Geometric discord and Measurement-induced nonlocality for well known bound entangled states

We employ geometric discord and measurement induced nonlocality to quantify non classical correlations of some well-known bipartite bound entangled states, namely the two families of Horodecki's ($2\otimes 4$, $3\otimes 3$ and $4\otimes 4$ dimensional) bound entangled states and that of Bennett etal's in $3\otimes 3$ dimension. In most of the cases our results are analytic and both the measures attain relatively small value. The amount of quantumness in the $4\otimes 4$ bound entangled state of Benatti etal and the $2\otimes 8$ state having the same matrix representation (in computational basis) is same. Coincidently, the $2m\otimes 2m$ Werner and isotropic states also exhibit the same property, when seen as $2\otimes 2m^2$ dimensional states.Comment: V2: Title changed, one more state added; 11 pages (single column), 2 figures, accepted in Quantum Information Processin

Fluctuation relations for heat engines in time-periodic steady states

A fluctuation relation for heat engines (FRHE) has been derived recently. In the beginning, the system is in contact with the cooler bath. The system is then coupled to the hotter bath and external parameters are changed cyclically, eventually bringing the system back to its initial state, once the coupling with the hot bath is switched off. In this work, we lift the condition of initial thermal equilibrium and derive a new fluctuation relation for the central system (heat engine) being in a time-periodic steady state (TPSS). Carnot's inequality for classical thermodynamics follows as a direct consequence of this fluctuation theorem even in TPSS. For the special cases of the absence of hot bath and no extraction of work, we obtain the integral fluctuation theorem for total entropy and the generalized exchange fluctuation theorem, respectively. Recently microsized heat engines have been realized experimentally in the TPSS. We numerically simulate the same model and verify our proposed theorems.Comment: 9 page

Primary cerebral angitis of the central nervous system: case report

We report a case of a 28 year old female who presented with variedly progressive stroke like illness and raised intracranial pressure. Brain MRI scans revealed pericallosal and periventricular hyperintensities with oedema. Various medications like intravenous immunoglobulin, antibiotics, acyclovir, methyl prednisolone and management for raised intracranial pressure were instituted. She rapidly deteroriated and died on tenth hospital day. Only at autopsy was the diagnosis of primary angitis of central nervous system established

Cancer of the penis: case report

Two patients with penile carcinoma are presented after management at a district hospital in Kenya. Both had undergone ritual circumcision as teenagers and presented late. HR was a 73 year old who presented with a fungating penile mass for which a partial penectomy was performed after wedge biopsy confirmed malignancy. He thereafter declined to have the surgical specimen sent for histology and took the amputated stump for burial in his compound to avoid bad omen. GK was 25 years old and presented with a fungating mass and underwent partial penectomy after a histological diagnosis was made. He absconded from follow-up after being informed of the need for further surgery due to tumour infiltration of the surgical margins. The history and clinical images are presented and we discuss the difficulties of cancer management at a rural district hospital

Strong lensing systems and galaxy cluster observations as probe to the cosmic distance duality relation

In this paper, we use large scale structure observations to test the cosmic distance duality relation (CDDR), $D_{\rm L}(1+z)^{-2}/D_{\rm A}=\eta=1$, with $D_{\rm L}$ and $D_{\rm A}$, being the luminosity and angular diameter distances, respectively. In order to perform the test, the following data set are considered: strong lensing systems and galaxy cluster measurements (gas mass fractions). No specific cosmological model is adopted, only a flat universe is assumed. By considering two $\eta(z)$ parametrizations, we obtained the validity of the CDDR within $1.5\sigma$ which is in full agreement with other recent tests involving cosmological data. It is worth to comment that our results are independent of the baryon budget of galaxy clusters.Comment: 6 pages, two figs, one tabl

Detection of Type 2 Diabetes Mellitus in Serum from Women with Polycystic Ovarian Syndrome

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder. To determine the metabolic disorders in women with PCOS, (25) women with PCOS ages (15 - 47) years have been investigated and compared with (20) healthy individuals. All the studied groups were carried out to measure fasting blood sugar, (anti-GAD Ab, anti ?-islet cell Ab by IFAT) and measured insulin level by ELISA. There was significant elevation in the concentration of fasting blood sugar than in control groups (p ? 0.05) and there was negative results for anti-GAD Ab and anti ?-islet cell Ab by IFAT test for serum of women with PCOS, while there was significant differences in the insulin level for women with PCOS compared with control groups (p ? 0.05), these indicated that women with PCOS are at high risk for type -2 Diabetes mellitus and reflecting insulin resistance

Biosensing platform combining label-free and labelled analysis using Bloch surface waves

Bloch surface waves (BSW) propagating at the boundary of truncated photonic crystals (1D-PC) have emerged as an attractive approach for label-free sensing in plasmon-like sensor configurations. Due to the very low losses in such dielectric thin film stacks, BSW feature very low angular resonance widths compared to the surface plasmon resonance (SPR) case. Besides label-free operation, the large field enhancement and the absence of quenching allow utilizing BSW coupled fluorescence detection to additionally sense the presence of fluorescent labels. This approach can be adapted to the case of angularly resolved resonance detection, thus giving rise to a combined label-free / labelled biosensor platform. It features a parallel analysis of multiple spots arranged as a one-dimensional array inside a microfluidic channel of a disposable chip. Application of such a combined biosensing approach to the detection of the Angiopoietin-2 cancer biomarker in buffer solutions is reported

Cheilitis glandularis progressing to squamous cell carcinoma in an HIV-infected patient: case report

Cheilitis glandularis (CG), is a rare inflammatory minor salivary gland disease affecting the lower lip.The hallmarks of which include progressive enlargement and eversion of the lower labial mucosa resulting in the obliteration of the mucosal vermillion interface. A case is presented of a 47-year-old HIV-infected woman who initially manifested clinical features of CG with a typical histopathology picture of a non-specific sialadenitis while a second biopsy performed six months later revealed well differentiated squamous cell carcinoma (SCC). She is symptom free one year following excision and radiotherapy treatment

Subtle pH differences trigger single residue motions for moderating conformations of calmodulin

This study reveals the essence of ligand recognition mechanisms by which calmodulin (CaM) controls a variety of Ca2+ signaling processes. We study eight forms of calcium-loaded CaM each with distinct conformational states. Reducing the structure to two degrees of freedom conveniently describes main features of the conformational changes of CaM via simultaneous twist-bend motions of the two lobes. We utilize perturbation-response scanning (PRS) technique, coupled with molecular dynamics simulations. PRS is based on linear response theory, comprising sequential application of directed forces on selected residues followed by recording the resulting protein coordinates. We analyze directional preferences of the perturbations and resulting conformational changes. Manipulation of a single residue reproduces the structural change more effectively than that of single/pairs/triplets of collective modes of motion. Our findings also give information on how the flexible linker acts as a transducer of binding information to distant parts of the protein. Furthermore, by perturbing residue E31 located in one of the EF hand motifs in a specific direction, it is possible to induce conformational change relevant to five target structures. Independently, using four different pKa calculation strategies, we find this particular residue to be the charged residue (out of a total of 52), whose ionization state is most sensitive to subtle pH variations in the physiological range. It is plausible that at relatively low pH, CaM structure is less flexible. By gaining charged states at specific sites at a pH value around 7, such as E31 found in the present study, local conformational changes in the protein will lead to shifts in the energy landscape, paving the way to other conformational states. These findings are in accordance with Fluorescence Resonance Energy Transfer (FRET) measured shifts in conformational distributions towards more compact forms with decreased pH. They also corroborate mutational studies and proteolysis results which point to the significant role of E31 in CaM dynamics