Pre-fire (1985) and post-fire (2010) cumulative distributions.

<p>Pre-fire (1985) and post-fire (2010) cumulative distributions of NBR values from different fire pairs. a. 1999 Pine fire and 2006 Esperanza fire b. 2003 Cedar fire and 2007 Witch fire. c. 1996 Highway58 fire and 2003 Parkhill fire.</p

The effect of EPO on the expression of inflammatory signaling events in the liver.

<p>The levels of activated NF-<i>κ</i>B p65 in the liver were determined by DNA binding-based ELISA (<b>A</b>). The relative levels of TLR4 expression were characterized by RT-PCR (<b>B</b>) and Western blot assays (<b>C</b>). The relative levels of JNK (<b>D</b>), ERK (<b>E</b>) and p38 MAPK (<b>F</b>) phosphorylation in the liver were characterized by Western blot assay and densimetric analysis. Data are representative images or expressed as the mean ± SEM of each group (n = 6) of mice from three separate experiments. ^#P<0.05 vs. the NC group, *P<0.05 vs. the HFD-Con group.</p

The effect of EPO on HFD-fed mice.

<p>C57BL/6 mice were fed with HFD for 12 weeks and treated with EPO (HFD-EPO) or injected with saline (HFD-Con) for two weeks. A control group (NC) of mice was fed with normal chow and injected with saline. The body weights and amounts of food consumed in individual mice were measured at the indicated time points. At the end of treatment, the mice were fasted and subjected to measurements of the levels of fasting blood glucose, fasting serum insulin and IPGTT. The AUC for blood glucose in individual mice was calculated. Data are present as the mean ± SEM of each group (n = 8) of mice from two-three separate experiments. (<b>A</b>) The body weights. (<b>B</b>) The levels of fasting blood glucose. (<b>C</b>) The levels of fasting serum insulin. (<b>D</b>) The glucose tolerance. (<b>E</b>) The values of AUC. There was no significant difference in the amounts of food intake among these groups of mice (data not shown). ^#P<0.05 or ^##P<0.01 vs. the NC group, *P<0.05 or **P<0.01 vs. the HFD-Con group.</p

The sequences of the primers.

<p>The sequences of the primers.</p

Fire areas and 1985 and 2010 Landsat images.

<p>Landsat-5 TM images covering areas burned by the Cedar fire in 2003 and the Witch fire in 2007. a. 1985 Landsat-5 TM, bands 5, 4, and 3 displayed as red, green, and blue, respectively. b. 2010 Landsat-5 TM, bands 5, 4, and 3 displayed as red, green, and blue, respectively.</p

The effect of EPO on the levels of insulin signaling events in the liver.

<p>The levels of total Akt, IR and IRS1 and phosphorylated Akt, IR and IRS1 in the livers of individual mice were determined by Western blot assays and the relative levels of Akt, IR and IRS1 phosphorylation were analyzed by densimetric analysis using ImageJ software. Data shown are representative images and expressed as the mean ± SEM of individual groups (n = 6 per group) of mice from three separate experiments. (<b>A</b>) Western blot and quantitative analyses of the levels of Akt activation. (<b>B</b>) Western blot and quantitative analyses of the levels of IR activation. (<b>C</b>) Western blot and quantitative analyses of the levels of IRS1 activation. *P<0.05 vs. the HFD-Con group.</p

Explanatory variables used in simple linear regression analysis.

<p>Explanatory variables used in simple linear regression analysis.</p

Dates and estimated cloud cover for each Landsat image used in the study.

<p>Dates and estimated cloud cover for each Landsat image used in the study.</p

Descriptions of indices used in this study.

<p>Descriptions of indices used in this study.</p

Comparison of results for fire pairs with similar cumulative distributions of 1985 NBR values^a.

<p>ID number refers to fire pairs shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110637#pone-0110637-g001" target="_blank">Figure 1</a>.</p>a<p>Sorted by decreasing change in DMN.</p><p>Comparison of results for fire pairs with similar cumulative distributions of 1985 NBR values^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110637#nt102" target="_blank">a</a>}.</p