TGA studies of metoclopramide complexes of cobalt(II) in the solid state

A new series of cobalt(II) complexes with metoclopramide (MCP) ligand have been prepared. The prepared Co(II)-MCP complexes were characterized for various analytical techniques. Conductivity and elemental analysis of complexes have been measured. The thermal stability and degradation kinetics have been measured using thermogravimetric analyser. Kinetic parameter was obtained for each stage of thermal degradation for Co(II)-MCP complexes using Horowitz-Metzger, Coats-Redfern and Broido's methods. The activation energy (Ea) of the complexes for the thermal degradation process lie in the range 31-168, 23-161 and 33-170 kJ mol-1 for Horowitz-Metzger, Coats-Redfern and Broido's methods, respectively. © 2003 Elsevier B.V. All rights reserved

Thermoanalytical and spectral characterization of cadmium(II) complexes of propantheline bromide

Synthesis, structure and properties of Cd(II) complexes of propantheline bromide (PPB) have been studied. The isolated complexes are characterised by various physico-chemical methods. Based on the data, tetrahedral structure has been suggested for the new metal complexes. Thermogravimetric studies of the complexes have Seen performed in order to establish the mode of their thermal stability. The thermal degradation process was found to proceed in two steps. Kinetic and thermodynamic parameters are evaluated on the basis of thermal degradation data. The values of activation energies are found to be in the range 8.5-33.5 kJ mol(-1)

Structural and Antimicrobial Studies of Some Newly Synthesised Complexes of Cobalt (II) of Bioinorganic Relevance

Five new complexes of cobalt(II) have been synthesised by the interaction of fluphenazine (FPH) with cobalt(II) chloride, bromide, perchlorate, acetate or sulphate. The complexes which have been found to possess a stoichiometric composition of Co(C22H26F3N3OS)(H2O)(2)X(2)] have been characterised for their purity with the help of elemental studies, conductivity and magnetic measurements. An octahedral structure has been proposed based on thermal, electronic and IR spectral data. The new complexes-have been tested in vitro for their antimicrobial activity against Alternaria alternata, Aspergillus flavus, Escherichia coli and Staphylococcus aureus. The antibacterial activity of the cobalt(II) complexes against E. coli and S. aureus increases in the order: sulphate > chloride > perchlorate

Synthesis, spectral, thermal studies and antimicrobial activity of cobalt(II) complexes of propantheline bromide

The synthesis, spectral characterization, magnetic, susceptibility and molar conductance studies of new series of cobalt(II)complexes of propantheline bromide (PPB) with general stoichiometry Co(PPB)(2)(H2O)(2)X(2)] are reported, where X = Cl-, Br-, ClO4- and CH3COO-. In all the complexes PPB behaves as a unidentate ligand. Thermal studies (TG/DTA) have been used to evaluate kinetic parameters such as order of the thermal reaction (n) and activation energy (E(a)). These new complexes were found to be more potent as antimicrobial agents than the free ligand

Kinetic and thermal stability of cobalt(II)-imipramine complexes

New six cobalt(II)-imipramine complexes have been thermally explored in great detail to evaluate the kinetic and thermodynamic parameters such as activation energy I,, preexponential factor In A, enthalpy Delta H, free energy Delta G and entropy Delta S. The enthalpy values and activation energy values are in the range 2.90-139.22 kJ mol(-1) and 6.54-9.95 W mol(-1), respectively

Synthesis, Characterization and Antimicrobial Activity of Palladium(Ii) Complexes of Diphenylpyraline and Isothipendyl

Two complexes of palladium with diphenylpyraline (DPH) and isothipendyl (IPH) of the formulae Pd(DPH)2Cl2] and Pd(IPH)Cl2] have been synthesised and characterized by elemental analysis, IR, NMR, electronic, magnetic susceptibility, TGA and XRD data. The IR data suggests that while DPH acts as monodentate ligand, IPH acts as bidentate ligand. On the basis of spectral data, a square planar structure is proposed. These complexes are found to be more potent as antibacterial and antifungal agents that the free ligands

Biologically active metal complexes with phenothiazines and related ligands: a review

The review mainly deals with the analytical, biological and structural aspects of the biologically active metal complexes with phenothiazines and related ligands. The work described primarily belongs to the author's and his associates

Spectrophotometric method for the determination of ritodrine hydrochloride and amoxicillin

A rapid and sensitive spectrophotometric method is described for the determination of ritodrine hydrochloride (RTH) and amoxicillin (AMX) in both pure and dosage forms. The proposed method uses 3-methyl benzothiazolin-2-one hydrazone as a chromogenic reagent. A mixture of aqueous solutions of the drug and reagent is treated with ammonium cerium(IV) sulfate in an acidic medium to yield pink-colored species. These species exhibit maximum absorption at 520 nm for RTH and at 490 nm for AMX with a molar absorptivity of 2.35x10(4) and 1.27x10(4) l mol(-1) cm(-1) for Pim and AMX, respectively. The optimum reaction conditions and other analytical parameters are evaluated. The influence of the substrates commonly employed as excipients with these drugs have been studied. The proposed method was applied to the determination of these drugs in pharmaceutical formulations. The results have demonstrated that the method is equally accurate and reproducible as the official methods

Extraction-Spectrophotometric Determination of Bismuth(Iii) in Woods Alloy Through Complexation of Hexa-Iodobismuthate and Prochlorperazine Mesylate

A new modified spectrophotometric method for the determination of trace quantities of bismuth has been developed based on the complexation between prochlorperazine mesylate and hexaiodobismuthate. The orange red complex, which is stable for 48 h has an absorption maxima at 485 nm with a molar absorptivity df 3.53 x 10(3) L per mol per cm and Sandall's sensitivity 0.16 mu g cm(-2). Calibration graph is rectilinear for 0.6 to 18 ppm of bismuth. Effect of time, temperature, reagent concentration and order of addition of reagents have been studied. The proposed method had been used for the determination of bismuth in Wood's alloy as it offers the advantages of simplicity, rapidity and accurate procedure