Data resources in FP/CAC research and learning

The Center for International Reproductive Health Traininghttps://deepblue.lib.umich.edu/bitstream/2027.42/152456/1/RANA_Dec_17_2019_WEBINAR.pdfDescription of RANA_Dec_17_2019_WEBINAR.pdf : Slides (PDF

Defying Borders: The Library's Role in a Global University

http://deepblue.lib.umich.edu/bitstream/2027.42/94434/1/defying_borders_the_librarys_role_in_a_global_university.pd

Global Connections: The Health Sciences Library's Role in Medical Campus Collaborations

http://deepblue.lib.umich.edu/bitstream/2027.42/94437/1/global_connections_the_health_sciences_librarys_role_in_medical_campus_collaborations.pd

Enhancing Faculty Information Skills

http://deepblue.lib.umich.edu/bitstream/2027.42/94439/1/enhancing_faculty_information_skills.pd

A Departmental International Ophthalmology Clearinghouse: Librarian Roles

http://deepblue.lib.umich.edu/bitstream/2027.42/101133/1/global eye poster.pd

Leveraging Librarian Expertise to Support ACGME Competency Education

http://deepblue.lib.umich.edu/bitstream/2027.42/94435/1/leveraging_librarian_expertise_to_Support_ACGME_competency_education.pd

A Proposed Interdisciplinary Workflow to Identify Valuable Electronic Learning Resources

http://deepblue.lib.umich.edu/bitstream/2027.42/94438/1/A_Proposed_Interdisciplinary_Workflow_to_Identify_Valuable_Electronic_Learning_Resources.pd

Eight-module Information Skills Curriculum to Support ACGME Compeetencies

http://deepblue.lib.umich.edu/bitstream/2027.42/94433/1/Eight_module_information_skills_curriculum.pd

A comparative study of efficacy of oral pregabalin and clonidine for attenuation of pressor response to intubation

Background: Endotracheal intubation is associated with hemodynamic stress responses. Various drugs have been used in the past to attenuate the pressor response; however, none has been proved to be ideal. Present study was planned to evaluate the oral pregabalin 150 mg and clonidine 200 µg for attenuation of pressor response to intubation.Methods: The study was conducted on 100 adult patients of either gender scheduled to undergo elective surgeries under general anaesthesia (GA). The patients were randomly allocated into 2 groups. In group A patients received pregabalin 150mg and in group B patients received clonidine 200µg orally. The hemodynamic parameters were recorded until 10 minutes after intubation. The sedation, anxiety and side effects were also assessed.Results: In clonidine group, the mean HR remained below the baseline value at all the time intervals. In pregabalin group, the mean HR remained below the baseline value at most of the time intervals but increased above baseline just after intubation (T0i) and 1 minute after intubation (T1i) where increase was only 1.488±1.20% and 0.45±1.16% respectively from baseline. In both pregabalin and clonidine groups, the mean SBP and MAP remained below the baseline value (Tb) at all the time intervals from T0.5 to T10i. Both clonidine and pregabalin provided adequate anxiolysis and sedation with pregabalin providing more pronounced sedation and anxiolysis than clonidine.Conclusions: Both clonidine and pregabalin are effective oral premedication drugs for attenuation of the pressor response to laryngoscopy and endotracheal intubation.

PARTICLE SIZE REDUCTION OF ACECLOFENAC BY USING SURFACTANTS AND MICRONIZATION FOR NANOCARRIER ENTRAPMENT

The Aceclofenac (2-[(2, 6- dichlorophenyl) amine] phenylacetoxyacetic acid) is a Non-Steroidal Anti-Inflammatory category of drug, which is water insoluble drug of BCS class-II which has low solubility and high permeability phenomenon. The particle size reduction technique is used to solubilize the aceclofenac. The particle size of aceclofenac in bulk form is 140-200 microns. In this experiment, The 35 microns particle size was reduced in powder form from 140-200 microns by using Air jet mill and 17.08 microns size was reduced by using dynomill and 33.62 microns particle size was reduced by using Tween 80 as surfactant as considered as lowest particle size. The Labrasol and Na. CMC were also used in this experiment. The equipments used to reduce particle size of aceclofenac are ultra-Turrax (Ultra-sonication), Air jet mill and Dynomill. These all instruments used to reduce the particle size of aceclofenac are safe and not any chemical compound was added in any of the method described above. This study was used to see the uniform nature of the nano- and micro-particles entrapping the aceclofenac drug obtained by High shear homogenization, high pressure homogenization, Solvent-Diffusion evaporation and membrane contactor methods. If the particle size of aceclofenac cannot be reduced less than 14 microns then at the time of Permeation studies the same particle size will enter in Stratum corneum of Skin and entrapped in the carrier matrix. And formation of microns sized particles will obtained while preparing Solid lipid nanoparticles. Keywords: Solubilization, Particle size reduction, Air jet mill, high shear homogenizer, particle size analyzer, Dynomil