6 research outputs found
Malignant melanoma: A retrospective series from a regional cancer center in India
Purpose : To present our experience in treating malignant melanoma
patients. Methods and Materials : All melanoma patients treated at the
Department of Radiotherapy, All India Institute of Medical Sciences,
New Delhi, India, from 1995 to 2007 were studied retrospectively. The
endpoints were loco-regional recurrence, distant recurrence,
recurrence-free survival (RFS), and duration of follow-up (DOFU). RFS
and DOFU were analyzed with respect to the factors like age, sex,
tissue of origin, site of disease, number of nodes, lymphadenopathy,
ulceration, stage, and operability to find out any association.
Results : Seventy-two patients were found evaluable with 40 males and
32 females (median age 46.5 years). Eye was the commonest primary site
with visual disturbance as the commonest symptom. Overall, 87% of the
lesions were single, with most of the nonocular lesions presenting in
the advanced stage. During the disease course, regional lymphadenopathy
and distant metastases were seen in 33% and 32% of cases, respectively.
Highest incidence of lymphadenopathy was seen in skin lesions and in
primaries from trunk and extremities. Of all treated patients, 47%
achieved complete response, 18% partial response, and others had either
stable or progressive disease. The median DOFU was 6.2 months. RFS was
studied only in curatively treated cases with a median of 10 months.
Operability at presentation was the only prognostic factor influencing
DOFU. Conclusion : Malignant melanoma is an uncommon disease in India
carrying a lot of morbidity due to late presentation. Its management is
still not clear regarding the optimum use and schedule of treatment
modalities. More prospective studies in the future are required to come
to a definite conclusion
Malignant melanoma: A retrospective series from a regional cancer center in India
Purpose : To present our experience in treating malignant melanoma
patients. Methods and Materials : All melanoma patients treated at the
Department of Radiotherapy, All India Institute of Medical Sciences,
New Delhi, India, from 1995 to 2007 were studied retrospectively. The
endpoints were loco-regional recurrence, distant recurrence,
recurrence-free survival (RFS), and duration of follow-up (DOFU). RFS
and DOFU were analyzed with respect to the factors like age, sex,
tissue of origin, site of disease, number of nodes, lymphadenopathy,
ulceration, stage, and operability to find out any association.
Results : Seventy-two patients were found evaluable with 40 males and
32 females (median age 46.5 years). Eye was the commonest primary site
with visual disturbance as the commonest symptom. Overall, 87% of the
lesions were single, with most of the nonocular lesions presenting in
the advanced stage. During the disease course, regional lymphadenopathy
and distant metastases were seen in 33% and 32% of cases, respectively.
Highest incidence of lymphadenopathy was seen in skin lesions and in
primaries from trunk and extremities. Of all treated patients, 47%
achieved complete response, 18% partial response, and others had either
stable or progressive disease. The median DOFU was 6.2 months. RFS was
studied only in curatively treated cases with a median of 10 months.
Operability at presentation was the only prognostic factor influencing
DOFU. Conclusion : Malignant melanoma is an uncommon disease in India
carrying a lot of morbidity due to late presentation. Its management is
still not clear regarding the optimum use and schedule of treatment
modalities. More prospective studies in the future are required to come
to a definite conclusion
Central nervous system metastases from primary epithelial ovarian cancer
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