Chance in our strands?

In keeping with the spirit of the article on which this perspective is based, a coin was tossed to decide the order of authors

Factors Affecting International Students’ Perception of Their Academic Learning Experiences at Northeast Normal University China

With the increasing number of international students travelling to well-developed countries for higher education, such as the China, there has been a growing interest in exploring the factors that influence their academic performance and academic learning experiences during their overseas studies. This study aims to give an insight into international students’ perceptions of academic learning experiences. A quantitative approach was employed to gain a better understanding of international graduate students' perceptions of their academic learning experiences at Northeast Normal University. The sample comprised 87 international students, 44 Master and 43 doctoral from four schools: Education 32, Life Sciences29, Economics15 and Chemistry11. A structured questionnaire, the Dundee Ready Education Environment Measure (DREEM) served as the main instrument for quantitative data collection.Three (3) sampling techniques were used in this study: purposive sampling, stratified sampling and simple random sampling. A five-point Lickert scale (1= Strongly disagree; 2= Disagree; 3= Unsure; 4= Agree; 5= Strongly agree) was involved in the questionnaire instrument. Data was analyzed using the Statistical Package for Social Sciences (SPSS) version 20.0.Findings indicate that students rate most aspects of their programs positively, although few respondents give the highest ratings, indicating that there is substantial room for improvement. International students’ majors and length of stay in China influenced perceptions about the learning environment. Keywords: Factors Affecting, International students, perceptions, Academic learning experience

A Unique Case of Inflow Cannula Obstruction by a Tissue Membrane

The use of a left ventricular assist device has increased and is a primary surgical treatment for heart failure. However, one major complication of left ventricular assist device support is an obstruction in the blood flow pathway. Pump thrombosis and outflow graft occlusion are some of the common causes of such obstructions. Here, we describe a unique case of HeartMate II (Abbott Laboratories) inflow cannula obstruction from a membranous structure without evidence of thrombus. The histology showed evidence of fibrous tissue and heart muscle tissue in the membrane. The patient underwent a successful device exchange with a HeartMate 3 (Abbott Laboratories) and is doing well

English language as a medium of instruction among Pakistani International students in Northeast Normal University

Main aim of this paper was to explore the usage of English Language by way of the source of training among Pakistani International students at Northeast Normal  University. The paper employed qualitative approach; semi-structured interviews were used to assemble facts from 20 international offers an initial representation of the speedily rising worldwide phenomenon of English medium instruction (EMI). English, today emerges because the predominant medium of international tutorial discourse. English is perceived because the key to the socio-cultural advancement.  Almost the student spent more than two hours to self study English, which purpose is to make strong his skill in English.60% agree with a quality of English Language in this school in some aspects, like write, speech, read in the classroom. Working EMI definition: using the English language to train instructional subjects in countries or jurisdictions where the primary language (L1) of most people of the population isn't always English. Key Words: English Language, International Students, Medium of Instruction

Seeing into the Future: HeartMate 3 to the Systemic Right Ventricle in a Completely Blind Patient with Congenitally-corrected Transposition of the Great Arteries

A 24-year-old, blind male with congenitally-corrected transposition of the great arteries and systemic right ventricular failure presented with New York Heart Association class IV heart failure despite home inotropic therapy. He was not a transplant candidate due to psychosocial issues. He underwent a successful HeartMate 3 (Abbott Laboratories) placement with the implementation of techniques to guide home ventricular assist device care despite blindness

Spending Behaviour of Northeast Normal University Students by Using Plastic Money

Plastic money is precious financial instrument which is being used to place of money due to its easiness. It bases on bank ATM, debit and credit cards as well as university and organizations’ cards are also come under it due its payment services. This paper explores the spending behavior of Northeast Normal University, Changchun, students. The students use university cards mostly inside the campus supper markets for shopping and bank cards as well. The questionnaire was used to collect the data. Hypothesis testing are showing that if age increases then the usage of cards increases as compare to hard cash. Furthermore, male has more share in spending than females. Keywords: Plastic money, bank cards, payment solutions, student cards, buying and spending behaviour

ASSESSMENT OF PUBLIC KNOWLEDGE AND ATTITUDE REGARDING ANTIBIOTIC USE IN A TERTIARY CARE HOSPITAL

Objective: The present study was designed to investigate the public knowledge and attitude toward antibiotic use in a general population visiting thetertiary care hospital.Methods: A prospective cross-sectional survey conducted for a period of 6-month December-2013 to May-2014. Knowledge scoring was given basedon the percentage of correct responses. Data were collected using a self-prepared questionnaire and analyzed using descriptive statistics. Associationof respondent's knowledge score with sex, age group, educational level, and income was analyzed by Chi-square test.Results: The results of our study showed that the level of knowledge on antibiotics use was poor in 117 (65%) of the study population who had given<50% correct response. The current study showed that there was a significant difference in knowledge between education level groups (p≤0.0001).The other responses regarding knowledge are 27.2% accepted that antibiotics are indicated for relieving pain and inflammation, 45% of participantsthought that antibiotics are the drugs indicated to reduce fever. About 76.6% of respondents had administered antibiotics without a doctor'sprescription, 44% of respondents used antibiotics with their friends and family member's suggestions. 48% of respondents keep antibiotics stockat home for future use and 79.4% of respondents keep leftover antibiotics for personal future use, 31% share their antibiotics with family memberswhen they are sick and 34% of respondents use leftover antibiotics for a respiratory illness.Conclusion: Patients, as well as healthcare professionals, have a major role to play in attaining rational antibiotic use. Antibiotic awareness campaignsand patient counseling should promote specific messages to public members from the high risk†groups, to fill up the knowledge and attitude gaps.Keywords: Antibiotic use, Self-medication, Attitude, Miss-use, Awareness, Microbial resistance

551 Pegasus Skin, a study of SAR444245 (THOR-707, a pegylated recombinant non-alpha IL2) with cemiplimab for the treatment of participants with advanced unresectable or metastatic skin cancers

BackgroundSAR444245 (THOR-707) is a recombinant human IL-2 molecule that includes a PEG moiety irreversibly bound to a novel amino acid via click chemistry to block the alpha-binding domain while retaining near-native affinity for the beta/gamma subunits. In animal models, SAR444245 showed anti-tumor benefits, but with no severe side effects, both as single agent and when combined with anti-PD1 comparing with historical data from aldesleukin. The HAMMER trial, which is the FIH study, shows preliminary encouraging clinical results: initial efficacy and safety profile with SAR444245 monotherapy and in combination with pembrolizumab supporting non-alpha preferential activity, validating preclinical models. The Pegasus Skin Phase 1/2 study will evaluate the clinical benefit of SAR444245 in combination with cemiplimab (anti-PD1) for the treatment of participants with cutaneous squamous cell carcinoma (CSCC) or melanomaMethodsPegasus Skin (NCT04913220) will enroll approximately 80 participants in 2 separate cohorts. In cohort A, participants with a locally advanced, unresectable or metastatic melanoma will receive SAR444245 + cemiplimab as first line (1L) therapy. In cohort B, participants with locally advanced or metastatic CSCC who have not received moe than 2 prior lines of systemic therapy and are not candidates for curative surgery or radiation will receive SAR444245 + cemiplimab. The study will start with a dose escalation to determine the recommended phase 2 dose (RP2D) of SAR444245 when combined with cemiplimab. The starting dose will be 16 μg/kg Q3W (DL1) with a possibility to de-escalate to 8 μg/kg Q3W (DL -1) or escalate to 24 μg/kg Q3W (DL2) based on the occurrence of DLT and overall assessment of safety. Participants enrolled in the Dose Escalation and treated at the RP2D selected for Dose Expansion will be included in the total number of participants for efficacy and safety evaluation. Participants will receive study treatment until disease progression, unacceptable toxicity, or completion of 35 cycles. Cemiplimab will be administered 350 mg per label, Q3WAcknowledgementsThe Pegasus Skin study is sponsored by SanofiTrial RegistrationNCT04913220Ethics ApprovalAll applicable ECs are obtainedConsentAll participant consents are obtaine

Knowledge, attitudes and practices regarding dengue fever among adults of high and low socioeconomic groups

OBJECTIVE: To ascertain the knowledge, attitudes and practices of selected adult population in Pakistan regarding Dengue Fever.METHODS: A cross sectional survey was conducted among selected communities with different socio-economic backgrounds in Karachi, Pakistan. A sample size of 440 adults (aged 18 years and above) were interviewed using a pre-tested questionnaire regarding their knowledge, attitude and practices about dengue fever. A composite scoring system, based on the answers given in the questionnaire, was used to establish the level of awareness in the population. The division of the higher and lower socio-economic groups was based on their income and locality; both these variables were determined as a part of our survey.RESULTS: Data from 400 respondents (244 males, 156 females) was used for primary analysis. About thirty five percent of the sample had adequate knowledge about dengue fever and its vector. Knowledge had significant associations with education (p = 0.004) and socioeconomic status (p = 0.02). The high socioeconomic group showed better preventive practices.CONCLUSION: Knowledge of dengue is inadequate in the low socioeconomic class. Better preventive practices against the vector are prevalent in the high socioeconomic group. Hence, a greater focus should be accorded to the low socioeconomic areas in future health campaigns

Psychological Drivers of Alternative Fuel Vehicles' Adoption and Ecologically Responsible Use

Environmental problems caused by global warming are becoming alarming with every passing day. To curb greenhouse gas (GhG) emissions, promoting alternative fuel vehicles (AFVs) and sustainable transport mode choices is critical. This study explores the predictors of eco-social purchase, use, and conservation intentions in a developing country by employing an extended model of the theory of planned behaviour (TPB). Using a self-administered survey technique, data were collected from a nationally representative sample of 1372 customers of three leading automobile manufacturers from eight big cities of Pakistan. Partial Least Squares Structural Equation Modelling (PLS-SEM) was applied to test the measurement and structural models. Results showed that the extended model of TPB received support in the context of Pakistani culture and for the targeted behaviours related to eco-social purchase, use, and conservation intentions concerning AFVs. Implications for marketers and theoretical contribution are discussed at the end