Oncogenic Potential of Hepatitis C Virus Proteins

Chronic hepatitis C virus (HCV) infection is a major risk factor for liver disease progression, and may lead to cirrhosis and hepatocellular carcinoma (HCC). The HCV genome contains a single-stranded positive sense RNA with a cytoplasmic lifecycle. HCV proteins interact with many host-cell factors and are involved in a wide range of activities, including cell cycle regulation, transcriptional regulation, cell proliferation, apoptosis, lipid metabolism, and cell growth promotion. Increasing experimental evidences suggest that HCV contributes to HCC by modulating pathways that may promote malignant transformation of hepatocytes. At least four of the 10 HCV gene products, namely core, NS3, NS5A and NS5B play roles in several potentially oncogenic pathways. Induction of both endoplasmic reticulum (ER) stress and oxidative stress by HCV proteins may also contribute to hepatocyte growth promotion. The current review identifies important functions of the viral proteins connecting HCV infections and potential for development of HCC. However, most of the putative transforming potentials of the HCV proteins have been defined in artificial cellular systems, and need to be established relevant to infection and disease models. The new insight into the mechanisms for HCV mediated disease progression may offer novel therapeutic targets for one of the most devastating human malignancies in the world today

Rate enhancement of gated drift-diffusion process by optimal resetting

`Gating' is a widely observed phenomenon in biochemistry that describes the transition between the activated (or open) and deactivated (or closed) states of an ion-channel, which makes transport through that channel highly selective. In general, gating is a mechanism that imposes an additional restriction on a transport, as the process ends only when the `gate' is open and continues otherwise. When diffusion occurs in presence of a constant bias to a {\it gated} target, i.e., to a target that switches between an open and a closed state, the dynamics essentially slows down compared to {\it ungated} drift-diffusion, resulting in an increase in the mean completion time. In this work, we utilize stochastic resetting as an external protocol to counterbalance the delay due to gating. We consider a particle that undergoes drift-diffusion in the presence of a stochastically gated target and is moreover subjected to a rate-limiting resetting dynamics. Calculating the minimal mean completion time rendered by an optimal resetting for this exactly-solvable system, we construct a phase diagram that owns three distinct phases: (i) where resetting can make gated drift-diffusion faster even compared to the original ungated process, (ii) where resetting still expedites gated drift-diffusion, but not beyond the original ungated process, and (iii) where resetting fails to expedite gated drift-diffusion. Gated drift-diffusion aptly models various stochastic processes such as chemical reactions that exclusively take place for certain activated state of the reactants. Our work predicts the conditions where stochastic resetting can act as a useful strategy to enhance the rate of such processes without compromising on their selectivity.Comment: 12 Pages, 8 Figure

On Isometric Embeddability of SqmS_q^m into SpnS_p^n as non-commutative Quasi-Banach spaces

The existence of isometric embedding of $S_q^m$ into $S_p^n$, where $1\leq p\neq q\leq \infty$ and $m,n\geq 2$ has been recently studied in \cite{JFA22}. In this article, we extend the study of isometric embeddability beyond the above mentioned range of $p$ and $q$. More precisely, we show that there is no isometric embedding of the commutative quasi-Banach space $\ell_q^m(\R)$ into $\ell_p^n(\R)$, where $(q,p)\in (0,\infty)\times (0,1)$ and $p\neq q$. As non-commutative quasi-Banach spaces, we show that there is no isometric embedding of $S_q^m$ into $S_p^n$, where $(q,p)\in (0,2)\times (0,1)$ $\cup\, \{1\}\times (0,1)\setminus \{\frac{1}{n}:n\in\mathbb{N}\}$ $\cup\, \{\infty\}\times (0,1)\setminus \{\frac{1}{n}:n\in\mathbb{N}\}$ and $p\neq q$. Moreover, in some restrictive cases, we also show that there is no isometric embedding of $S_q^m$ into $S_p^n$, where $(q,p)\in [2, \infty)\times (0,1)$. To achieve our goal we significantly use Kato-Rellich theorem and multiple operator integrals in perturbation theory, followed by intricate computations involving power-series analysis.Comment: 18 page

Impact of Real-time Assessment on the Training of Trainers for the Introduction of Rotavirus Vaccine in India

Background and aim: The introduction of rotavirus vaccine (RVV) in the universal immunization program of India is a big feat as it became the first nation in the World Health Organization (WHO) Southeast Asia region to do so. The involvement of huge numbers of frontline workers in introducing new vaccines in India and the underlined deficits in skills and knowledge require efficient capacity building programs. In view of this, limited research is available on the effectiveness of capacitybuilding interventions for healthcare workers. There is a dearth of studies from India measuring the “on-spot” impact of immunization trainings on healthcare workers. This study aims to assess the effectiveness of training in RVV introduction in enhancing the knowledge of the participants. Methods: The study was conducted among the participants attending two training workshops for the introduction of RVV: a state workshop in Pune and a regional workshop in Guwahati. The participants who attended the workshops and participated in both the pre- and post-test were included in the study. Real-time data was collected via Google forms pre- and post-training sessions. Results: In both workshops, a comparison of pre- and post-test scores of all questions taken together showed a significant increase in the knowledge level of theparticipants (p < 0.05). In Guwahati, the knowledge of the participants regarding doses of RVV, inadequate dosing, vaccine vial monitor (VVM), open vial policy, operationalization of RVV and monetary incentive increased significantly. In Pune, the knowledge of the participants regarding doses of RVV, bundling approach, schedule and dose, storage temperature for RVV, VVM, open vial policy, vaccine delivery and operationalization of RVV increased significantly after the training. Conclusion: A pre-planned and well-designed knowledge assessment tool can be used to understand the impact of training workshops in enhancing the knowledge and practical skills of the participants prior to the introduction of a new vaccine.&nbsp

Improved infrared photoluminescence characteristics from circularly ordered self-assembled Ge islands

The formation of circularly ordered Ge-islands on Si(001) has been achieved because of nonuniform strain field around the periphery of the holes patterned by focused ion beam in combination with a self-assembled growth using molecular beam epitaxy. The photoluminescence (PL) spectra obtained from patterned areas (i.e., ordered islands) show a significant signal enhancement, which sustained till 200 K, without any vertical stacking of islands. The origin of two activation energies in temperature-dependent PL spectra of the ordered islands has been explained in detail

Twist and turn of an unusual entity: A rare case report of torsion of huge epididymal cyst from a tertiary hospital

An epididymal cyst (EC) is a benign lesion. It arises due to cystic degeneration of the epididymis. The torsion of it is extremely rare. The usual presentation of the cyst is asymptomatic scrotal swelling. The swelling has a lobulated surface and feels like a bunch of grapes. The huge EC is rare and moreover, it is associated with torsion-rarest presentation

Impact of Real-time Assessment on the Training of Trainers for the Introduction of Rotavirus Vaccine in India

Background and aim: The introduction of rotavirus vaccine (RVV) in the universal immunization program of India is a big feat as it became the first nation in the World Health Organization (WHO) Southeast Asia region to do so. The involvement of huge numbers of frontline workers in introducing new vaccines in India and the underlined deficits in skills and knowledge require efficient capacity building programs. In view of this, limited research is available on the effectiveness of capacity-building interventions for healthcare workers. There is a dearth of studies from India measuring the “on-spot” impact of immunization trainings on healthcare workers. This study aims to assess the effectiveness of training in RVV introduction in enhancing the knowledge of the participants. Methods: The study was conducted among the participants attending two training workshops for the introduction of RVV: a state workshop in Pune and a regional workshop in Guwahati. The participants who attended the workshops and participated in both the pre- and post-test were included in the study. Real-time data was collected via Google forms pre- and post-training sessions. Results: In both workshops, a comparison of pre- and post-test scores of all questions taken together showed a significant increase in the knowledge level of the participants (p < 0.05). In Guwahati, the knowledge of the participants regarding doses of RVV, inadequate dosing, vaccine vial monitor (VVM), open vial policy, operationalization of RVV and monetary incentive increased significantly. In Pune, the knowledge of the participants regarding doses of RVV, bundling approach, schedule and dose, storage temperature for RVV, VVM, open vial policy, vaccine delivery and operationalization of RVV increased significantly after the training. Conclusion: A pre-planned and well-designed knowledge assessment tool can be used to understand the impact of training workshops in enhancing the knowledge and practical skills of the participants prior to the introduction of a new vaccine