3,130 research outputs found
Perioperative infection prophylaxis and risk factor impact in colon surgery
Background: A prospective observational study was undertaken in 2,481 patients undergoing elective colon resection in 114 German centers to identify optimal drug and dosing modalities and risk factors for postoperative infection. Methods: Patients were pair matched using six risk factors and divided into 672 pairs (ceftriaxone vs, other cephalosporins, group A) and 400 pairs (ceftriaxone vs. penicillins, group B). End points were local and systemic postoperative infection and cost effectiveness. Results: Local infection rates were 6.0 versus 6.5% (group A) and 4.0 versus 10.5% (group B); systemic infection rates in groups A and B were 4.9 versus 6.3% and 3.3 versus 10.5%, respectively. Ceftriaxone was more effective than penicillins overall (6.8 vs. 17.8%, p < 0.001). Length of postoperative hospital stay was 16.2 versus 16.9 days (group A) and 15.8 versus 17.6 days (group B). Of the six risk factors, age and concomitant disease were significant for systemic infection, and blood loss, rectum resection and immunosuppressive therapy were significant for local infection. Penicillin was a risk factor compared to ceftriaxone (p < 0.0001). Ceftriaxone saved Q160.7 versus other cephalosporins and O416.2 versus penicillins. Conclusion: Clinical and microbiological efficacy are responsible for the cost effectiveness of ceftriaxone for perioperative prophylaxis in colorectal surgery. Copyright (C) 2000 S. Karger AG, Basel
Bond Orientational Order, Molecular Motion and Free Energy of High Density DNA Mesophases
By equilibrating condensed DNA arrays against reservoirs of known osmotic
stress and examining them with several structural probes, it has been possible
to achieve a detailed thermodynamic and structural characterization of the
change between two distinct regions on the liquid crystalline phase digram: a
higher-density hexagonally packed region with long-range bond orientational
order in the plane perpendicular to the average molecular direction; and a
lower-density cholesteric region with fluid-like positional order. X-rays
scattering on highly ordered DNA arrays at high density and with the helical
axis oriented parallel to the incoming beam showed a six-fold azimuthal
modulation of the first order diffraction peak that reflects the macroscopic
bond-orientational order. Transition to the less-dense cholesteric phase
through osmotically controlled swelling shows the loss of this bond
orientational order that had been expected from the change in optical
birefringence patterns and that is consistent with a rapid onset of molecular
positional disorder. This change in motion was previously inferred from
intermolecular force measurements and is now confirmed by NMR.
Controlled reversible swelling and compaction under osmotic stress, spanning a
range of densities between mg/ml to mg/ml, allows
measurement of the free energy changes throughout each phase and at the phase
transition, essential information for theories of liquid-crystalline states.Comment: 14 pages, 3 figures in gif format available at
http://abulafia.mgsl.dcrt.nih.gov/pics.html E-mail: [email protected]
Recent advances in minimally invasive colorectal cancer surgery
Laparoscopy has improved surgical treatment of various diseases due to its limited surgical trauma and has developed as an interesting therapeutic alternative for the resection of colorectal cancer. Despite numerous clinical advantages (faster recovery, less pain, fewer wound and systemic complications, faster return to work) the laparoscopic approach to colorectal cancer therapy has also resulted in unusual complications, i.e. ureteral and bladder injury which are rarely observed with open laparotomy. Moreover, pneumothorax, cardiac arrhythmia, impaired venous return, venous thrombosis as well as peripheral nerve injury have been associated with the increased intraabdominal pressure as well as patient's positioning during surgery. Furthermore, undetected small bowel injury caused by the grasping or cauterizing instruments may occur with laparoscopic surgery. In contrast to procedures performed for nonmalignant conditions, the benefits of laparoscopic resection of colorectal cancer must be weighed against the potential for poorer long-term outcomes of cancer patients that still has not been completely ruled out. In laparoscopic colorectal cancer surgery, several important cancer control issues still are being evaluated, i.e. the extent of lymph node dissection, tumor implantation at port sites, adequacy of intraperitoneal staging as well as the distance between tumor site and resection margins. For the time being it can be assumed that there is no significant difference in lymph node harvest between laparoscopic and open colorectal cancer surgery if oncological principles of resection are followed. As far as the issue of port site recurrence is concerned, it appears to be less prevalent than first thought (range 0-2.5%), and the incidence apparently corresponds with wound recurrence rates observed after open procedures. Short-term (3-5 years) survival rates have been published by a number of investigators, and survival rates after laparoscopic surgery appears to compare well with data collected after conventional surgery for colorectal cancer. However, long-term results of prospective randomized trials are not available. The data published so far indicate that the oncological results of laparoscopic surgery compare well with the results of the conventional open approach. Nonetheless, the limited information available from prospective studies leads us to propose that minimally invasive surgery for colorectal cancer surgery should only be performed within prospective trials
Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man
Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine catabolites and whether (ii) formation of purines in response to vascular clamping (Pringle maneuver) can be attenuated by prior IPC. Methods: 75 patients were randomly assigned to three groups: group I underwent hepatectomy without vascular clamping; group II was subjected to the Pringle maneuver during resection, and group III was preconditioned (10 min ischemia and 10 min reperfusion) prior to the Pringle maneuver for resection. Central, portal venous and arterial plasma concentrations of adenosine, inosine, hypoxanthine and xanthine were determined by high-performance liquid chromatography. Results: Duration of the Pringle maneuver did not differ between patients with or without IPC. Surgery without vascular clamping had only a minor effect on plasma purine transiently increased. After the Pringle maneuver alone, purine plasma concentrations were most increased. This strong rise in plasma purines caused by the Pringle maneuver, however, was significantly attenuated by IPC. When portal venous minus arterial concentration difference was calculated for inosine or hypoxanthine, the respective differences became positive in patients subjected to the Pringle maneuver and were completely prevented by preconditioning. Conclusion: These data demonstrate that (i) IPC increases formation of adenosine, and that (ii) the unwanted degradation of adenine nucleotides to purines caused by the Pringle maneuver can be attenuated by IPC. Because IPC also induces a decrease of portal venous minus arterial purine plasma concentration differences, IPC might possibly decrease disturbances in the energy metabolism in the intestine as well. Copyright (C) 2005 S. Karger AG, Basel
Free Flying Magnetometers as a Demonstration of Micro-spacecraft Technologies
Four Free Flying Magnetometers (FFMs) flew on the Enstrophy sounding rocket launched on February 10, 1999 from Poker Flats Research Range. Each of these FFMs is a highly integrated sensorcraft , containing their own data, attitude determination, telecom, and power systems in addition to a small 3-axis magnetometer. All of this was fit into a package a little bigger than a hockey puck and weighed less than 250 grams. The FFM technology development task was funded by NASA/JPL
Are N=1 and N=2 supersymmetric quantum mechanics equivalent?
After recalling different formulations of the definition of supersymmetric
quantum mechanics given in the literature, we discuss the relationships between
them in order to provide an answer to the question raised in the title.Comment: 15 page
Mrgprd Enhances Excitability in Specific Populations of Cutaneous Murine Polymodal Nociceptors
The Mas-related G protein-coupled receptor D (Mrgprd) is selectively expressed in nonpeptidergic nociceptors that innervate the outer layers of mammalian skin. The function of Mrgprd in nociceptive neurons and the physiologically relevant somatosensory stimuli that activate Mrgprd^-expressing (Mrgprd^+) neurons are currently unknown. To address these issues, we studied three Mrgprd knock-in mouse lines using an ex vivo somatosensory preparation to examine the role of the Mrgprd receptor and Mrgprd+ afferents in cutaneous somatosensation. In mouse hairy skin, Mrgprd, as marked by expression of green fluorescent protein reporters, was expressed predominantly in the population of nonpeptidergic, TRPV1-negative, C-polymodal nociceptors. In mice lacking Mrgprd, this population of nociceptors exhibited decreased sensitivity to cold, heat, and mechanical stimuli. Additionally, in vitro patch-clamp studies were performed on cultured dorsal root ganglion neurons from Mrgprd^(–/–) and Mrgprd^(+/–) mice. These studies revealed a higher rheobase in neurons from Mrgprd^(–/–) mice than from Mrgprd^(+/–) mice. Furthermore, the application of the Mrgprd ligand β-alanine significantly reduced the rheobase and increased the firing rate in neurons from Mrgprd^(+/–) mice but was without effect in neurons from Mrgprd^(–/–) mice. Our results demonstrate that Mrgprd influences the excitability of polymodal nonpeptidergic nociceptors to mechanical and thermal stimuli
Two Qubits in the Dirac Representation
A general two qubit system expressed in terms of the complete set of unit and
fifteen traceless, Hermitian Dirac matrices, is shown to exhibit novel features
of this system. The well-known physical interpretations associated with the
relativistic Dirac equation involving the symmetry operations of time-reversal
T, charge conjugation C, parity P, and their products are reinterpreted here by
examining their action on the basic Bell states. The transformation properties
of the Bell basis states under these symmetry operations also reveal that C is
the only operator that does not mix the Bell states whereas all others do. In a
similar fashion, expressing the various logic gates introduced in the subject
of quantum computers in terms of the Dirac matrices shows for example, that the
NOT gate is related to the product of time-reversal and parity operators.Comment: 11 page
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