11 research outputs found
Trajectory Aware Macro-cell Planning for Mobile Users
We design and evaluate algorithms for efficient user-mobility driven
macro-cell planning in cellular networks. As cellular networks embrace
heterogeneous technologies (including long range 3G/4G and short range WiFi,
Femto-cells, etc.), most traffic generated by static users gets absorbed by the
short-range technologies, thereby increasingly leaving mobile user traffic to
macro-cells. To this end, we consider a novel approach that factors in the
trajectories of mobile users as well as the impact of city geographies and
their associated road networks for macro-cell planning. Given a budget k of
base-stations that can be upgraded, our approach selects a deployment that
impacts the most number of user trajectories. The generic formulation
incorporates the notion of quality of service of a user trajectory as a
parameter to allow different application-specific requirements, and operator
choices.We show that the proposed trajectory utility maximization problem is
NP-hard, and design multiple heuristics. We evaluate our algorithms with real
and synthetic data sets emulating different city geographies to demonstrate
their efficacy. For instance, with an upgrade budget k of 20%, our algorithms
perform 3-8 times better in improving the user quality of service on
trajectories in different city geographies when compared to greedy
location-based base-station upgrades.Comment: Published in INFOCOM 201
A High-Fat Diet Induces Low-Grade Cochlear Inflammation in CD-1 Mice
There is growing evidence for a relationship between gut dysbiosis and hearing loss. Inflammatory bowel disease, diet-induced obesity (DIO), and type 2 diabetes have all been linked to hearing loss. Here, we investigated the effect of a chronic high-fat diet (HFD) on the development of inner ear inflammation using a rodent model. Three-week-old CD-1 (Swiss) mice were fed an HFD or a control diet for ten weeks. After ten weeks, mouse cochleae were harvested, and markers of cochlear inflammation were assessed at the protein level using immunohistochemistry and at the gene expression level using quantitative real-time RT-PCR. We identified increased immunoexpression of pro-inflammatory biomarkers in animals on an HFD, including intracellular adhesion molecule 1 (ICAM1), interleukin 6 receptor α (IL6Rα), and toll-like-receptor 2 (TLR2). In addition, increased numbers of ionized calcium-binding adapter molecule 1 (Iba1) positive macrophages were found in the cochlear lateral wall in mice on an HFD. In contrast, gene expression levels of inflammatory markers were not affected by an HFD. The recruitment of macrophages to the cochlea and increased immunoexpression of inflammatory markers in mice fed an HFD provide direct evidence for the association between HFD and cochlear inflammation