Synthesis, characterization and antimicrobial activity of some new Baylis-Hillman derived benzothiazolo pyrimidinone derivatives

217-227<span style="font-size:10.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-bidi-font-family:="" mangal;mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-US">A series of Baylis–Hillman derived 22 new benzothiazolo pyrimidinone derivatives have been synthesized from Baylis-Hillman acetates and 2-amino benzothiazole under neat conditions with high yields. All the newly synthesized compounds have been characterized by their spectral data and evaluated for their antibacterial and antifungal activity. Among the 22 new benzothiazolo pyrimidinone compounds, 3o which is having fluoro group at ortho position of phenyl ring has shown excellent activity against gram-positive as well as gram-negative bacteria. Compounds 3f, <b style="mso-bidi-font-weight: normal">3m, 3q exhibit good antibacterial activity compared to the remaining compounds. Among all the compounds, 3o has good antifungal activity and compounds 3f, 3h,<b style="mso-bidi-font-weight: normal"> 3k, 3m, 3q and 3s exhibit comparable antifungal activity. The presence of bezothiazolo pyrimidinone moiety along with-F,-Cl,-CF3 and isopropyl substituent groups on the phenyl ring plays a significant role towards antimicrobial activity.</span