Vasectomy reversal and prostate cancer risk: A multi-centre collaborative demonstration project of the Intentional Population Data Linkage Network

This first collaborative demonstration project of the International Population Data Linkage Network (IPDLN) has recently been completed. This project collated data from five data linkage centres across Australia, the United Kingdom and Canada to investigate the effect of vasectomy reversal on prostate cancer risk in vasectomized men. We discuss the study and the challenges of organising and analysing multi-centre linked data studies

The Attitude of Indiana\u27s Congressional Delegation during the Civil War toward Slavery and the Negro: 1861-1865

In this thesis I have examined the attitudes on the Negro question of the members if the Indiana delegation to the Congress of the United States during the period 1861-1865. Two Congresses were is session during this period--the Thirty-seventh and the Thirty-eighth. The Globe and newspapers of the period have been my two primary sources of information. Every shade of opinion was expressed ranging from the utterances of so-called Abolitionist Republican George W. Julian, to the ultra-conservative sentiments voiced by Daniel Voorhees, Democrat

The V Proteins of Simian Virus 5 and Other Paramyxoviruses Inhibit Induction of Interferon-β

AbstractIn this article we show that the paramyxovirus SV5 is a poor inducer of interferon-β (IFN-β). This inefficient induction is a consequence of the expression of an intact viral V protein. In the absence of the viral V protein cysteine-rich C-terminal domain, IFN-β mRNA is strongly induced and the transcription factors NF-κB and IRF-3 are activated significantly. The V protein can work in isolation from SV5 to block intracellular dsRNA signaling. The mechanism of block to dsRNA signaling is distinct from that previously observed for blocking IFN signaling in that proteolysis of candidate factors cannot be detected, and furthermore, the respective blocks require distinct protein domains. Blocking of the induction of IFN-β by dsRNA requires the C-terminal cysteine-rich domain, a feature that is highly conserved among paramyxoviruses. We demonstrate that the V proteins from other paramyxoviruses have equivalent functions and speculate that limiting the yield of IFN-β during infection may be a general property of paramyxoviruses

REACTIVE STRENGTH INDEX-MODIFIED IN DIFFERENT PLYOMETRIC TASKS

The Reactive Strength Index-Modified (RSl,d) is a reliable method of measuring the explosiveness of an athlete during a range of plyometric exercises. The purpose of the current study was to measure the between-limb differences in RSlmod across three different plyometric tasks. Eleven recreationally active participants performed countermovement jumps, stop jumps and single-leg jumps. The study found no significant differences in RSlmod between dominant and non-dominant limbs across all three tasks (p>0.05), but did find RSI,d to be higher in the stop jump than a countermovement jump and single leg stop jump for both dominant and non-dominant limbs. These findings show RSlmod may not be an indicator of limb asymmetry, but may be useful for the coach when looking to develop ex@losive performance in an athlete or performer

REACTIVE STRENGTH INDEX-MODIFIED IN DIFFERENT PLYOMETRIC TASKS

The Reactive Strength Index-Modified (RSlmod) is a reliable method of measuring the explosiveness of an athlete during a range of plyometric exercises. The purpose of the current study was to measure the between-limb differences in RSlmod across three different plyometric tasks. Eleven recreationally active participants performed countermovement jumps, stop jumps and single-leg jumps. The study found no significant differences in RSlmod between dominant and non-dominant limbs across all three tasks (p\u3e0.05), but did find RSI,d to be higher in the stop jump than a countermovement jump and single leg stop jump for both dominant and non-dominant limbs. These findings show RSlmod may not be an indicator of limb asymmetry, but may be useful for the coach when looking to develop exPlosive performance in an athlete or performer

The family mealtime observation study (FaMOS): Exploring the role of family functioning in the association between mothers' and fathers' food parenting practices and children's nutrition risk

This cross-sectional study explores associations between mothers' and fathers' food parenting practices and children's nutrition risk, while examining whether family functioning modifies or confounds the association. Home observations assessed parents' food parenting practices during dinnertime (n = 73 families with preschoolers). Children's nutrition risk was calculated using NutriSTEP®. Linear regression models examined associations between food parenting practices and NutriSTEP® scores. An interaction term (family functioning × food parenting practice) explored effect modification; models were adjusted for family functioning to explore confounding. Among mothers, more frequent physical food restriction was associated with higher nutrition risk in their children (β = 0.40 NutriSTEP® points, 95% Confidence Interval (CI) = 2.30, 7.58) and among both mothers and fathers, positive comments about the target child's food were associated with lower nutrition risk (mothers: β = -0.31 NutriSTEP® points, 95% CI = -0.54, -0.08; fathers: β = -0.27 NutriSTEP® points, 95% CI = -0.75, -0.01) in models adjusted for parent education and child Body Mass Index (BMI) z-score. Family functioning did not modify these associations and they remained significant after adjustment for family functioning. Helping parents to use positive encouragement rather than restriction may help to reduce their children's nutrition risk

Evaluating the Efficacy of Point-of-Use Water Filtration Units in Fiji

Background: To develop and evaluate a strategy for reducing the prevalence and impact of waterborne disease, a water quality intervention was developed for Fiji by Give Clean Water, Inc. in partnership with the Fiji Ministry of Health. Residents were provided and trained on how to use a Sawyer® PointONE™ filter, while also being taught proper handwashing techniques. At the time of the filter installation, all households were surveyed inquiring about the prior 2- to 4-week period. Households were measured a second time between 19 and 225 days later (mean = 66 days). Results: To date, five economic and health outcomes have been tracked on 503 households to evaluate the efficacy of the intervention. When comparing baseline to follow-up among the 503 households, the 2-week diarrhea prevalence decreased in households from 17.5% at baseline to 1.8% at follow-up. Also, the 2-week prevalence of severe diarrhea decreased per household from 9.7% at baseline to 0.6% at follow-up. Finally, monthly diarrhea-related medical costs reduced by an average of Fijian (FJ) $3.54 per person, and monthly water expenses reduced by FJ$0.63 per person. All estimated values are obtained from general linear and logistic mixed-effect models, which adjusted for location, season, time to follow-up, household size, water source, and respondent changing. Changes in economic and health outcomes from installation to follow-up were statistically significant (p \u3c 0.05) in all cases, in both unadjusted and adjusted models. Conclusions: The installation of water filters shows promise for the reduction of diarrhea prevalence in Fiji, as well as the reduction of diarrhea-related medical costs and water expenses. Future work entails evaluation in other countries and contexts, long-term health monitoring, and comparison to alternative water quality interventions