EFFECT OF SUBSTITUTION OF WHEAT FLOUR WITH OAT AND BARLEY MEAL ON THE FUNCTIONAL, RHEOLOGICAL AND SENSORY PROPERTIES OF TARHANA

Addition of whole cereal grains’ meal as a source of dietary fibers for the development of tarhana as a value-added functional food was the aim of this study. The effect of substituting wheat flour 72% (WF) with different ratios of whole wheat meal (WWM), oat flakes meal (OFM), whole barley meal (WBM) and mixed-cereal meal (OFM& WBM) on functional, rheological, color and sensorial properties of tarhana samples was determined. Whole cereal grains’ meal showed higher contents of protein, lipids, ash, crude fibers and total phenolic compounds in comparison to wheat flour (72%). pH values of tarhana samples were reduced from 5.22-5.89 to 4.81-5.09 after 72 h. of fermentation. The flow behavior index of tarhana soup samples ranged between 0.11-0.19, indicating the pseudoplasticity of tarhana samples. The higher value of consistency coefficient was recorded for OFM 50% sample followed by WWM 100% sample. Fermentation loss values of tarhana samples ranged between 7.12% for OFM 25% sample and 12.61% for mixed-cereal 50% sample. Substitution of WF in tarhana formulations with whole cereal grains’ meal reduced the yellowness of tarhana samples. Addition of different whole cereal grains’ meal significantly (p<0.05) improved water and oil absorption capacity of tarhana samples. Also, partial substitution of WF with OFM and mixed-cereal meal at ratio of 50% in tarhana recipe has significantly (p<0.05) increased foaming capacity and stability of the final product. The highest values of sensory parameters were observed in Tarhana soups prepared with OFM at ratios of 25& 50%, mixed-cereal meal at 50% and  the control sample. According to the results of this study, it is possible to partially substitute wheat flour with whole cereal grains’ meal in tarhana production in attempt to have a product combining the nutritional value of whole cereal grains and the health benefits of lactic acid bacteria

EXTRACTION AND EVALUATION OF BIOACTIVE COMPOUNDS FROM SOME FRUIT AND VEGETABLE PEELS

Different  research  reports have revealed that food industry by-products can be considered as good sources of potentially valuable bioactive compounds. This study was performed to evaluate the antioxidant capacity of the peel extracts of pomegranate (PoP), mango (MaP), prickly-pear (PrP), Cantaloupe (CaP) and pea (PeP) using different solvent polarity (methanol, ethanol, ethylacetate and water) to particular attention to their content of total phenolics and flavoniods. Among all tested extracts, ethanolic extracts of PoP, MaP and PrP and aqueous extract of CaPand PeP were shown to exhibited a  significant (p≤0.05) highest extraction yield, total phenolic and flavonoid contents and antioxidant capacity (measured by DPPH,ABTS and FRAP methods). The antioxidant capacity of different peel extracts was showed the following descending order, MaP>PoP>PrP>CaP≈ PeP. Also there was a strong positive correlation between the DPPH, ABTS, FRAP values and total phenolic as well as,  flavoniod contents of different peels extracts. Seventeen phenolic compounds were identified and quantified by HPLC-UV analysis in different peel extracts. Galic acid was identified as the major compound  in MaP and PoP extracts, while it was rutin in the case PrP,CaPand PeP extracts. From the results obtained, fruit and vegetable peels can be considered as good sources of valuable bioactive compounds

Risk Factors Associated with Mild Cognitive Impairment аmong Apparently Healthy People and the Role of MicroRNAs

BACKGROUND: Mild cognitive impairment (MCI) is a stage between the expected cognitive decline of normal ageing and the serious decline of dementia. AIM: To identify risk factors and role of miRNAs associated with mild cognitive impairment (MCI) among employees. SUBJECTS AND METHOD: A cross-sectional study was carried out on 186 employees aged between 40 and 65 years. Cognitive function was evaluated using ACEIII, MoCA, and Quick cognitive tests. Medical history and lifestyle were assessed. Family 132 &amp; 134 miRNA expressions were assessed by real-time PCR. RESULTS: MCI was detected among 14 / 186 (7.5%). miRNA 132 expression was the only significant miRNAs to detect MCI with low sensitivity and specificity (70%). The logistic analysis revealed that higher miRNA132 expressions, low monthly intake of; vegetables, unroasted nuts, low education and higher ALT levels were predicting factors for MCI with AOR 1.1 (1.01-3.3), 1.2 (1.04-1.43), 0.8 (0.8-0.98), 2.7 (1.9-7.4) and 1.6 (1.1-2.3) respectively. CONCLUSION: MiRNAs expression showed low sensitivity and specificity in detecting MCI; only miRNA 132 might be used. Several modifiable factors seem to reduce the risk of MCI

Erratum: Inter-comparison of gauge-corrected global satellite rainfall estimates and their applicability for effective water resource management in a transboundary river basin: The case of the Meghna River Basin [Remote Sens, 6, 828 (2018)]doi 10.3390/rs10060828

Erratu

Unilateral erector spinae plane block versus intravenous morphine for postoperative analgesia after Percutaneous nephrolithotomy. A randomized controlled trial

Pain is an everyday challenge during all surgeries and it is a chief postoperative complication, so pain management is a corner stone in anesthetic practice. Percutaneous nephrolithotomy PCNL surgeries are usually associated with acute postoperative pain. Ultrasound guided nerve block is considered a recent technique for pain management. it provides better visualization of the nerves and reduces the risk for complications e.g. unintended injury to adjacent structures. Erector spinae plane (ESP) block is a novel method of delivering postoperative analgesia after PCNL surgery, technique involves injecting local anaesthetic into the interfascial plane between the erector spinae muscle and the transverse processes.and is therefore devoid of major adverse effects like pneumothorax, spinal cord trauma, and hypotension that can occur with other types of blocks like thoracic paravertebral block (TPVB). The goal of this research was to determine the analgesic efficacy and safety of ultrasound-guided ESP. block done at T8 transverse process level in patients undergoing PCNL surgeries for intraoperative and postoperative analgesia

Unilateral Erector Spinae Plane Block Versus Intravenous Morphine for Postoperative Analgesia After Percutaneous Nephrolithotomy. A Randomized Controlled Trial

Pain is an everyday challenge during all surgeries and it is a chief postoperative complication, so pain management is a corner stone in anesthetic practice. Percutaneous nephrolithotomy PCNL surgeries are usually associated with acute postoperative pain. Ultrasound guided nerve block is considered a recent technique for pain management. it provides better visualization of the nerves and reduces the risk for complications e.g. unintended injury to adjacent structures. Erector spinae plane (ESP) block is a novel method of delivering postoperative analgesia after PCNL surgery, technique involves injecting local anaesthetic into the interfascial plane between the erector spinae muscle and the transverse processes.and is therefore devoid of major adverse effects like pneumothorax, spinal cord trauma, and hypotension that can occur with other types of blocks like thoracic paravertebral block (TPVB). The goal of this research was to determine the analgesic efficacy and safety of ultrasound-guided ESP. block done at T8 transverse process level in patients undergoing PCNL surgeries for intraoperative and postoperative analgesia

Plasma microRNAs biomarkers in mild cognitive impairment among patients with type 2 diabetes mellitus.

ObjectivesTo assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them.MethodsThis study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke's Cognitive Examination III (ACE III). Lipid profile, glycated hemoglobin, and miR-128, miR-132, miR- 874, miR-134, miR-323, and miR-382 expressions, using quantitative real-time PCR, were assessed.ResultsMCI was detected among 59/163 (36.2%) patients with T2DM. Plasma expression of miR-132 was significantly higher in T2DM patients with MCI compared to those without MCI and to normal cognitive healthy individuals (median = 2, 1.1 and 1.2 respectively, P ConclusionMCI affects nearly one-third of adult patients with T2DM. A significantly over expression of miR-132 was detected among T2DM with MCI compared to those with normal cognition

Correction: Plasma microRNAs biomarkers in mild cognitive impairment among patients with type 2 diabetes mellitus.

[This corrects the article DOI: 10.1371/journal.pone.0236453.]