Sensitization to indoor aeroallergens in children who attended the Allergy Service of the “Dr. José Eleuterio González” University Hospital of Monterrey, Mexico

Background: Indoor aeroallergens are the main cause of sensitization in children and represent a risk factor for the development of allergic diseases. Objective: Identify the major indoor aeroallergens most often sensitized to pediatric patients treated at the Allergy Service at the “Dr. José Eleuterio González” University Hospital of Monterrey Methods: We performed an observational and descriptive study where we reviewed reports of positive skin tests to the following common indoor aeroallergens: Dermatophagoides farinae (D. farinae), Dermatophagoides pteronyssinus (D. pteronyssinus), Canis familiaris (C. familiaris), Felis domesticus (F. domesticus), Blattella germanica (B. germanica) and Periplaneta americana (P. americana), found in patients under 16 years with symptoms of allergy, during the period of 2011-2012. Results: We performed 439 skin tests to aeroallergens in pediatric patients. Of these, 57.6% were male and 42.4% were female. Mean age was 6.3 years. The age groups were under 3 years: 17.8%, 3-5 years: 35%, 6-12 years: 36%, and 13-16 years: 11.2%. The main diagnoses were: allergic rhinitis (71.8%), asthma (16.6%), and atopic dermatitis (4.3%). In 57.9% of the cases, they had at least one positive skin test to any aeroallergen. The rate of sensitization to speciic aeroallergens was: D. Pteronyssinus 49.0%, D. farinae 44.6%, B. germanica 13.9%, P. Americana 10.9%, F. domesticus 10.7%, and C. familiaris 5.9%. Conclusion: Indoor aeroallergen sensitization can occur early in life, although it was more frequent in the preschooler and elementary school group. Dust house mites were the most commom cause of allergic sensitization

Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

Background: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools. Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following: Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications should be followed; in multi-allergic patients 2 simultaneous injections can be given (100% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50–200% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added. Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico. Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed

Positive autologous serum and plasma skin test prevalence in individuals with chronic idiopathic urticaria

La urticaria cronica es una enfermedad caracterizada por eritema, habones, prurito que aparece diariamente por más de 6 semanas

Evaluación de la función olfatoria en pacientes con rinopatía crónica.

Las enfermedades inflamatorias crónicas de la nariz se asocian con un defecít del flujo de aire y de la conducción en la mucosa olfatoria, por lo que estos procesos patológicos comúnmente se acompañan de disminución de la olfación

Alteraciones timpanométricas en pacientes de 12 a 20 años de edad con rinitis alérgica, atendidos en el Hospital Universitario "Dr. José Eleuterio González", UANL

La rinitis alérgica es un proceso inflamatorio de la mucosa nasal, originado por la exposición a alérgenos en sujetos previamente sensibilizados. Entre los principales padecimientos que se asocian se encuentre la otitis media con efusión, la cual puede dar origen a alteraciones timpanométricas

Sensibilización a aeroalérgenos intradomiciliarios en pacientes pediátricos atendidos en el Servicio de Alergia del Hospital Universitario "Dr. José Eleuterio González", UANL

Los alérgenos intradomiciliaros son la principal causa de sensibilización alérgica en la edad pediátrica, lo cual es un factor de riesgo para el desarrollo de asma y otras enfermedades alérgicas

Angiodema hereditario: Presentación de dos casos

El angiodema hereditario es una enfermedad autosómica dominante, originada por deficiencia del inhibidor de C1, que puede manifestarse con edema facial, laríngeo, genital, intraabdominal o de extremidades

Sensibilización a aeroalérgenos en pacientes adultos atendidos en el Servicio de Alergia del Hospital Universitario "Dr. José Eleuterio González" UANL.

Los aeroalérgenos son la causa mas frecuente de sensibilización alérgica en adultos y tiene un papel prepoderante en la patogénesis de las enfermedades alérgicas respiratorias