Synthesis, Characterization and Biological Activities of a New 5-Chloroisatin Schiff Base and its Metal Complexes

Copper(II), cobalt(II), nickel(II) and zinc(II) complexes of 5-chloroisatin Schiff base (L) (L= Schiff base derived from 5-chloroisatin and 2-methyl-4- nitro aniline) were synthesized and characterized. The authenticity of the ligand and its metal complexes had been established by micro analysis, IR, NMR, LC/MS, UV-Vis and electrical conductance measurements. The ligand acts as a bidentate in which the carbonyl oxygen and the azomethine nitrogen of 5-chloroisatin are involved in co-ordination. Square planar geometry was proposed for Cu(II) and Ni(II) complexes and tetrahedral geometry was proposed for Co(II) and Zn(II) complexes. The ligand and its metal complexes have been screened for their antibacterial activity against bacterias viz. Staphylococcus aureus and Escherichia coli etc. and antifungal activity against fungi Aspergillus niger and Aspergillus flavous etc. The activities of both the samples have shown significant and noticeable changes on complexations

Synthesis, characterization and biological activities of a new Isatin Schiff base and its metal complexes

The complexes of Copper(II)​, Cobalt(II)​, Nickel(II) and Zinc(II) of Isatin Schiff base (L) (L = Schiff base derived from Isatin and 2-​methyl-​4-​nitroaniline) were synthesized and characterized. The authenticity of the ligand and its metal complexes had been established by micro anal., IR, NMR, LC​/MS, UV-​VIS and elec. conductance measurements. The ligand acts as a bidentate in which the carbonyl oxygen and the azomethine nitrogen of isatin are involved in co-​ordination. Square planar geometry was proposed for Cu(II) and Ni(II) complexes and tetrahedral geometry was proposed for Co(II) and Zn(II) complexes. The ligand and its metal complexes have been screened for their antibacterial, antifungal and anthelmintic activity. The activities of the samples have shown significant and noticeable changes on complexation

ExtSwap: Leveraging Extended Latent Mapper for Generating High Quality Face Swapping

We present a novel face swapping method using the progressively growing structure of a pre-trained StyleGAN. Previous methods use different encoder decoder structures, embedding integration networks to produce high-quality results, but their quality suffers from entangled representation. We disentangle semantics by deriving identity and attribute features separately. By learning to map the concatenated features into the extended latent space, we leverage the state-of-the-art quality and its rich semantic extended latent space. Extensive experiments suggest that the proposed method successfully disentangles identity and attribute features and outperforms many state-of-the-art face swapping methods, both qualitatively and quantitatively

Identification and classification of detoxification enzymes from Culex quinquefasciatus (Diptera: Culicidae)

Molecular characterization of the insecticide resistance has become a hot research topic ever since the first disease transmitting arthropod (Anopheles gambiae) genome sequence has unveiled in 2002. A recent publication of the Culex quinquefasciatus genome sequence has opened up new opportunities for molecular and comparative genomic analysis of multiple mosquito genomes to characterize the insecticide resistance. Here, we utilized a whole genome sequence of Cx. quinquefasciatus to identify putatively active members of the detoxification supergene families, namely cytochrome P450s (P450s), glutathione-S-transferases (GSTs), and choline/carboxylesterases (CCEs). The Culex genome analysis revealed 166 P450s, 40 GSTs, and 62 CCEs. Further, the comparative genomic analysis shows that these numbers are considerably higher than the other dipteran mosquitoes. These observed speciesspecific expansions of the detoxification super gene family members endorse the popular understanding of the involvement of these gene families in protecting the organism against multitudinous classes of toxic substances during its complex (aquatic and terrestrial) life cycle. Thus, the generated data set may provide an initial point to start with to characterize the insecticide resistance at a molecular level which could then lead the development of an easy to use molecular marker to monitor the incipient insecticide resistance in field environs

The Sheared Central Venous Catheter?

A fractured central venous catheter (CVC) with embolization of the distal fragment may lead to life-threatening complications. We had inserted a right subclavian CVC in a 68-year-old female which upon a follow-up chest X-ray appeared to have been sheared. A guidewire was inserted through the CVC until the J-tip was just beyond the tip of the CVC which were then withdrawn as a single assembly. We suspected that the tip of the guidewire might have been entrapped in the opening of the middle port, which upon withdrawal of the guidewire could have led to CVC folding upon itself and shearing

Boondh: The journey of a raindrop in the drylands

This book gives you glimpses of our work in 13 project sites and also features path breaking initiatives that were successfully implemented at other sites in India

Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy

Sixteen metabolites were quantified from 11-24 micro l volumes in three different brain regions (hippocampus, striatum, and cerebral cortex) during postnatal development. Rat pups from the same litter were repeatedly measured on postnatal days 7, 10, 14, 21, and 28 using a completely noninvasive and longitudinal study design. Metabolite quantification was based on ultra-short echo-time (1)H NMR spectroscopy at 9.4 T and LCModel processing. Most of the brain metabolites were quantified with Cramer-Rao lower bounds (CRLB) less than 20%, which corresponded to an estimated concentration error <0.2 micro mol/g. Taurine and total creatine were quantified with CRLB < or = 5% from all 114 processed spectra. The resulting high reliability and reproducibility revealed significant regional and age-related changes in metabolite concentrations. The most sensitive markers for developmental and regional variations between hippocampus, striatum, and cerebral cortex were N-acetylaspartate, myo-inositol, taurine, glutamate, and choline compounds. Absolute values of metabolite concentrations were in very good agreement with previously published in vitro results based on chromatographic measurements of brain extracts. The current data may serve as a reference for studies focused on developmental defects and pathologies using neonatal rat models

Parasitic Strip Loaded Dual Band Notch Circular Monopole Antenna with Defected Ground Structure

In this article a parasitic strip loaded monopole antennas are designed to notch dual and triple bands. The designed models are constructed on one side of the substrate material and on the other end defected ground structures are implemented. The basic antenna comprises a tuning stub and a ground plane with tapered shape slot as DGS. Another model is constructed with circular monopole radiating element on front side and similar kind of ground structure used in the basic rectangular tuning stub antenna. To create notched bands with tuning stubs, two symmetrical parasitic slits are placed inside the slot of the ground plane. The basic model is of the rectangular stub notching triple band and the circular tuning stub antenna notching dual band. Dual band notched circular tuning stub antenna is prototyped on FR4 substrate and measured results from vector network analyzer are compared with simulation results of HFSS for validation