Relationship between Glycated Hemoglobin Levels and the Iodine uptake in Patients with Diabetes Mellitus

ABSTRACT Iodination is the process of substitution or addition of iodine atoms on organic compounds. The iodine is reactive with all the three major biochemical constituents namely proteins, lipids and carbohydrates. Present study was done to know the relationship between iodine uptake and glycated hemoglobin (GlyHb) levels in patients with diabetes mellitus.The study was carried out in 50 patients with diabetes mellitus with mean GlyHb of 10.4±2 gm% and 25 healthy controls with mean GlyHb level of 5.5±0.5 gm%.The modified version of the colorimetric method was employed for the assay of iodine uptake and Glyco Hb levels were measured by 501 auto analyzer. The data was analyzed using SPSS version 10. Serum total iodine uptake was decreased significantly (p<0.001) in the patients with diabetes mellitus compared to healthy controls. There was significant negative correlation (r= -0.942, p<0.01) between glyHb and iodine uptake in diabetes mellitus patients. We found significant decrease in iodine uptake in diabetes patients compared as to controls. This may be due to increased glycation of proteins induced by hyperglycemia which may interfere in binding of iodine to proteins including hemoglobin. Significant negative correlation between glyHb and iodine uptake can be due to decrease in the availability of iodine binding sites due to alteration in the structure of proteins, which is possibly induced by glycation of proteins, associated with diabetes mellitus. According to our study iodine uptake is decreased in patients with diabetes mellitus which may be due to increased glycation of proteins