Waste Reduction at the Source and Waste Recycle through Briquetting of the Reduction Charge in the black- ash process

Physical losses of material as flue dust in the oil fired rotary furnaces of black ash process for barite reduction have been arrested using briquetted charge. Similarly fine particles of barium sulphate obtained in the purification of barite could be recycled as a resource by exploiting advantages of catalysis and briquetting techniques

INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Stability indicating LC estimation of ramipril and hydrochlorthiazide in its bulk and tablet formulation

Abstract A simple, rapid and sensitive HPLC method has been developed for the simultaneous determination of Ramipril and Hydrochlorothiazide in their dosage forms. Acetonitrile: Phosphate buffer (0.01 M) adjusted to pH 2.6 with Ophosphoric acid, was used as the mobile phase. A CHROMO Sil C-8 (4.6*250 mm) column was utilized as stationary phase. Detection was affected spectrophotometrically at 210 nm. The method was also applied for the determination of Ramipril in the presence of its degradation products. Linearity ranges for Ramipril and Hydrochlorothiazide were 10-50 and 10-150 mg/ml, respectively. The proposed method was further applied to the analysis of tablets containing the two drugs, the percentage recoveries S.D. (n_5) were 99.66% and, 99.63% for Ramipril and Hydrochlorothiazide respectively

An effective, simple and low-cost pretreatment for culture clarification in tetanus toxoid production

Chemically inactivated tetanus toxin (tetanus toxoid, TT), purified from cultures of a virulent Clostridium tetani strain, is the active pharmaceutical ingredient of anti-tetanus vaccines. Culture clarification for TT production and is usually performed by filtration-based techniques. Final clarification of the culture supernatant is achieved by passage through 0.2 µm pore size filtering membranes. Large particles removal (primary clarification) before final filtration (secondary clarification) reduces costs of the overall clarification process. With this aim, chitosan-induced particle aggregation was assessed as an alternative for primary clarification. Three chitosan variants were tested with similar results. Optimal clarification of culture supernatant was achieved by the addition of 8 mg chitosan per l of culture. Extrapolation analysis of filter sizing results indicate that 100 l of chitosan-treated supernatant can be finally filtered with a 0.6 m2 normal filtration cartridge of 0.45 + 0.2 µm pore size. The clarified material is compatible with current standard downstream processing techniques for TT purification. Thus, chitosan-induced particle aggregation is a suitable operation for primary clarification.Fil: Ávila, Lucía. Ministerio de Salud de la Nación. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud "Doctor Carlos G. Malbrán". Instituto Nacional de Producción de Biológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cascone, Osvaldo. Ministerio de Salud de la Nación. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud "Doctor Carlos G. Malbrán". Instituto Nacional de Producción de Biológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Biscoglio, Mirtha Josefa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Salud de la Nación. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud "Doctor Carlos G. Malbrán". Instituto Nacional de Producción de Biológicos; ArgentinaFil: Fingermann, Matias. Ministerio de Salud de la Nación. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud "Doctor Carlos G. Malbrán". Instituto Nacional de Producción de Biológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin