First total synthesis of parvistone C and its C8-epimer

<p>Diastereoselective first total synthesis of parvistone C <b>1</b> and C8-epimer <b>1a</b> are described. The key features of our synthesis include Sharpless asymmetric dihydroxylation, stereoselective aryl Grignard reactions, Still–Gennari olefination, and intramolecular cyclization.</p