Clinical and bacteriological study of neonatal septicaemia in a tertiary care hospital

Background: Neonatal sepsis is a clinical syndrome of bacteraemia characterized by systemic signs and symptoms in the first month of life. It is the leading causes of neonatal mortality and morbidity. Early diagnosis and treatment with appropriate antibiotics is important to improve the prognosis of neonatal sepsis. Our objectives were to study the organisms causing neonatal septicaemia, associated risk factors, to correlate CRP with blood culture and to study mortality rate in neonatal septicaemia.Methods: The study of 2 years included clinically suspected cases of neonatal septicaemia admitted in NICU. 566 blood samples were collected, processed and isolates were identified. Maternal and neonatal risk factors were studied. CRP test was done by slide agglutination test.Results: Blood culture was positive in 205 (36.22%) cases. Among the culture positive cases, 128 (62.44%) were males and 77 (37.56%) females with male to female ratio of 1.66:1. Early onset sepsis was present in 137 (66.83%) and late onset sepsis in 68 (33.17%) cases. 107 (52.20%) were low birth weight babies. The most common neonatal risk factor was prematurity 75 (36.58%) and maternal risk factor was prolonged rupture of membrane 65 (31.71%). gram negative bacilli 144 (70.24%) were found to be common cause of sepsis than gram positive cocci 61 (29.76%), Klebsiella pneumoniae 54 (26.34%) being most common pathogen. Out of 566, CRP test was positive in 244 (43.10%) cases. Mortality rate was 23.41%.Conclusions: Neonatal septicaemia is a life-threatening emergency. The study of etiological profile and CRP test plays a significant role

A solid dispersion based on milk-micelle as a drug-carrier for the enhancement of the aqueous solubility of ritonavir

The goal of present investigation was to evaluate the feasibility of formulating a solid-dispersion using milk-micelles as drug-carriers, to enhance the aqueous solubility of ritonavir

Formulation of a drug-phospholipid complex (Naturosome) to enhance the aqueous solubility of standardized extract of Centella asiastica (SCE)

Purpose: To evaluate the enhancement of aqueous solubility of standardized extract of Centella asiastica, a natural drug with known anti- Alzheimer’s activity, by formulating its complex (Naturosome) with a phospholipid - Phospholipon® 90H

Emotion Recognition by Using Bimodal Fusion

In order to improve the single-mode emotion recognition rate, the bimodal fusion method based on speech and facial expression was proposed. Here emotion recognition rate can be defined as ratio of number of images properly recognized to the number of input images. Single mode emotion recognition term can be used either for emotion recognition through speech or through facial expression. To increase the rate w e combine these two methods by using bimodal fusion. To do the emotion detection through facial expression we use adaptive sub layer compensation ( ASLC) based facial edge detection method and for emotion detection through speech we use well known SVM . Then bimodal emotion detection is obtained by using probability analysis

Finger Knuckle Based Biometric Identifier Using Principal Component Analysis, Feature Extraction and K-NN Classifier

Amidst several biometric measures, the figure knuckle surface is becoming a preferred choice of researchers due to its natural ease of reproducibility and verification. For any purpose of personal identification or crime analysis, figure knuckles surface do not need to be a voluntarily presented, they get exposed naturally. Specific line pattern on the figure knuckle surfaces can be used as effective biometric measure on their own or in combination with other biometrics. Present paper demonstrates the development of a figure knuckle based biometric identification system. The system incorporates principal component analysis (PCA) for feature extraction out of pre-processed and enhanced input image as extracted from knuckle surface video capture. Secondly the system employs k-nn classifier as personal identification algorithm. The system has been tested, verified and validated with many sample test experiments. The paper illustrates the working of the system with detailed intermittent snapshots

The enhancement of the aqueous solubility of ritonavir via formulation of a drug-phospholipid complex

Objective: To evaluate the enhancement of aqueous solubility of a poorly water soluble drug ritonavir by forming its complex with a phospholipid (Phospholipon®90H)

Phyllanthus Niruri: A magic Herb

Medicinal herbs are significant source of pharmaceutical drugs. Latest trends have shown increasing demand of phytodrugs and some medicinal herbs have proven hepatotprotective potential. Inflammation describes a coordinated series of molecular, cellular, tissue, organ, and systemic responses that drive the pathology of various diseases Inflammation is a finely tuned, dynamic, highly-regulated process that is not inherently detrimental, but rather required for immune surveillance, optimal post-injury tissue repair, and regeneration. The inflammatory response is driven by cytokines and chemokines and is partially propagated by damaged tissue-derived products (Damage-associated Molecular Patterns; DAMP’s). DAMPs perpetuate inflammation through the release of proinflammatory cytokines, but may also inhibit anti-inflammatory cytokines

Recovery of Ammonium Nitrate and Reusable Acetic Acid from Effluent Generated during HMX Production

Production of HMX on commercial scale is mainly carried out by modified Bachmann process, and acetic acid constitutes major portion of effluenttspent liquor produced during this process. The recovery of glacial acetic acid from this spent liquor is essential to make the process commercially viable besides making it eco-friendly by minimising the quantity of disposable effluent. The recovery of glacial acetic acid from spent liquor is not advisable by simple distillation since it contains, in addition to acetic acid, a small fraction of nitric acid, traces of RDX, HMX, and undesired nitro compounds. The process normally involves neutralising the spent mother liquor with liquor ammonia and then distillating the ueutralised mother liquor under vacuum to recover dilute acetic acid (strength approx. 30 %). The dilute acetic acid, in turn, is concentrated to glacial acetic acid by counter current solvent extraction, followed by distillation. The process is very lengthy and the energy requirement is also veryhigh, rendering the process economically unviable. Hence, a novel method has been developed on bench-scale to obtain glacial acetic acid directly from the mother liquor after the second ageing process

USE OF HIGH VOLUME FLY ASH ON EARLY AGE SHRINKAGE IN CONCRETE FOR LOCAL HOT AND DRY CONDITION

Recently contractors are demanding a reliable and all-weather partial or full replacement material for sand due to government restrictions on natural sand mining from river beds. Many previous studies showed that fly ash as a pozzolanic material is effective for improving the various properties of concrete. Advantages of fly ash as partial replacement of cement in concrete on early age shrinkage are reported in standard literature. However, effect of fly ash as partial replacement of cement and sand in concrete on early age shrinkage is not clearly available in reputed literature. This paper discusses the experimental research carried out on early age shrinkage of concrete mixtures in which cement and sand were partially replaced with high volume class F fly ash. Nine mixes were prepared that is C0-0, C20-0, C40-0, C0-20, C0-40, C20-20, C20- 40, C40-20 & C40-40 by partly replacing cement and sand by fly ash and compared with control concrete at an early age by using shrinkage cone apparatus. Combine replacement up to 40% of cement and 20% sand by fly ash respectively gives the better result than other mixes. Combine replacement 40% cement and 40% sand by fly ash has reduced the shrinkage by 63.13% than the control mix. In general, incorporation of fly ash as a partial replacement of cement and sand reduced the shrinkage properties and adds sustainability to concrete by reducing CO2 emission during cement production

Bianchijev kozmološki model tipa I u Lyrinoj mnogostrukosti

Bianchi type-I cosmological model in Lyra\u27s manifold is obtained assuming a massless scalar field as the source of gravitational field. Some physical and geometrical properties of the model are discussed.Razvili smo Bianchijev kozmološki model tipa I u Lyrinoj mnogostrukosti kada je izvor gravitacijskog polja bezmaseno skalarno polje. Raspravljaju se neka fizička i geometrijska svojstva modela