133 research outputs found

    Prostate cancer outcome in Burkina Faso

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    <p>Abstract</p> <p>Introduction</p> <p>African-American black men race is one of non-modifiable risk factors confirmed for prostate cancer. Many studies have been done in USA among African- American population to evaluate prostate cancer disparities. Compared to the USA very few data are available for prostate cancer in Sub-Saharan African countries. The objective of this study was to describe incident prostate cancer (PC) diagnosis characteristics in Burkina Faso (West Africa).</p> <p>Methods</p> <p>We performed a prospective non randomized patient’s cohort study of new prostate cancer cases diagnosed by histological analysis of transrectal prostate biopsies in Burkina Faso. Study participants included 166 patients recruited at the urology division of the university hospital of Ouagadougou. Age of the patients, clinical symptoms, digital rectal examination (DRE) result, serum prostate-specific antigen (PSA) level, histological characteristics and TNM classification were taking in account in this study.</p> <p>Results</p> <p>166 transrectal prostate biopsies (TRPB) were performed based on high PSA level or abnormal DRE. The prostate cancer rate on those TRPB was 63, 8 % (n=106). The mean age of the patients was 71, 5 years (52 to 86). Urinary retention was the first clinical patterns of reference in our institution (55, 7 %, n = 59). Most patients, 56, 6 % (n = 60) had a serum PSA level over than 100 ng/ml. All the patients had adenocarcinoma on histological study of prostate biopsy cores. The majority of cases (54, 7 % n = 58) had Gleason score equal or higher than 7.</p> <p>Conclusion</p> <p>Prostate cancer is diagnosed at later stages in our country. Very high serum PSA level and poorly differentiated tumors are the two major characteristics of PC at the time of diagnosis.</p

    Stage T1c prostate cancer: defining the appropriate staging evaluation and the role for pelvic lymphadenectomy

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    A good staging system should be able to accurately reflect the natural history of a malignant disease, to express the extent of the disease at the time of diagnosis, and stratify patients in prognostically distinctive groups. The staging system for prostate cancer, as it is today, fails to fulfill these requirements. Approximately one third of the patients who undergo surgery for complete excision of prostate cancer in fact do not have a localize disease. The incidence of tumor at the inked margin may reach 30% for T1 stage and up to 60% for clinical T2b prostate cancer according to comparision with pathologic examination of resected specimen. Several concepts have been recently proposed as a means of improving the accuracy of the available staging system. In this paper, we review current aspects of clinical and pathological staging of prostate cancer, and the importance of these new concepts on the early stages of prostate cancer.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47057/1/345_2005_Article_BF01300182.pd

    Photo-vaporisation de la prostate : plaidoyer pour la chirurgie ambulatoire

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    National audienceObjectifs La photo-vaporisation de la prostate (PVP) est une option thĂ©rapeutique de plus en plus rĂ©pandue dans la chirurgie mini-invasive de l’hypertrophie bĂ©nigne de la prostate. Notre objectif Ă©tait de prĂ©senter les rĂ©sultats de la PVP rĂ©alisĂ©e en chirurgie ambulatoire comparĂ© Ă  celle rĂ©alisĂ©e en ambulatoire en dĂ©but d’expĂ©rience. MĂ©thodes Les donnĂ©es prĂ©-, per- et postopĂ©ratoires de 531 patients opĂ©rĂ©s par PVP (Greenlightℱ AMS, États-Unis) dans deux institutions ont Ă©tĂ© collectĂ©es. Pour chaque opĂ©rateur, seuls les patients traitĂ©s en dĂ©but d’expĂ©rience (moins de 100 procĂ©dures) ont Ă©tĂ© inclus dans l’analyse. Pour comparer les complications postopĂ©ratoires de la PVP, deux groupes ont Ă©tĂ© constituĂ©s en fonction de leurs modalitĂ©s d’hospitalisation : groupe 1 (ambulatoire, n = 66) et groupe 2 (hospitalisation, n = 479). Les tests de Student et de Chi2 ont Ă©tĂ© respectivement utilisĂ©s pour comparer les variables continues et catĂ©gorielles avec le logiciel IPSSℱ (IBMℱ, États-Unis) version 20. RĂ©sultats Les patients opĂ©rĂ©s en ambulatoire Ă©tait moins ĂągĂ©s (69 ± 8 vs. 72 ± 9 ans, p = 0,007) et avec moins de comorbiditĂ©s (ASA : 1,55 ± 0,6 vs. 2,06 ± 0,7 p = 0,001) mais avaient des volumes prostatiques, des dĂ©bimĂ©trie et scores fonctionnels (IPSS, QdV) similaires. Les durĂ©es opĂ©ratoires sont plus allongĂ©es chez les patients hospitalisĂ©s (p = 0,001). En revanche, les durĂ©e de sondage (p = 0,937), le taux de conversion en monopolaire (p = 0,52), le taux de complications postopĂ©ratoires (p = 0,32) et le nombre de rĂ©intervention (0,97) n’étaient pas statistiquement diffĂ©rents. Conclusion La photo-vaporisation de la prostate est rĂ©alisable en chirurgie ambulatoire avec une sĂ©curitĂ© suffisante mĂȘme en dĂ©but d’expĂ©rience. MalgrĂ© l’ñge avancĂ© et les morbiditĂ©s compĂ©titives qui constituent des freins Ă  la chirurgie ambulatoire, les patients hospitalisĂ©s n’avaient ni plus de complications postopĂ©ratoires ni plus de rĂ©interventions que les patients opĂ©rĂ©s en ambulatoir
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