic context because they are most sensitive to relevant normative aspects

Towards a science of human stories: using sentiment analysis and emotional arcs to understand the building blocks of complex social systems

We can leverage data and complex systems science to better understand society and human nature on a population scale through language --- utilizing tools that include sentiment analysis, machine learning, and data visualization. Data-driven science and the sociotechnical systems that we use every day are enabling a transformation from hypothesis-driven, reductionist methodology to complex systems sciences. Namely, the emergence and global adoption of social media has rendered possible the real-time estimation of population-scale sentiment, with profound implications for our understanding of human behavior. Advances in computing power, natural language processing, and digitization of text now make it possible to study a culture\u27s evolution through its texts using a big data lens. Given the growing assortment of sentiment measuring instruments, it is imperative to understand which aspects of sentiment dictionaries contribute to both their classification accuracy and their ability to provide richer understanding of texts. Here, we perform detailed, quantitative tests and qualitative assessments of 6 dictionary-based methods applied to 4 different corpora, and briefly examine a further 20 methods. We show that while inappropriate for sentences, dictionary-based methods are generally robust in their classification accuracy for longer texts. Most importantly they can aid understanding of texts with reliable and meaningful word shift graphs if (1) the dictionary covers a sufficiently large enough portion of a given text\u27s lexicon when weighted by word usage frequency; and (2) words are scored on a continuous scale. Our ability to communicate relies in part upon a shared emotional experience, with stories often following distinct emotional trajectories, forming patterns that are meaningful to us. By classifying the emotional arcs for a filtered subset of 4,803 stories from Project Gutenberg\u27s fiction collection, we find a set of six core trajectories which form the building blocks of complex narratives. We strengthen our findings by separately applying optimization, linear decomposition, supervised learning, and unsupervised learning. For each of these six core emotional arcs, we examine the closest characteristic stories in publication today and find that particular emotional arcs enjoy greater success, as measured by downloads. Within stories lie the core values of social behavior, rich with both strategies and proper protocol, which we can begin to study more broadly and systematically as a true reflection of culture. Of profound scientific interest will be the degree to which we can eventually understand the full landscape of human stories, and data driven approaches will play a crucial role. Finally, we utilize web-scale data from Twitter to study the limits of what social data can tell us about public health, mental illness, discourse around the protest movement of #BlackLivesMatter, discourse around climate change, and hidden networks. We conclude with a review of published works in complex systems that separately analyze charitable donations, the happiness of words in 10 languages, 100 years of daily temperature data across the United States, and Australian Rules Football games

A Case of Recurrent Breast Cancer Diagnosed from Symptomatic Metastasis to Bladder

Abstract: Women in the United States have an approximate 1 in 8 chance of developing breast cancer in their lifetime. The main cause of death from breast cancer is from metastatic spread of the disease; with the most frequent sites of spread being to the bone, brain, and lungs. The urinary bladder is a rare site of metastasis that has been rarely reported on in the literature. Here we present a case of recurrent metastatic breast cancer found in the urinary bladder without findings of any other sites of metastasis

Tracking climate change through the spatiotemporal dynamics of the Teletherms, the statistically hottest and coldest days of the year

Instabilities and long term shifts in seasons, whether induced by natural drivers or human activities, pose great disruptive threats to ecological, agricultural, and social systems. Here, we propose, measure, and explore two fundamental markers of location-sensitive seasonal variations: the Summer and Winter Teletherms - the on-average annual dates of the hottest and coldest days of the year. We analyse daily temperature extremes recorded at 1218 stations across the contiguous United States from 1853-2012, and observe large regional variation with the Summer Teletherm falling up to 90 days after the Summer Solstice, and 50 days for the Winter Teletherm after the Winter Solstice. We show that Teletherm temporal dynamics are substantive with clear and in some cases dramatic shifts reflective of system bifurcations. We also compare recorded daily temperature extremes with output from two regional climate models finding considerable though relatively unbiased error. Our work demonstrates that Teletherms are an intuitive, powerful, and statistically sound measure of local climate change, and that they pose detailed, stringent challenges for future theoretical and computational models

Predicting flow reversals in a computational fluid dynamics simulated thermosyphon using data assimilation

A thermal convection loop is a annular chamber filled with water, heated on the bottom half and cooled on the top half. With sufficiently large forcing of heat, the direction of fluid flow in the loop oscillates chaotically, dynamics analogous to the Earth\u27s weather. As is the case for state-of-the-art weather models, we only observe the statistics over a small region of state space, making prediction difficult. To overcome this challenge, data assimilation (DA) methods, and specifically ensemble methods, use the computational model itself to estimate the uncertainty of the model to optimally combine these observations into an initial condition for predicting the future state. Here, we build and verify four distinct DA methods, and then, we perform a twin model experiment with the computational fluid dynamics simulation of the loop using the Ensemble Transform Kalman Filter (ETKF) to assimilate observations and predict flow reversals. We show that using adaptively shaped localized covariance outperforms static localized covariance with the ETKF, and allows for the use of less observations in predicting flow reversals. We also show that a Dynamic Mode Decomposition (DMD) of the temperature and velocity fields recovers the low dimensional system underlying reversals, finding specific modes which together are predictive of reversal direction

Divergent discourse between protests and counter-protests: #BlackLivesMatter and #AllLivesMatter

Since the shooting of Black teenager Michael Brown by White police officer Darren Wilson in Ferguson, Missouri, the protest hashtag #BlackLivesMatter has amplified critiques of extrajudicial killings of Black Americans. In response to #BlackLivesMatter, other Twitter users have adopted #AllLivesMatter, a counter-protest hashtag whose content argues that equal attention should be given to all lives regardless of race. Through a multi-level analysis of over 860,000 tweets, we study how these protests and counter-protests diverge by quantifying aspects of their discourse. We find that #AllLivesMatter facilitates opposition between #BlackLivesMatter and hashtags such as #PoliceLivesMatter and #BlueLivesMatter in such a way that historically echoes the tension between Black protesters and law enforcement. In addition, we show that a significant portion of #AllLivesMatter use stems from hijacking by #BlackLivesMatter advocates. Beyond simply injecting #AllLivesMatter with #BlackLivesMatter content, these hijackers use the hashtag to directly confront the counter-protest notion of “All lives matter.” Our findings suggest that Black Lives Matter movement was able to grow, exhibit diverse conversations, and avoid derailment on social media by making discussion of counter-protest opinions a central topic of #AllLivesMatter, rather than the movement itself