1,021 research outputs found
Collective Charge Fluctuations in Single-Electron Processes on Nano-Networks
Using numerical modeling we study emergence of structure and
structure-related nonlinear conduction properties in the self-assembled
nanoparticle films. Particularly, we show how different nanoparticle networks
emerge within assembly processes with molecular bio-recognition binding. We
then simulate the charge transport under voltage bias via single-electron
tunnelings through the junctions between nanoparticles on such type of
networks. We show how the regular nanoparticle array and topologically
inhomogeneous nanonetworks affect the charge transport. We find long-range
correlations in the time series of charge fluctuation at individual
nanoparticles and of flow along the junctions within the network. These
correlations explain the occurrence of a large nonlinearity in the simulated
and experimentally measured current-voltage characteristics and non-Gaussian
fluctuations of the current at the electrode.Comment: 10 pages, 7 figure
Widening use of dexamethasone implant for the treatment of macular edema
Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis. The implant is formulated in a biodegradable copolymer to release the active ingredient within the vitreous chamber for up to 6 months after an intravitreal injection, allowing a prolonged interval of efficacy between injections with a good safety profile. Various other ocular pathologies with inflammatory etioÂpathogeneses associated with macular edema have been treated by DEX implant, including neovascular age-related macular degeneration, Irvine–Gass syndrome, vasoproliferative retinal tumors, retinal telangiectasia, Coats’ disease, radiation maculopathy, retinitis pigmentosa, and macular edema secondary to scleral buckling and pars plana vitrectomy. We undertook a review to provide a comprehensive collection of all of the diseases that benefit from the use of the sustained-release DEX implant, alone or in combination with concomitant therapies. A MEDLINE search revealed lack of randomized controlled trials related to these indications. Therefore we included and analyzed all available studies (retrospective and prospective, comÂparative and non-comparative, randomized and nonrandomized, single center and multicenter, and case report). There are reports in the literature of the use of DEX implant across a range of macular edema-related pathologies, with their clinical experience supporting the use of DEX implant on a case-by-case basis with the aim of improving patient outcomes in many macular pathologies. As many of the reported macular pathologies are difficult to treat, a new treatÂment option that has a beneficial influence on the clinical course of the disease may be useful in clinical practice
Signatures of Wigner Localization in Epitaxially Grown Nanowires
It was predicted by Wigner in 1934 that the electron gas will undergo a
transition to a crystallized state when its density is very low. Whereas
significant progress has been made towards the detection of electronic Wigner
states, their clear and direct experimental verification still remains a
challenge. Here we address signatures of Wigner molecule formation in the
transport properties of InSb nanowire quantum dot systems, where a few
electrons may form localized states depending on the size of the dot (i.e. the
electron density). By a configuration interaction approach combined with an
appropriate transport formalism, we are able to predict the transport
properties of these systems, in excellent agreement with experimental data. We
identify specific signatures of Wigner state formation, such as the strong
suppression of the antiferromagnetic coupling, and are able to detect the onset
of Wigner localization, both experimentally and theoretically, by studying
different dot sizes.Comment: 4 pages, 4 figure
One-body dissipation and chaotic dynamics in a classical simulation of a nuclear gas
In order to understand the origin of one-body dissipation in nuclei, we
analyze the behavior of a gas of classical particles moving in a
two-dimensional cavity with nuclear dimensions. This "nuclear" billiard has
multipole-deformed walls which undergo periodic shape oscillations. We
demonstrate that a single particle Hamiltonian containing coupling terms
between the particles' motion and the collective coordinate induces a chaotic
dynamics for any multipolarity, independently on the geometry of the billiard.
If the coupling terms are switched off the "wall formula" predictions are
recovered. We discuss the dissipative behavior of the wall motion and its
relation with the order-to-chaos transition in the dynamics of the microscopic
degrees of freedom.Comment: 16 pages, 12 postscript figures included, revtex, new version
completely revised accepted by Physical Review C and scheduled to appear in
the issue of november 199
A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis
Lactobacilli with probiotic features play an essential role in maintaining a balanced vaginal microbiota and their administration has been suggested for the treatment and prevention of vaginal dysbiosis. The present study was aimed to in vitro and in vivo investigate the probiotic potential of the Lacticaseibacillus rhamnosus TOM 22.8 strain, isolated from the vaginal ecosystem of a healthy woman. For this purpose, safety and functional properties were in depth evaluated. The strain exhibited a broad spectrum of antagonistic activity against vaginal pathogens; adhesion capacity to both the vaginal VK2/E6E7 and the intestinal Caco-2 cells; anti-inflammatory and antioxidant activities, suggesting its promising probiotic features. In addition, an in vivo pilot-study was planned. Based on both clinical and microbiological parameters, the oral or vaginal strain administration, determined a significant pathogens reduction after 10 days of administration and a maintenance of eubiosis up to 30 days after the end of the treatment. Therefore, the L. rhamnosus TOM 22.8 strain can be proposed as valuable oral and/or vaginal treatment for vaginal dysbiosis
Exchange Frequencies in the 2d Wigner crystal
Using Path Integral Monte Carlo we have calculated exchange frequencies as
electrons undergo ring exchanges in a ``clean'' 2d Wigner crystal as a function
of density. The results show agreement with WKB calculations at very low
density, but show a more rapid increase with density near melting. Remarkably,
the exchange Hamiltonian closely resembles the measured exchanges in 2d He.
Using the resulting multi-spin exchange model we find the spin Hamiltonian for
r_s \leq 175 \pm 10 is a frustrated antiferromagnetic; its likely ground state
is a spin liquid. For lower density the ground state will be ferromagnetic
Chaotic Scattering in Heavy--Ion Reactions
We discuss the relevance of chaotic scattering in heavy--ion reactions at
energies around the Coulomb barrier. A model in two and three dimensions which
takes into account rotational degrees of freedom is discussed both classically
and quantum-mechanically. The typical chaotic features found in this
description of heavy-ion collisions are connected with the anomalous behaviour
of several experimental data.Comment: 35 pages in RevTex (version 3.0) plus 27 PostScript figures
obtainable by anonymous ftp from VAXFCT.CT.INFN.IT in directory kaos. Fig. 1
upon request to the authors. To be published in the October Focus issue on
chaotic scattering of CHAO
Effect of filtering in dense WDM metro networks adopting VCSEL-based multi-Tb/s transmitters
Long-wavelength vertical cavity surface emitting lasers (VCSELs) can represent an alternative solution for the development of transmitters with reduced cost, power consumption and footprint for very-high capacity metropolitan area systems. Multi-Tb/s transmitter modules with fine wavelength division multiplexing (WDM) granularity can be obtained adopting direct modulation (DM) with advanced modulation formats, such as discrete multitone (DMT), and aggregating multiple DM-VCSELs emitting in the C-band with WDM multiplexers in SOI chips. Due to numerous hops between nodes inside metropolitan area networks the effect of filtering can severely impact the transmission performance; we evaluate the transported capacity in function of nodes number taking into account the actual VCSEL parameters and simplified coherent detection
A rare case of suicide by ingestion of phorate: A case report and a review of the literature
Phorate is a systemic organophosphorus pesticide (OP) that acts by inhibiting cholinesterases. Recent studies have reported that long-term low/moderate exposure to OP could be correlated with impaired cardiovascular and pulmonary function and other neurological effects. A 70-year-old farmer died after an intention ingestion of a granular powder mixed with water. He was employed on a farm for over 50 years producing fruit and vegetables, and for about 20 years, he had also applied pesticides. In the last 15 years, he used phorate predominantly. The Phorate concentration detected in gastric contents was 3.29 µg/mL. Chronic exposure to phorate is experimentally studied by histopathological changes observed in the kidney. In the light of current literature, our case confirms that there is an association between renal damage and chronic exposure to phorate in a subject exposed for years to the pesticide. Autopsies and toxicological analyses play a key role in the reconstruction of the dynamics, including the cause of the death
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