Asian Journal of Biochemical and Pharmaceutical Research
Abstract
The complexes of Copper(II), Cobalt(II), Nickel(II) and Zinc(II) of Isatin Schiff base (L) (L = Schiff base derived from Isatin and 2-methyl-4-nitroaniline) were synthesized and characterized. The authenticity of the ligand and its metal complexes had been established by micro anal., IR, NMR, LC/MS, UV-VIS and elec. conductance measurements. The ligand acts as a bidentate in which the carbonyl oxygen and the azomethine nitrogen of isatin are involved in co-ordination. Square planar geometry was proposed for Cu(II) and Ni(II) complexes and tetrahedral geometry was proposed for Co(II) and Zn(II) complexes. The ligand and its metal complexes have been screened for their antibacterial, antifungal and anthelmintic activity. The activities of the samples have shown significant and noticeable changes on complexation