Cefepime-Enmetazobactam: a novel β-Lactam/β-Lactamase inhibitor combination for complicated urinary tract infections

Complicated urinary tract infections (cUTIs) represent a significant global health challenge, particularly with the rising prevalence of extended-spectrum β-lactamase (ESBL)-producing pathogens. Cefepime-Enmetazobactam, approved in India in June 2024, represents a novel β-lactam/β-lactamase inhibitor combination specifically developed to address multidrug-resistant Gram-negative infections. This review examines the pharmacological properties, clinical efficacy, and therapeutic potential of Cefepime-Enmetazobactam in managing cUTIs. The Phase 3 ALLIUM trial demonstrated superior clinical cure and microbiological eradication rates compared to Piperacillin-Tazobactam, with particularly pronounced efficacy against ESBL-producing Enterobacterales (73.7% vs 51.5%). The combination exhibits a favourable safety profile with transaminase elevation, increased bilirubin, headache, and infusion site reactions being the most common adverse events. As a carbapenem-sparing option, Cefepime-Enmetazobactam addresses critical antimicrobial stewardship concerns while providing an effective treatment alternative for resistant pathogens. While demonstrating promising results, further research regarding long-term outcomes, resistance development, and cost-effectiveness is warranted to fully establish its role in contemporary antimicrobial therapy

Double Trouble: A Rare Association between Chronic Total Occlusion of the Left Main Coronary Artery and Colonic Malignancy

AbstractEmerging evidence has shown an association between cardiovascular (CV) disease and cancer due to shared risk factors and biological mechanisms especially chronic inflammation. The objective of this case report is to highlight the association between these two lethal diseases and the challenges in the management of coronary artery disease in patients with coexisting malignancy.A 65-year-old nonsmoker, nondiabetic, and normotensive male presented with a history of abdominal pain and significant weight loss. Colonoscopy and biopsy showed adenocarcinoma of the ascending colon, and he was planned for right hemicolectomy. Electrocardiogram exercise stress test performed as a part of preoperative evaluation was strongly positive. Coronary angiography was suggestive of Chronic total occlusion of the left main coronary artery. Though the syntax score was intermediate, coronary artery bypass grafting was decided as the revascularization strategy as he needed early surgery for the colonic malignancy. A month later, he underwent right hemicolectomy.Clinicians should be aware of the association between CV disease and cancer as they are likely to face similar situations where both coexist. Understanding the connections between heart disease and cancer will help to formulate combined preventive guidelines.</jats:p

Inorganic Adsorption on Thermal Response and Wear Properties of Nanosilicon Nitride-Developed AA6061 Alloy Nanocomposite

Inorganic-based ceramic reinforcements are promising superior thermal behaviour and are lightweight and developed with aluminium alloy matrix for automobile applications. The AA6061 alloy nanocomposite containing 0 wt%, 4 wt%, 8 wt%, and 12 wt% of silicon nitride nanoparticles(50 nm) was synthesized by stir cast. The influences of thermal adsorption on silicon nitride (nano) additions, density, thermal response, hardness, and wear characteristics of AA6061 matrix nanocomposites are studied. Based on the rule of mixture, the density of nanocomposites is evaluated. The differential thermal and thermogravimetric analysis techniques are used to find the thermal response nanocomposite. The differential scanning calorimeter is used to find the heat flow between 400°C and 700°C. The micro Vickers hardness and wear characteristics of AA6061 nanocomposite were experimentally investigated by ASTM E384 and ASTM G99-05 standards. The adsorption of inorganic nanosilicon nitride particles (12 wt%) in AA6061 alloy showed a decreased mass loss with increased temperatures 0° to 700°C. The differential thermal analysis of nanocomposite reveals the transformation of solid-to-liquid phase under high temperature (528°C)

Inorganic Adsorption on Thermal Response and Wear Properties of Nanosilicon Nitride-Developed AA6061 Alloy Nanocomposite

Inorganic-based ceramic reinforcements are promising superior thermal behaviour and are lightweight and developed with aluminium alloy matrix for automobile applications. The AA6061 alloy nanocomposite containing 0 wt%, 4 wt%, 8 wt%, and 12 wt% of silicon nitride nanoparticles(50 nm) was synthesized by stir cast. The influences of thermal adsorption on silicon nitride (nano) additions, density, thermal response, hardness, and wear characteristics of AA6061 matrix nanocomposites are studied. Based on the rule of mixture, the density of nanocomposites is evaluated. The differential thermal and thermogravimetric analysis techniques are used to find the thermal response nanocomposite. The differential scanning calorimeter is used to find the heat flow between 400°C and 700°C. The micro Vickers hardness and wear characteristics of AA6061 nanocomposite were experimentally investigated by ASTM E384 and ASTM G99-05 standards. The adsorption of inorganic nanosilicon nitride particles (12 wt%) in AA6061 alloy showed a decreased mass loss with increased temperatures 0° to 700°C. The differential thermal analysis of nanocomposite reveals the transformation of solid-to-liquid phase under high temperature (528°C).</jats:p