Associação entre hormônios sexuais e asma

A relationship between oral contraceptive (OC) use and asthma is controversial and has been observed in previous researches. The objective of this study was to assess the relationship between combined OC use and pulmonary function in Brazilian women with or without asthma, in addition to evaluate the cytokines to verify the inflammatory process of asthma. This was case-control study involving women with and without asthma who were or not using combined OC. Seventy women were recruited from the Family Health Clinic or from the universities and 7 were excluded. Sixty-three patients were divided into four groups (I:-no asthma and no OC use; II:- no asthma and OC use; - III:- asthma and no OC use; and, IV: asthma and OC use). MANOVA (multivariate analysis of variance) were conducted. First one to evaluate the relationship between combined oral contraceptive (OC) use and changes in pulmonary function (FVC, FEV1, FEV1/FVC%) in women with or without asthma. The second MANOVA evaluated the influence of sex hormones on the immune system through the alteration of cytokins expression (IL-4, IL-5, and TNF-?). There was a lack of evidence regarding OC use?s effect on the spirometric parameters (Wilk?s ? = 0.850, F=0.757, p=0.647, ?²=0.053) and on cytokins levels (Wilk?s ? = 0.909, F=0.533, p=0.848, ?²=0.031), even when controlled by covariates. Therefore, this study returned lack of evidences concerning the relation between the use of OC use and alteration in spirometric parameters as well in cytokins dosages.A associação entre o uso de anticoncepcionais e a asma é controversa e foi sugerida em pesquisas prévias. Nesse contexto, o objetivo deste estudo foi avaliar a relação entre anticoncepcionais orais combinados (AOC) e a função pulmonar em mulheres brasileiras com e sem asma, além de avaliação de citocinas para verificar o processo inflamatório da asma. Para esse fim, foi realizada uma pesquisa caso-controle com mulheres com e sem asma e que usavam ou não AOC. Setenta mulheres foram recrutadas de Ambulatórios de Saúde da Família e provenientes de centros universitários e sete foram excluídas. Sessenta e três pacientes foram divididas em quatro grupos: (I:- sem asma e sem AOC; II:- sem asma e com AOC; III:- com asma e sem AOC; IV:- com asma e com AOC). Em relação a avaliação estatística: duas análises MANOVA (análise multivariada de variância) foram realizadas; a primeira avaliou a relação entre o uso de AOC e mudanças na função pulmonar (VEF1, CVF, VEF1/CVF%) em mulheres com e sem asma; a segunda análise avaliou a influência dos hormônios sexuais no sistema imune pela alteração da expressão das citocinas (IL-4, IL-5 e TNF-?). Não houve evidência com relação ao uso de AOC e os parâmetros espirométricos (Wilk?s ? = 0,850, F=0,757, p=0,647, ?²=0,053) e os níveis de citocinas (Wilk?s ? = 0,909, F=0,533, p=0,848, ?²=0,031), mesmo após o controle das covariáveis. Portanto, este estudo não observou evidência de que há relação entre o uso AOC e alterações espirométricas, assim como não há relação entre AOC e alterações dos níveis de citocinas. Descritores: Asma, anticoncepcionais, mulheres, citocinas, espirometria.Dados abertos - Sucupira - Teses e dissertações (2013 a 2016

Prevalence of allergen sensitization, most important allergens and factors associated with atopy in children

CONTEXT AND OBJECTIVE: Knowledge of the profile of allergen sensitization among children is important for planning preventive measures. The objective of this study was to assess the prevalence and profile of sensitization to inhaled allergens and food among children and adolescents in an outpatient population in the city of Palmas. DESIGN AND SETTING: Cross-sectional study at outpatient clinics in Palmas, Tocantins, Brazil. METHODS: Ninety-four patients aged 1-15 years who were attending two pediatric outpatient clinics were selected between September and November 2008. All of the subjects underwent clinical interviews and skin prick tests. RESULTS: A positive skin prick test was observed in 76.6% of the participants (72.3% for inhalants and 28.9% for food allergens). The most frequent allergens were Dermatophagoides pteronyssinus (34%), cat epithelium (28.7%), dog epithelium (21.3%), Dermatophagoides farinae (19.1%), Blomia tropicalis (18.1%), cow's milk (9.6%) and grasses (9.6%). A positive skin prick test correlated with a history of atopic disease (odds ratio, OR = 5.833; P = 0.002), a family history of atopic disease (OR = 8.400; P < 0.001), maternal asthma (OR = 8.077; P = 0.048), pet exposure (OR = 3.600; P = 0.012) and cesarean delivery (OR = 3.367; P = 0.019). CONCLUSION: Dermatophagoides pteronyssinus was the most frequent aeroallergen and cow’s milk was the most prevalent food allergen. There was a positive correlation between a positive skin prick test and several factors, such as a family history of atopic disease, maternal asthma, pet exposure and cesarean delivery