Whole-brain white matter FA according to outcome assessment aged 3½ years.

<p>p value maps are displayed as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087874#pone-0087874-g002" target="_blank">Figure 2</a>, only using those with 3½ year outcome data for group-wise comparisons. Low Bayley III = infants with scores below predefined cut-offs for Bayley III (<82 for composite motor score, <85 for composite cognitive score); Slow head growth = isolated slow head growth (fall in head circumference centile from birth to follow-up of >2 standard deviations), with otherwise normal neurological examination and Bayley III scores.</p

Early childhood outcomes of infants according to Sarnat neonatal encephalopathy staging.

<p>Values are frequency (% of n);</p><p>*Normal outcome defined as Bayley III cognitive score ≥85 and motor composite score ≥82; with normal head growth; normal neurological examination; normal vision and hearing; and no ongoing seizures at 3½ years.</p

Whole-brain white matter FA according to perinatal clinical assessment.

<p>p value maps are displayed as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087874#pone-0087874-g002" target="_blank">Figure 2</a>. Neuro = neurological; Ther. hypotherm. = therapeutic hypothermia.</p

Additional file 4: of Hypothermia for encephalopathy in low and middle-income countries (HELIX): study protocol for a randomised controlled trial

SPIRIT checklist. (PDF 77 kb