Empirical Assessment of the Role of Technology-Related Factors and Organization-Related Factors in Electronic Medical Records Implementation Success

The objective of this research was to investigate if certain technology-related and organization-related factors that have most often been associated with successful IT/MIS implementations in other information technology and information science domains are also associated with successful Electronic Medical Records (EMR) implementations. This research uncovered a unique set of technology-related factors and organization-related factors associated with successful EMR implementations from the perspective of healthcare enablers and healthcare providers. Specific technology-related factors considered in this research were the innovativeness of EMR (measured with respect to the relative advantage, compatibility and complexity of EMR), privacy and security attributes of EMR, and usefulness of EMR. Specific organization-related factors considered were the readiness of the organization for change and the !eve! of product/process innovation in the organization where the EMR was implemented

Health Informatics for Healthcare Quality Improvement: A Literature Review of Issues, Challenges and Findings

Healthcare providers in the United States are facing increasing pressures to provide high quality healthcare at affordable prices, while being compliant with a multitude of complex laws. Recent legal developments have highlighted the role of Information Technology and related systems in providing evidence based healthcare in an efficient manner. Health Informatics has become an integral part of the rapidly advancing healthcare technology scenario, and is emerging as a key resource for healthcare quality improvement in the United States. Considering the rapid pace at which the field of health informatics is advancing, it is important for researchers and the practitioners alike to stay abreast of current literature and developments in the field. This literature review paper captures and summarizes from research literature the most significant issues, challenges and findings pertaining to the field of health informatics with a focus on healthcare quality improvement

Does Organizational Innovation Capability Impact Electronic Medical Records Implementation Success?

Innovation capability involves the bringing to the market and/or successful implementation of a new product or service. It is the ability to mobilize the knowledge of the employees and the organization from past experiences to create new knowledge, and use such new knowledge to bring to the market and/or successfully implement a new product or service. Innovation capability is associated with higher levels of product and process innovation within the organization. EMR is considered a technology innovation per research literature. In this research-in-progress paper, we posit that an organization with a high level of innovation capability based on product and process innovation implementations in the past will successfully implement a technology innovation such as an EMR system. A conceptual model is presented with related hypotheses

A Conceptual Model of the Role of Relative Advantage, Compatibility and Complexity in Electronic Medical Records Implementation Success

Successful Electronic Medical Record (EMR) implementation is expected to help control costs and increase efficiencies in healthcare delivery while also improving the quality of care. EMR is an information technology innovation per research literature. It is therefore important that EMR implementations succeed. A large number of information technology implementations fail resulting in monetary and non-monetary losses. EMR implementations in the United States and around the world have been fraught with problems and delays, resulting in unsuccessful or partially successful implementations. Knowing factors that are associated with successful information technology implementations may help EMR implementations succeed. The goal of this research-in-progress is to investigate whether the factors relative advantage, compatibility and complexity, which have most often been associated with successful information technology implementations in other domains such as e-commerce, are also associated with successful EMR implementations

Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex

Ciclopirox (CPX) is an FDA-approved topical antifungal agent that has demonstrated preclinical anticancer activity in a number of solid and hematologic malignancies. Its clinical utility as an oral anticancer agent, however, is limited by poor oral bioavailability and gastrointestinal toxicity. Fosciclopirox, the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract following parenteral administration. We characterized the activity of CPX-POM and its major metabolites in in vitro and in vivo preclinical models of high-grade urothelial cancer. CPX inhibited cell proliferation, clonogenicity and spheroid formation, and increased cell cycle arrest at S and G0/G1 phases. Mechanistically, CPX suppressed activation of Notch signaling. Molecular modeling and cellular thermal shift assays demonstrated CPX binding to γ-secretase complex proteins Presenilin 1 and Nicastrin, which are essential for Notch activation. To establish in vivo preclinical proof of principle, we tested fosciclopirox in the validated N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) mouse bladder cancer model. Once-daily intraperitoneal administration of CPX-POM for four weeks at doses of 235 mg/kg and 470 mg/kg significantly decreased bladder weight, a surrogate for tumor volume, and resulted in a migration to lower stage tumors in CPX-POM treated animals. This was coupled with a reduction in the proliferation index. Additionally, there was a reduction in Presenilin 1 and Hes-1 expression in the bladder tissues of CPX-POM treated animals. Following the completion of the first-in-human Phase 1 trial (NCT03348514), the pharmacologic activity of fosciclopirox is currently being characterized in a Phase 1 expansion cohort study of muscle-invasive bladder cancer patients scheduled for cystectomy (NCT04608045) as well as a Phase 2 trial of newly diagnosed and recurrent urothelial cancer patients scheduled for transurethral resection of bladder tumors (NCT04525131)

Could Negative Perceptions of Information Privacy and Security Impact Health Information Technology (HIT) Implementation Success?

There is a consensus among healthcare professionals and the public about the potential of health information technology (HIT) to make the healthcare system efficient, effective, and safer leading to cost savings in this process, and its ability to pave the way for public health improvement. Among existing health information technologies, electronic medical record (EMR) occupies an important place because of its potential for healthcare monitoring and improvement, especially real-time health monitoring leading to pervasive healthcare. Recent laws in the United States require the implementation and meaningful use of EMR, thereby underlining its importance even further. Information privacy and security issues are increasingly becoming assuming significance with respect to deployment and use of information technology, particularly health information technology, because of the possibility of security breaches involving protected health information (PHI). Healthcare provider and healthcare receiver concerns abound with respect to the information privacy and security offered by health information technology, particularly electronic medical records. This research-in-progress investigates if users’ perceptions about information privacy and security (or lack thereof) in a technology innovation such as EMR plays a role in its successful implementation and subsequent use. Specifically, it investigates whether negative perceptions of information privacy and security will hinder HIT implementation success