2 research outputs found
An Efficient, Scalable Process for Benzphetamine Hydrochloride
Commercial manufacturing of benzphetamine
hydrochloride along with
its impurity profiling is disclosed. Deoxygenation of pseudoephedrine
is reported with ∼100% retention by shielding the amine group
as its <i>tert</i>-butyl carbamate, which is very straightforward
to eliminate at the end. Four unknown process-related impurities are
isolated from the samples of final API and characterized on the basis
of their NMR and mass spectral analysis. Structures of the isolated
impurities are confirmed by independent syntheses and coinjecting
with the isolated one