Existence uniqueness and ratio decomposition for Gibbs states via duality

We give an elementary proof of existence and uniqueness of Gibbs states for Hölder weight systems on subshifts of finite type. This uses a notion of duality for such subshifts. The approach of Paterson [2] is used to construct a measure with a prescribed Jacobian and the duality is used to produce an invariant measure from this

Smoothness of holonomies for codimension 1 hyperbolic dynamics

Hyperbolic invariant sets {Lambda} of C1+{gamma} diffeomorphisms where either the stable or unstable leaves are 1-dimensional are considered in this paper. Under the assumption that the {Lambda} has local product structure, the authors prove that the holonomies between the 1-dimensional leaves are C1+{alpha} for some 0 < {alpha} < 1

Rigidity of hyperbolic sets on surfaces

Given a hyperbolic invariant set of a diffeomorphism on a surface, it is proved that, if the holonomies are sufficiently smooth, then the diffeomorphism on the hyperbolic invariant set is rigid in the sense that it is C1+ conjugate to a hyperbolic affine model

Teichmüller spaces and HR structures for hyperbolic surface dynamics

We construct a Teichmüller space for the C^{1+}-conjugacy classes of hyperbolic dynamical systems on surfaces. After introducing the notion of an HR structure which associates an affine structure with each of the stable and unstable laminations, we show that there is a one-to-one correspondence between these HR structures and the C^{1+}-conjugacy classes. As part of the proof we construct a canonical representative dynamical system for each HR structure. This has the smoothest holonomies of any representative of the corresponding C^{1+}-conjugacy class. Finally, we introduce solenoid functions and show that they provide a good Teichmüller space

Do the right thing: experimental evidence that preferences for moral behavior, rather than equity or efficiency per se, drive human prosociality

Decades of experimental research show that some people forgo personal gains to benefit others in unilateral anonymous interactions. To explain these results, behavioral economists typically assume that people have social preferences for minimizing inequality and/or maximizing efficiency (social welfare). Here we present data that are incompatible with these standard social preference models. We use a “Trade-Off Game” (TOG), where players unilaterally choose between an equitable option and an efficient option. We show that simply changing the labelling of the options to describe the equitable versus efficient option as morally right completely reverses the correlation between behavior in the TOG and play in a separate Dictator Game (DG) or Prisoner’s Dilemma (PD): people who take the action framed as moral in the TOG, be it equitable or efficient, are much more prosocial in the DG and PD. Rather than preferences for equity and/or efficiency per se, our results suggest that prosociality in games such as the DG and PD are driven by a generalized morality preference that motivates people to do what they think is morally right

Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors

Microwave irradiation of 2-halobenzonitriles and methyl thioglycolate in the presence of triethylamine in DMSO at 130 °C provides rapid access to 3-aminobenzo[b]thiophenes in 58–96% yield. This transformation has been applied in the synthesis of the thieno[2,3-b]pyridine core motif of LIMK1 inhibitors, the benzo[4,5]thieno[3,2-e][1,4]diazepin-5(2H)-one scaffold of MK2 inhibitors and a benzo[4,5]thieno[3,2-d]pyrimidin-4-one inhibitor of the PIM kinases

A temporal switch model for estimating transcriptional activity in gene expression

Motivation: The analysis and mechanistic modelling of time series gene expression data provided by techniques such as microarrays, NanoString, reverse transcription–polymerase chain reaction and advanced sequencing are invaluable for developing an understanding of the variation in key biological processes. We address this by proposing the estimation of a flexible dynamic model, which decouples temporal synthesis and degradation of mRNA and, hence, allows for transcriptional activity to switch between different states. Results: The model is flexible enough to capture a variety of observed transcriptional dynamics, including oscillatory behaviour, in a way that is compatible with the demands imposed by the quality, time-resolution and quantity of the data. We show that the timing and number of switch events in transcriptional activity can be estimated alongside individual gene mRNA stability with the help of a Bayesian reversible jump Markov chain Monte Carlo algorithm. To demonstrate the methodology, we focus on modelling the wild-type behaviour of a selection of 200 circadian genes of the model plant Arabidopsis thaliana. The results support the idea that using a mechanistic model to identify transcriptional switch points is likely to strongly contribute to efforts in elucidating and understanding key biological processes, such as transcription and degradation

Crucial cross-talk of interleukin-1β and progesterone in human choriocarcinoma

Copyright @ 2012 Spandidos Publications Ltd. This article can be accessed from the links below.This article has been made available through the Brunel Open Access Publishing Fund.Choriocarcinoma is a highly malignant epithelial tumour that is most often associated with hydatidiform mole and presents the most common emergency medical problem in the management of trophoblast disease. We hypothesise that the hormones/cytokines present within the tumour microenvironment play key roles in the development of choriocarcinoma. In this study we assessed the effects of interleukin-1β (IL-1β) on cell death in the presence or absence of the sex hormone progesterone using two choriocarcinoma cell lines (BeWo and JEG-3) as in vitro experimental models. Although IL-1β induced cell death in both cell lines, the effect was more pronounced in JEG-3 cells, where cell death reached 40% compared to 15% in BeWo cells. Cell death of JEG-3 cells in response to IL-1β was significantly decreased by co-treatment with 100 nM and 1000 nM progesterone and completely abolished at a progesterone concentration of 1000 nM. Progesterone was also able to induce phosphorylation of ERK1/2 in these cells. Pretreatment of JEG-3 cells with a specific MAPK inhibitor (UO126) inhibited progesterone's inhibitory effect on cell death. Collectively, these data provide evidence of cross-talk between progesterone and IL-1β in this aggressive and poorly understood tumour that involves activation of a MAPK pathway and involvement of numerous progesterone receptors.This research was funded by a National Institutes of Health Grant ESO12961. This article is made available through the Brunel Open Access Publishing Fund