Caledonian and Knoydartian overprinting of a Grenvillian inlier and the enclosing Morar Group rocks: structural evolution of the Precambrian Proto-Moine Nappe, Glenelg, NW Scotland

The Grenville and Caledonian orogens, fundamental to building Laurentia and Baltica, intersect in northern Scotland. The Precambrian Glenelg Inlier, within the Scottish Caledonides, preserves a record of Grenvillian, Knoydartian and Caledonian orogenesis. Based on new mapping and re-interpretation of previous mapping, we present a structural model for the evolution of the Glenelg Inlier. The inlier can be divided into Western Glenelg gneiss comprising orthogneiss with no record of Grenville-age metamorphism, and Eastern Glenelg gneiss with ortho- and paragneiss, affected by Grenvillian eclogite-facies metamorphism. The basement gneisses and their original cover of psammitic, Neoproterozoic Morar Group (Moine) rocks were deformed by three generations of major ductile folds (F1–F3). In medium-strain areas F2 and F3 folds are broadly coaxial and both face to the west; in higher strain areas F2 and F3 folds are oblique to each other. By restoring post-F1 folds and late faults, the Glenelg gneiss inliers are seen to form the core of a major recumbent SSE-facing F1 isoclinal fold nappe – the Proto-Moine Nappe. The upper limb of this nappe is a thick, right-way-up sequence of moderately strained Morar Group rocks whereas the lower, inverted limb comprises intensely deformed, migmatitic Morar Group rocks. Within the constraints of published geochronology, the Proto-Moine Nappe is likely Pre-Caledonian and may have originated during the early Neoproterozoic Knoydartian Orogeny

Chronic lymphocytic leukaemia: the role of T cells in a B cell disease

Chronic lymphocytic leukaemia (CLL) has long been thought to be an immunosuppressive disease and abnormalities in T‐cell subset distribution and function have been observed in many studies. However, the role of T cells (if any) in disease progression remains unclear and has not been directly studied. This has changed with the advent of new therapies, such as chimeric antigen receptor‐T cells, which actively use retargeted patient‐derived T cells as “living drugs” for CLL. However complete responses are relatively low (~26%) and recent studies have suggested the differentiation status of patient T cells before therapy may influence efficacy. Non‐chemotherapeutic drugs, such as idelalisib and ibrutinib, also have an impact on T cell populations in CLL patients. This review will highlight what is known about T cells in CLL during disease progression and after treatment, and discuss the prospects of using T cells as predictive biomarkers for immune status and response to therapy

Technology and Discourse: A Comparison of Face-to-face and Telephone Employment Interviews

Very little research has investigated the comparability of telephone and face-to-face employment interviews. This exploratory study investigated interviewers' questioning strategies and applicants' causal attributions produced during semi structured telephone and face-to-face graduate recruitment interviews (N=62). A total of 2044 causal attributions were extracted from verbatim transcripts of these 62 interviews. It was predicted that an absence of visual cues would lead applicants to produce, and interviewers to focus on, information that might reduce the comparative anonymity of telephone interviews. Results indicate that applicants produce more personal causal attributions in telephone interviews. Personal attributions are also associated with higher ratings in telephone, but not face-to-face interviews. In face-to-face interviews, applicants who attributed outcomes to more global causes received lower ratings. There was also a non-significant tendency for interviewers to ask more closed questions in telephone interviews. The implications of these findings for research and practice are discussed

Non-melanoma skin cancer risk in the Queensland renal transplant population

Background Non-melanoma skin cancer (NMSC) is an important complication of solid organ transplantation, especially in areas of high ultraviolet light exposure. Registry data may underestimate the scale of the problem

Ancient orphan crop joins modern era: Gene-based SNP discovery and mapping in lentil

Background: The genus Lens comprises a range of closely related species within the galegoid clade of the Papilionoideae family. The clade includes other important crops (e.g. chickpea and pea) as well as a sequenced model legume (Medicago truncatula). Lentil is a global food crop increasing in importance in the Indian sub-continent and elsewhere due to its nutritional value and quick cooking time. Despite this importance there has been a dearth of genetic and genomic resources for the crop and this has limited the application of marker-assisted selection strategies in breeding.Results: We describe here the development of a deep and diverse transcriptome resource for lentil using next generation sequencing technology. The generation of data in multiple cultivated (L. culinaris) and wild (L. ervoides) genotypes together with the utilization of a bioinformatics workflow enabled the identification of a large collection of SNPs and the subsequent development of a genotyping platform that was used to establish the first comprehensive genetic map of the L. culinaris genome. Extensive collinearity with M. truncatula was evident on the basis of sequence homology between mapped markers and the model genome and large translocations and inversions relative to M. truncatula were identified. An estimate for the time divergence of L. culinaris from L. ervoides and of both from M. truncatula was also calculated.Conclusions: The availability of the genomic and derived molecular marker resources presented here will help change lentil breeding strategies and lead to increased genetic gain in the future. \ua9 2013 Sharpe et al.; licensee BioMed Central Ltd.Peer reviewed: YesNRC publication: Ye