Woodcarving: weasel

Carving of a weasel made of wood by Cherokee artisan Isaac Ratlif in the 1970s

Woodcarving: duck

This wood carving was made by Isaac Ratlif, a member of the Eastern Band of Cherokee Indians and Qualla Arts and Crafts Mutual artisan cooperative

Woodcarving: pig

Since the mid-20th century, woodcarving has become a popular craft on the Qualla Boundary. Animals are a favorite motif. This pig, carved from wood, was made by Isaac Ratlif, a member of the Eastern Band of Cherokee Indians

Woodcarving: weasel

Since the mid-20th century, woodcarving has become a popular craft on the Qualla Boundary. Animals are a favorite motif. This weasel, carved from wood, was made by Isaac Ratlif, a member of the Eastern Band of Cherokee Indians

Woodcarving: duck

This wood carving was made by Isaac Ratlif, a member of the Eastern Band of Cherokee Indians and Qualla Arts and Crafts Mutual artisan cooperative

Comparison of Two Virtual Screening Techniques for the Discovery of Novel SERCA Inhibitors

Inhibitors of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA) are valuable tools for the study of the enzyme’s physiological role. They also bear the potential of being developed into a promising new class of anti-cancer agents. Here, we describe the use of two different computational methods to virtually screen a large compound library for novel SERCA inhibitors. Using a docking-based protocol and an approach using recursive partitioning, we screened the same compound library. To test the performance of both screening methods, we took the top-ranked candidates from each screen and measured their inhibitory potencies for SERCA, using bioassays