Nursing Care for an AMI (Acute Myocardial Infarction) Patient: A Case Study

In the present study, we have presented a case study of a patient with AMI (acute myocardial infarction) undergoing coronary angiography. The diagnosis was made on the basis of clinical, instrumental, and laboratory data. Nursing care is of great importance in the complex treatment of this disease, both preoperatively and postoperatively. To this end, the nurse prepares a plan for nursing care, including the nursing interventions that will help achieve the goal. That plan is a thought construct that involves developing clinical thinking skills, assessing risk situations, and making adequate decisions

Fatty Liver Degeneration In Children: Association With Obstructive Sleep Apnea

Fatty liver degeneration, also termed hepatic steatosis, is a condition in which lipids accumulate in the hepatocytes causing cellular dysfunction and eventually cell death. Hepatic steatosis is diagnosed histologically when liver fat exceeds more than 5% of the liver weight. In adults, fatty liver degeneration is typically associated with excessive alcohol intake as in alcoholic fatty liver disease or with sedentary lifestyle and high-calorie diet as in non-alcoholic fatty liver disease (NAFLD). With the rise of obesity in recent decades, fatty liver disease has become the leading cause of chronic liver disease, not only in adults but in children as well. Besides liver disease, obesity is associated with several conditions among which is obstructive sleep apnea.The aim of this article is to review the pathogenesis of fatty liver degeneration focusing on NAFLD and its relationship with obstructive sleep apnea in children

CFTR Modulator Therapy For Cystic Fibrosis

IntroductionCystic fibrosis (CF) is the most common life-limiting autosomal recessive condition in Caucasians, affecting the respiratory system, digestive tract and all exocrine glands. It is caused by a mutation in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The genetic analysis, in addition to diagnosis, serves to create a modern individual CFTR modulator therapy.Aim: The aim of this article is to do a presentation of products for CFTR modulator therapy, which are available worldwide; introduction to their pharmacokinetic and pharmacodynamic properties; evaluation of the effect of their application.Materials: We have conducted a study of medical literature related to the products for CFTR modulator therapy and review of information on the topic.Results: The use of approved CFTR modulator therapy products in patients suitable for their use (specific genotype) results in an improvement in FEV1 values and body mass index and a reduction in the incidence of exacerbations in these patients.Conclusion: CFTR modulator therapy significantly improves the prognosis and quality of life of cystic fibrosis patients as a result of certain mutations in the CFTR gene. Quality care for other patients with other mutations is especially important so that they can benefit from personalized treatment in the future

Comprehensive Review of Assessment Tools for Nutrition and Feeding Practices in Early Childhood: Applications, Strengths, and Limitations

This narrative review provides a significant contribution to the field of developmental disabilities by providing a comprehensive and up-to-date analysis of the prevalence and patterns of malnutrition in individuals with cerebral palsy. The findings from this study shed light on the high prevalence of malnutrition and associated factors, such as motor impairment severity, functional limitations, feeding difficulties, and socio-demographic factors. By synthesizing the existing literature from global studies, this manuscript enhances our understanding of the complex relationship between malnutrition and cerebral palsy, providing valuable insights for clinicians, researchers, and policymakers. The comprehensive nature of this review, encompassing various continents and countries, helps to identify regional variations in malnutrition prevalence and highlights the need for targeted interventions and tailored nutritional care strategies for individuals with cerebral palsy worldwide

New developments in the diagnostics of celiac disease in children

Gluten enteropathy (or celiac disease) is the most common genetically related nutritional intolerance worldwide. Celiac disease is a multifactorial, autoimmune disease, which is observed in genetically predisposed individuals. It affects both children and adults leading to an atrophy of the small bowel mucosa of a varying degree. The article outlines the conclusion of the last guidelines on the topic. Finally, a summary and a conclusion on the topic are presented

EXTRA- AND INTRACELLULAR ESTERASES INVOLVED IN DIMETHYLTEREPHTHALATE CATABOLISM BY PSEUDOMONAS SP.

The strain Pseudomonas sp. 054, isolated previously from polluted soil, possesses a high biodegrading activity towards the aromatic ester dimethylterephthalate. The ester hydrolyzing activity of the strain was investigated. Two types of esterases, extra- and intracellular, were detected after growth in liquid medium. The enzyme activities were proved in the culture supernatant and in the crude cell extract by the use of a native electrophoresis. The extracellular protein with an esterase activity had a molecular weight of 67 kDa, while the intracellular fraction produced four separate bands with ester hydrolyzing activity

Macrophage activation syndrome after COVID-19 infection in a patient with systemic juvenile idiopathic arthritis

Macrophage activation syndrome is a serious, potentially fatal complication of the systemic form of juvenile idiopathic arthritis. It shares some common characteristics with the multisystem inflammatory disease in children, which is a late complication of SARS-CoV-2 infection in children.We present an 11-year-old girl diagnosed with systemic juvenile idiopathic arthritis who has been diagnosed with macrophage activation syndrome soon after recovering from COVID-19 infection. The patient has developed pronounced thrombotic microangiopathy, a severe complication marked by significant drop in platelets, anaemia combined with low levels of haptoglobin, presence of schistocytes in blood smear, and new onset gross haematuria