Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with Prader-Willi Syndrome - Fig 3

<p><b>Postprandial BDNF (Brain-derived neurotrophic factor) (A) and leptin (B) levels in subjects with Prader-Willi syndrome (PWS), in obese controls, and in lean controls.</b> A peak in BDNF at 60 min was observed only in lean subjects (p<0.05 baseline vs 60 min in lean controls). Subjects with PWS had lower BDNF levels at 60 and 120 min than lean controls (p<0.05). Leptin levels within groups did not change between baseline and postprandial measurements. PWS subjects had higher leptin levels than the other groups at all time points (p<0.001).</p

Baseline characteristics of all groups.

<p>Baseline characteristics of all groups.</p

Plasma Brain-derived neurotrophic factor (BDNF) levels in subjects with Prader-Willi syndrome (PWS) and in obese and lean control subjects.

<p>PWS subjects vs. obese and lean controls, P = 0.05.</p

Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with Prader-Willi Syndrome - Fig 4

<p><b>Fasting and postprandial plasma Brain-derived neurotrophic factor (BDNF) (A) and leptin (B) levels (circles) in the three groups, overlaid with hunger score (stars) over time.</b> Note that postprandial BDNF peak in lean controls coincides with the lowest hunger score. PWS = Prader Willi Syndrome. Hunger was quantified on a visual analogue scale ranging from 0 to 100.</p

Hunger score at fasting (circles) versus 60’ after the meal (stars) in the different genetic subtypes of Prader-Willi syndrome subjects.

<p>P = 0.034 for uniparental disomy, nonsignificant for the rest. Hunger was quantified on a visual analogue scale from 0 to 100.</p