33 research outputs found
A randomized, controlled trial of 3.0 mg of liraglutide in weight management
- Author
- Adler J
- Altuntas Y
- Aqua K
- Arechavaleta-Granell Mdel R
- Aronoff Sl
- Astrup Arne
- Astrup Av
- Bach-Kliegel B
- Badat A
- Bain S
- Barakat A
- Bedel Gw
- Berg Sr
- Bilz S
- Blevins Tc
- Blumenau J
- BlĂŒher M
- Bobillo Er
- Brockmyre Ap
- Buscemi S
- Byars Wd
- Call Rs
- Canadas R
- Carraro R
- Caterson I
- Chacra Ar
- Chadha M
- Chandalia H
- Chaykin Lb
- Chetty T
- Chow Fc
- Cohen K
- Conrow Jk
- Csaszar A
- DALLE MOLLE Alberto
- Davis Mg
- de BarbarĂĄ Rg
- de la Cuesta C
- Delibasi T
- Deshmukh Vc
- Deshpande N
- Downey Hj
- Drosman Sr
- Duckor S
- Ellis G
- Farmer H
- Farrell J
- Farsang C
- Fehnel S
- Finneran Mp
- Finucane F
- Forbes R
- Forker A
- Franco Gm
- Franek E
- Fredrick M
- Freijoo Fc
- Fujioka K
- Fujioka Ken
- Geller Sa
- Geloneze Neto B
- Gill S
- Glaser L
- Golay A
- Gonzalez-Galvez G
- Greco Sn
- Greenway Fl
- Greenway Frank
- Gross Jl
- Guler S
- Gurieva I
- Haase Ga
- Halpern A
- Halpern Alfredo
- Hamann A
- Harper W
- Hart R
- Herman L
- Hermansen K
- HjelmesĂŠth J
- Hoekstra J
- Ingebretsen R
- Invitti C
- Ison R
- Jain Rk
- Janzen J
- Jensen Christine Bjorn
- Johannsson-VidarsdĂłttir S
- Kalra S
- Kaplan R
- Karnieli E
- Kaster Sr
- Kerzner B
- Kirstein Jl
- Klemsdal To
- Koltun W
- Krempf M
- Krempf Michel
- Krieger Dr
- Kulseng B
- Kumar S
- Labonte I
- Laederach K
- Lalic N
- Lau D
- Lau David C. W.
- Laville M
- le Roux Carel W.
- Le Roux Cw
- Lean Me
- Lewis Ce
- Lieberman Gs
- Linn T
- Liutkus J
- Ludvik B
- Madder R
- Madsbad S
- Maislos M
- Marchesini G
- Marple Rn
- Marre M
- Martsevich S
- Mcdermott Ej
- Mcgowan B
- Meesters E
- Mello Cj
- Micic D
- Miller Ab
- Mira R
- Mullen J
- Nabriski D
- Nardandrea J
- Nieminen S
- O'Keefe D
- O'Neil P
- Olszanecka-Glinianowicz M
- Ortiz Violante
- Ostrowska L
- Pacini F
- Padwal R
- Pardini A
- Patrick K
- Paulweber B
- Pi-Sunyer F
- Pi-Sunyer Xavier
- Prager R
- Prins J
- Proietto J
- Pucillo Rm
- Pupek-Musialik D
- Ransom Tp
- Raya Pm
- Redrick S
- Rehman T
- Rhee C
- Rissanen A
- Romon M
- Rotella Cm
- Rothman J
- Rubino Dm
- Ruyatkina La
- Santini F
- Sathyapalan T
- Savolainen M
- Scheen A
- Schramm El
- Seeber Me
- Segner A
- Sellers G
- Shehadeh N
- Shimon I
- Shunmugavelu M
- Simon Ja.
- Smith T
- Soufer J
- Startseva Ma
- Stern N
- StĂŒbler P
- Suplicy Hde A
- Suplotova La
- Sussman Am
- Thacker Hp
- Tosch-Sisting R
- Troshina E
- Tytus R
- Ulgen E
- Unnikrishnan A
- van Berkum F
- Van Cleeff M
- Van de Walle V
- Van Gaal L
- Veenendaal A
- Vettor R
- Villiger L
- Violante Ortiz Rm
- Voychik Ea
- Weisnagel Sj
- Wilding J
- Wilding John P. H.
- Wittert G
- Wyatt Hr
- Zahorska-Markiewicz B
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND Obesity is a chronic disease with serious health consequences, but weight loss is difficult to maintain through lifestyle intervention alone. Liraglutide, a glucagonlike peptide-1 analogue, has been shown to have potential benefit for weight management at a once-daily dose of 3.0 mg, injected subcutaneously. METHODS We conducted a 56-week, double-blind trial involving 3731 patients who did not have type 2 diabetes and who had a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of at least 30 or a BMI of at least 27 if they had treated or untreated dyslipidemia or hypertension. We randomly assigned patients in a 2:1 ratio to receive once-daily subcutaneous injections of liraglutide at a dose of 3.0 mg (2487 patients) or placebo (1244 patients); both groups received counseling on lifestyle modification. The coprimary end points were the change in body weight and the proportions of patients losing at least 5% and more than 10% of their initial body weight. RESULTS At baseline, the mean (±SD) age of the patients was 45.1±12.0 years, the mean weight was 106.2±21.4 kg, and the mean BMI was 38.3±6.4; a total of 78.5% of the patients were women and 61.2% had prediabetes. At week 56, patients in the liraglutide group had lost a mean of 8.4±7.3 kg of body weight, and those in the placebo group had lost a mean of 2.8±6.5 kg (a difference of -5.6 kg; 95% confidence interval, -6.0 to -5.1; P<0.001, with last-observation-carried-forward imputation). A total of 63.2% of the patients in the liraglutide group as compared with 27.1% in the placebo group lost at least 5% of their body weight (P<0.001), and 33.1% and 10.6%, respectively, lost more than 10% of their body weight (P<0.001). The most frequently reported adverse events with liraglutide were mild or moderate nausea and diarrhea. Serious events occurred in 6.2% of the patients in the liraglutide group and in 5.0% of the patients in the placebo group. CONCLUSIONS In this study, 3.0 mg of liraglutide, as an adjunct to diet and exercise, was associated with reduced body weight and improved metabolic control. (Funded by Novo Nordisk; SCALE Obesity and Prediabetes NN8022-1839 ClinicalTrials.gov number, NCT01272219.)
ICAR: endoscopic skullâbase surgery
- Author
- Aaron G
- Aaron GP
- Abergel A
- Abouaf L
- Abrishamkar S
- Acioly MA
- Acioly MA
- Acuna RT
- Adams AS
- Adappa ND
- Aferzon M
- Agaimy A
- Agarwal A
- Aggarwal A
- Agrawal D
- Ahmed OH
- Aihara M
- Akagami R
- Alahmadi H
- Albu S
- Albu S
- Albu S
- Alexander A
- Alimohamadi M
- Almefty R
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almond MC
- Alobaid A
- Alobid I
- Alobid I
- Alos L
- AlQahtani A
- Altay T
- Alvarez FL
- Alves MV
- AlâMamgani A
- AlâMefty O
- AlâSheibani S
- Amano K
- Amdur RJ
- Amelot A
- American Academy of Pediatrics Steering Committee on Quality Improvement and Management
- Amichetti M
- Amin SM
- Amit M
- Amit M
- Amit M
- Ammirati M
- Anari S
- Anderson D
- Anderson RL
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- Andrews JC
- Anik I
- Ansa B
- Ansari M
- Antonelli AR
- Arafah BM
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- Solari D
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- Sughrue ME
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- Suzuki K
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- Tosun F
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- Tsirbas A
- Tu GY
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- Turner JH
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- Yano S
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- Yasargil MG
- Ye L
- Yildirim AE
- Yilmazlar S
- Yin ZZ
- Yin ZZ
- Yiotakis I
- Yonezawa K
- Yoo F
- Yoshida E
- Yoshizaki T
- You R
- Youssef AS
- Youssef S
- Yunoue S
- YuâWaiâMan P
- Zacharia BE
- Zada G
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- Zanation AM
- Zanation AM
- Zanation AM
- Zanation AM
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- Zhan R
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- Zoli M
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- Zrebeet HA
- Zuccaro G.
- Zuniga MG
- Zwagerman NT
- Publication venue
- Publication date
- 01/07/2019
- Field of study
n/
The Confrontation between General Relativity and Experiment
- Author
- A Bauch
- A Brillet
- A Coc
- A Coley
- A Eddington
- A Einstein
- A Einstein
- A Einstein
- A Einstein
- A Fienga
- A Godone
- A Gopakumar
- A Hojjati
- A Ivanchik
- A KrĂłlak
- A Milani
- A Nishizawa
- A Nishizawa
- A Paolozzi
- A Stavridis
- AA Geraci
- AA Michelson
- AG Lyne
- AI Shlyakter
- AK Verma
- AM Wolfe
- AO Sushkov
- AP Lightman
- AS Bolton
- AS Eddington
- AS Konopliv
- AT Deller
- B Bertotti
- B Rievers
- B Rossi
- BF Schutz
- BZ Foster
- C Alvarez
- C Alvarez
- C Alvarez
- C Alvarez
- C Alvarez
- C Bambi
- C Braxmaier
- C Cutler
- C Cutler
- C Cutler
- C Deffayet
- C Eling
- C LĂ€mmerzahl
- C Palenzuela
- C Skordis
- C Skordis
- CC Speake
- CD Hoyle
- CD Hoyle
- CH Lineweaver
- CJ Copi
- CK Mishra
- CL Bennett
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- CM Will
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- CM Will
- CM Will
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- CS Reynolds
- CW Chou
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- D Blas
- D Blas
- D Colladay
- D Colladay
- D Kennefick
- D Kennefick
- D Kennefick
- D Mattingly
- D Psaltis
- DB Guenther
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- DE Lebach
- DF Bartlett
- DI Jones
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- DJ Kapner
- DM Eardley
- DM Lucchesi
- DM Lucchesi
- E Barausse
- E Berti
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- E Berti
- E Fischbach
- E Fischbach
- E Fischbach
- E Fischbach
- E Fomalont
- E Gourgoulhon
- E Peik
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- E Poisson
- E Poisson
- E Riis
- E Sagi
- EB Fomalont
- EG Adelberger
- EG Adelberger
- EG Adelberger
- EG Adelberger
- EV Pitjeva
- F Mignard
- F Moura
- FD Ryan
- FJ Dyson
- FJM Farley
- FW Stecker
- G Nordström
- GL Klimchitskaya
- H Asada
- H Chand
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- H MĂŒller
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- I Antoniadis
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- J Alsing
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- JO Dickey
- JP Turneaure
- K Brecher
- K Chatziioannou
- K Hinterbichler
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- M Brunetti
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- M Milgrom
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- MT Murphy
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- N Arkani-Hamed
- N Ashby
- N Ashby
- N Kanekar
- N Leefer
- N Yunes
- N Yunes
- NDR Bhat
- P Antonini
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- P Jaranowski
- P Jaranowski
- P Pani
- P Wolf
- P Wolf
- P Wolf
- PB Demorest
- PCC Freire
- PD Scharre
- PG Roll
- PL Stanwix
- R Dick
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- R Fujita
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- R Mecheri
- R Narayan
- R Quast
- R Srianand
- RA Hulse
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- RH Dicke
- RH Dicke
- RJ Gleiser
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- RP Breton
- RS Lynch
- RS Shankland
- RV Wagoner
- RV Wagoner
- RV Wagoner
- RW Hellings
- RWP Drever
- S Alexander
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- S Bize
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- S Doeleman
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- S Mirshekari
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- SS Shapiro
- SW Hawking
- T AlvÀger
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- T Damour
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- T Damour
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- T Damour
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- T Damour
- T Damour
- T Damour
- T Damour
- T Damour
- T Jacobson
- T Jacobson
- T Jacobson
- T Jacobson
- T Levi-Civita
- T Mitchell
- TA Wagner
- TE Chupp
- TGF Li
- TP Krisher
- TP Krisher
- TP Krisher
- TP Sotiriou
- TP Sotiriou
- TR Taylor
- TS Jaseja
- TW Baumgarte
- TW Murphy
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- V Taveras
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- VA KosteleckĂœ
- VA KosteleckĂœ
- VB Bezerra
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- VI Zakharov
- VW Hughes
- W Sitter de
- W-T Ni
- X-J Bi
- Y Ali-HaĂŻmoud
- Y Fujii
- Y Fujii
- Y Itoh
- Y Mino
- Y Su
- YV Petrov
- Z Marka
- Publication venue
- 'Living Reviews'
- Publication date
- Field of study
Safe LongâRangeTravel for Planetary Rovers through Forward Sensing
- Author
- Publication venue
- ESA Publications Division
- Publication date
- Field of study
Safe Long-Range Travel for Planetary Rovers through Forward Sensing
- Author
- Publication venue
- Publication date
- Field of study
Extent, regional variation and impact of gynecologist payment models in routine pelvic examinations: a nationwide cross-sectional study
- Author
- A Qaseem
- American Institute of Ultrasound in Medicine American College of Radiology, American College of Obstetricians and Gynecologists, Society for Pediatric Radiology, Society of Radiologists in Ultrasound
- Arthur Revhaug
- AS Pahle
- FH Stewart
- Ingard Nilsen
- Ingvild Mathiesen Rosenlund
- JE Wennberg
- JL Benedet
- K Bibbins-Domingo
- LC Baker
- Linda Leivseth
- M Tonelli
- Olav Helge FĂžrde
- SA Schroeder
- SB Ransom
- SS Buys
- T Gosden
- TP Hagen
- VA Moyer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
GENETICS OF ERYTHROPOIESIS:Induced Mutations in Mice and Zebrafish
- Author
- Aplan PD
- Bernstein A
- Boehm T
- Brown L
- Chen Q
- Crossley M
- Dorfman DM
- Driever W
- Feng WC
- Fujiwara KT
- Green AR
- Green AR
- Haffter P
- Hawley RG
- Hwang L-Y
- Johnson SL
- Kallianpur AR
- Kastan MB
- Kelliner MA
- Knapik EW
- Leonard M
- Liao W
- Pardanaud L
- Pevny L
- Ransom DG
- Robb L
- Robb L
- Royer-Pokora B
- Silver L
- Stanier DYR
- Tsai F-Y
- Visvader JE
- Visvader JE
- Weinstein BM
- Weiss MJ
- Wiles MV
- Yamaguchi TP
- Publication venue
- 'Annual Reviews'
- Publication date
- Field of study
Subarachnoid haemorrhage WFNS grade V: is maximal treatment worthwhile?
- Author
- AJ Rosengart
- B Jennett
- Bawarjan Schatlo
- Benjamin Friedrich
- Bernhard Meyer
- CM Fisher
- DS Rosen
- EJ Roos
- ER Ransom
- ES Connolly Jr
- Florian Ringel
- G Lanzino
- G Mohr
- GM Teasdale
- J Claassen
- Karl Schaller
- Kathrin Harmening
- KM Abbed
- M Salary
- M Shimoda
- Maria Wostrack
- Michael Stoffel
- Nora Sandow
- PD Roux Le
- Peter Vajkoczy
- Philippe Bijlenga
- PJ Hutchinson
- R Berg van den
- RU Kothari
- SA Mayer
- SM Russell
- TP Germanson
- Victoria Kehl
- VL Chiang
- WE Hunt
- WI Schievink
- WJ Mack
- Yu-Mi Ryang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Friendships between males and lactating females in a free-ranging group of olive baboons (Papio hamadryas anubis): evidence from playback experiments
- Author
- A. Lemasson
- AP MĂžller
- BB Smuts
- BB Smuts
- C Darwin
- CD Busse
- CD Busse
- CM Anderson
- CP Schaik van
- CP Schaik van
- DA Collins
- DA Collins
- DJ Melnick
- DL Cheney
- DL Cheney
- DM Stein
- FD Burton
- G Arnqvist
- J Altmann
- J Altmann
- JC Avise
- P Marler
- R. A. Palombit
- R. Jubin
- RA Hinde
- RA Palombit
- RA Palombit
- RA Palombit
- RA Palombit
- RA Palombit
- RA Palombit
- RL Trivers
- RM Seyfarth
- S Gouzoules
- SC Strum
- SP Henzi
- T Weingrill
- TJ Bergman
- TP Young
- TR Birkhead
- TW Ransom
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dynamic Volume Changes in Astrocytes Are an Intrinsic Phenomenon Mediated by Bicarbonate Ion Flux
- Author
- A Chvatal
- A Nimmerjahn
- A Panatier
- AA Mongin
- Alexander A. Mongin
- BA MacVicar
- BH Juurlink
- BR Ransom
- CA Pappas
- CB Ransom
- Clare M. Florence
- DD Wang
- DE Bergles
- DG Smith
- DT Theodosis
- E Sykova
- E Sykova
- E Sykova
- E Sykova
- EA Nagelhus
- F Amzica
- F Asztely
- FA Chaudhry
- G Su
- HD Lux
- HK Kimelberg
- HK Kimelberg
- HK Kimelberg
- HK Kimelberg
- I Dietzel
- J Benesova
- J Benesova
- JA Payne
- JC Chen
- JD Cahoy
- JS Diamond
- JW Deitmer
- JW Deitmer
- K Holthoff
- K Kaila
- K Kaila
- KJ Staley
- KP Lehre
- Landon D. Baillie
- LF Agnati
- M Amiry-Moghaddam
- M Amiry-Moghaddam
- M Chesler
- M Obara
- M Pasternack
- MA Dichter
- MO Bevensee
- MO Bevensee
- N Zhou
- NN Haj-Yasein
- P Kofuji
- PG Hirrlinger
- PV Massey
- RD Andrew
- S Nielsen
- Sean J. Mulligan
- SJ Mulligan
- TP Wong
- U Heinemann
- W Walz
- W Walz
- W Walz
- W Walz
- WC Risher
- WC Risher
- Y-F Wang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study