Pantothenate kinase-associated neurodegeneration: Clinical aspects, diangnosis and treatments

Pantothenate Kinase-Associated, Neurodegeneration (PKAN) is an autosomal, recessive disorder characterized by a, mutation in the PANK2 gene. The clinical, presentation may range from only speech, disorder to severe generalized dystonia, spasticity, Visual loss, dysphagia and, dementia. The hallmark of this disease is, eyes of the tiger signs in the medial aspect, of bilateral globus pallidus on T2-weighted, MRI that is a hyperintense lesion surrounded, by hypointensity. Common treatments, for PKAN disease include anticholinergics, botulinum toxin, Oral and Intrathecal, baclofen, Iron chelation drugs and surgical, procedures such as ablative pallidotomy or, thalamotomy, Deep brain stimulation., There are many controversies about the, pathogenesis and treatment of this disease, and in recent years interesting studies have, been done on PKAN disease and other similar, diseases. This review summarizes the, clinical presentation, etiology, imaging, modalities and treatment. © S. Razmeh et al

Pantothenate kinase-associated neurodegeneration: Clinical aspects, diangnosis and treatments

Pantothenate Kinase-Associated, Neurodegeneration (PKAN) is an autosomal, recessive disorder characterized by a, mutation in the PANK2 gene. The clinical, presentation may range from only speech, disorder to severe generalized dystonia, spasticity, Visual loss, dysphagia and, dementia. The hallmark of this disease is, eyes of the tiger signs in the medial aspect, of bilateral globus pallidus on T2-weighted, MRI that is a hyperintense lesion surrounded, by hypointensity. Common treatments, for PKAN disease include anticholinergics, botulinum toxin, Oral and Intrathecal, baclofen, Iron chelation drugs and surgical, procedures such as ablative pallidotomy or, thalamotomy, Deep brain stimulation., There are many controversies about the, pathogenesis and treatment of this disease, and in recent years interesting studies have, been done on PKAN disease and other similar, diseases. This review summarizes the, clinical presentation, etiology, imaging, modalities and treatment. © S. Razmeh et al

Does intravenous administration of recombinant tissue plasminogen activator for ischemic stroke can cause inferior myocardial infarction?

Recombinant tissue plasminogen activator (rTPA) is one of the main portions of acute ischemic stroke management, but unfortunately has some complications. Myocardial infarction (MI) is a hazardous complication of administration of intravenous rTPA that has been reported recently. A 78-year-old lady was admitted for elective coronary artery bypass graft surgery. On the second day of admission, she developed acute left hemiparesis and intravenous rTPA was administered within 120 minutes. Three hours later, she has had chest pain. Rescue percutaneous coronary intervention was performed on right coronary artery due to diagnosis of inferior MI, and the symptoms were resolved. © M. Almasi et al. 2016 Licensee PAGEPress, Italy

Atherosclerosis in patients with endometriosis

Endometriosis refers to endometrial tissue implantation including stromal and epithelial tissue outside the uterus. It is an often painful disorder that involves the ovaries and fallopian tubes. The association between endometriosis and atherosclerosis is interesting. The present study was conducted to assess the Doppler findings of the carotid artery in patients with and without endometriosis. In this study that included 30 patients with endometriosis and 30 control subjects, all patients underwent carotid ultrasonography, and the measurement of intima-media thickness (IMT) was done in the distal common carotid artery, proximal to the origin of the carotid bulb, and finally, we compare the IMT in two groups. This study revealed that there are no differences in the IMT between patients with and without Endometriosis. © Copyright A.H. Habibi, et al., 2019

A novel homozygous variation in the PANK2 gene in two Persian siblings with atypical pantothenate kinase associated neurodegeneration

Pantothenate Kinase-associated Neurodegeneration (PKAN) is an autosomal recessive disorder that is caused by variation in pantothenate kinase-2 gene (PANK2) gene on chromosome 20. The common presentation of this disease includes progressive dystonia, Parkinsonism, retinopathy, cognitive impairment, and spasticity. The typical magnetic resonance imaging finding is eye of the tiger sign in globus pallidus and not pathogenic and not found in all patients. In the present study, we describe two siblings who have a novel variation of the PANK2 gene. These patients with the same genotype, have different ages at the onset of disease and also the various severity of the disease. The description of these cases helps to understand this disease, its symptoms, pathogenesis, and its treatment. © A.H. Habibi et al., 2019

The Effects of Intrahippocampus Injection of Almond oil on Passive Avoidance Learning and Memory in Adult Male Rat

Abstract Background & aim: Almond oil contains compounds such asoleic acid, omega 3, 6, 9 polyunsaturated fatty acids and vitamin E. The aim of this study was to investigate the effects of intra-hippocampal injection of almond oil on passive avoidance learning and memory in male rats. Methods: In this experimental study, 56 male rats were randomly divided into 8 groups, including a control, 3 sailin groups which received normal saline 0.5, 1, 2 µl and 4 peanut oil groups which received 5/0, 1, 5/1 and 2 µl of oil.All groups, except the control, Groups except the control group were cannulated with stereotaxic surgery in the left CA1 region. One week after recovery, all groups were trained by shuttle box. Immediately after training, different doses of almond oil and saline were injected through the cannula in CA1 of hippocampus. After 48 hours, their Passive avoidance memory and learning were evaluated. Data were analyzed by ANOVA. Results: Almond oil doses of 0.5,1, 1.5 and 2 µg significantly improved passive avoidance learning and memory (P<0.05), but saline did not have. Conclusion: Almond oil as a steroid, effects on learning and memory and can improve learning and memory. Key Words: Learning, Memory, Almond oil, Hippocampus and Shuttle Bo