Genetic prediction of ICU hospitalization and mortality in COVID-19 patients using artificial neural networks

There is an unmet need of models for early prediction of morbidity and mortality of Coronavirus disease-19 (COVID-19). We aimed to a) identify complement-related genetic variants associated with the clinical outcomes of ICU hospitalization and death, b) develop an artificial neural network (ANN) predicting these outcomes and c) validate whether complement-related variants are associated with an impaired complement phenotype. We prospectively recruited consecutive adult patients of Caucasian origin, hospitalized due to COVID-19. Through targeted next-generation sequencing, we identified variants in complement factor H/CFH, CFB, CFH-related, CFD, CD55, C3, C5, CFI, CD46, thrombomodulin/THBD, and A Disintegrin and Metalloproteinase with Thrombospondin motifs (ADAMTS13). Among 381 variants in 133 patients, we identified 5 critical variants associated with severe COVID-19: rs2547438 (C3), rs2250656 (C3), rs1042580 (THBD), rs800292 (CFH) and rs414628 (CFHR1). Using age, gender and presence or absence of each variant, we developed an ANN predicting morbidity and mortality in 89.47% of the examined population. Furthermore, THBD and C3a levels were significantly increased in severe COVID-19 patients and those harbouring relevant variants. Thus, we reveal for the first time an ANN accurately predicting ICU hospitalization and death in COVID-19 patients, based on genetic variants in complement genes, age and gender. Importantly, we confirm that genetic dysregulation is associated with impaired complement phenotype.- Pfizer Pharmaceuticals(undefined

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

In an international cohort of 279 patients with hypoxemic influenza pneumonia, we identified 13 patients (4.6%) with autoantibodies neutralizing IFN-alpha and/or -omega, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine. Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-alpha 2 alone (five patients) or with IFN-omega (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-alpha 2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-omega. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients 70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-alpha 2 and IFN-omega (OR = 11.7, P = 1.3 x 10(-5)), especially those <70 yr old (OR = 139.9, P = 3.1 x 10(-10)). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for similar to 5% of cases of life-threatening influenza pneumonia in patients <70 yr old

Imago Libri. Représentations carolingiennes du livre, sous la dir. de Charlotte Denoël, Anne-Orange Poilpré, Sumi Shimahara, Turnhout, 2018 (Bibliologia 47), 266 p., 355 ill.

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Un évêque bibliophile à la cour de Cilicie: Jean (Yovhannēs), né Baudoin, frère du roi Hét'um Ier

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Le Proche-Orient, creuset de traditions et source d'images chrétiennes

International audienceBerceau du christianisme, le monde proche-oriental a constitué une matrice où l’imaginaire chrétien s’est exprimé à travers des symboles et des représentations bibliques. Ces images ont rayonné dans tout le Bassin méditerranéen où les traditions religieuses et artistiques n’ont cessé de se croiser sur les routes de pèlerinage et de commerce

Un nouveau témoignage sur l’empire des Grands Comnènes: la date des fresques de la chapelle Saint-Élie au monastère de Vazélon

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et Anne-Orange Poilpré, Narration et speculum principis

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Ernst Kitzinger, Le culte des images avant l'iconoclasme (IVe-VIe siècles), traduction et postface par Philippe-Alain Michaud, Paris, éditions Macula, 2019

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Notices dans le catalogue de l'exposition Gabrijel Mije i istraživanja stare srpske arhitekture [Gabriel Millet et les recherches sur l'architecture serbe ancienne]

notices de présentation de photographies patrimoniale