A New Modified Collection Selection Algorithm using Optimal Term Weight for Web based Applications

As the number of electronic data collections available on the internet increases so does the difficulty of finding the right collection for a given query Often the first time user will be overwhelmed by the array of options available and will waste time hunting through pages of collection names followed by time reading results pages after doing an adhoc search Collection selection using optimal weight methods try to solve this problem by suggesting the best subset of collections to search based on a query This is of importance to fields containing large number of electronic collections which undergo frequent change and collections that cannot be fully indexed using traditional methods such as spiders This paper presents a solution to these problems of selecting the best collections and reducing the number of collections needing to be searche

PROCESS AND PARAMETERS AFFECTING DRUG RELEASE PERFORMANCE OF PREPARED CROSS-LINKED ALGINATE HYDROGEL BEADS FOR EZETIMIBE

Objective: The objective of this study was to formulate an oral sustained release delivery system of ezetimibe mucoadhesive beads by ionic gelation technique based on sodium alginate used as a hydrophilic carrier in combination with carbopol 934P which acts as a rate modifier.Methods: Microbeads of ezetimibe were prepared using an easy method of ionotropic gelation by little modification while in addition of drug. The prepared beads were characterised for mean particle size, entrapment efficiency, swelling capacity, and in vitro release. They were also subjected to various studies such as Fourier Transform Infrared Spectrophotometer (FTIR) Spectroscopy for drug polymer reaction, Scanning Electron Microscopy for surface morphology, and Differential Scanning Calorimetric Analysis to determine the physical state of the drug in the beads.Results: The microspheres of ezetimibe were formulated successfully. The addition of drug concentration gives higher drug loading and higher conc. of Alcl+3 yields small diameter beads and lower drug entrapment. Analysis of the release profiles showed that the data corresponds to zero order release and the diffusion-controlled mechanism as suggested by Higuchi concept.Conclusion: It can be concluded that beads produced by the sequential method had higher drug entrapment. Beads produced by simultaneous yields larger beads in diameter. The concept was cleared that drug release was dependent upon the quantity of polymer and increase in conc. of. aluminium chloride retarded the drug release in the sequential method. Prepared beads enhance the dissolution of ezetimibe and the oral bioavailability and also reduce the fluctuations in the oral bioavailability

INSIGHT OF METHANOLIC EXTRACT OF VENTILAGO MADERASPATANA LEAVES ON HEPATOPROTECTIVE ACTIVITY UNDER STREPTOZOTOCIN-INDUCED DIABETIC RATS

Objective: The methanolic leaf extract of Ventilago maderaspatana (MEVML, 200 mg/kg body weight [b.w.]) was investigate to hepatoprotective activity under streptozotocin-induced (45 mg/kg b.w.) diabetic (Di) rats. Methods: In the present study, we determined the blood glucose levels, b.w., insulin, creatinine, and bilirubin levels in normal, Di, Di treated with MEVML and positive control rats. Results: The Di rats shown adverse changes in blood glucose levels, b.w., insulin, creatinine, and bilirubin levels when compared to other group rats. Reverse the adverse changes in the above parameters when treated the Di rats with MEVML Conclusion: The MEVML shown anti-diabetic activity and reverse the adverse changes in the above parameters in liver so that the MEVML supported the traditional claim of the hepatoprotective activity under Di condition

Improvement of Voltage Profile through the Optimal Placement of FACTS Using L-Index Method

In this paper an IEEE standard test system is considered and it is tested using Newton-Raphson method with the help of MATLAB. The voltage magnitudes of each bus are examined and the corresponding weak bus is incorporated with FACTS such as SVC and TCSC. The optimal placement of FACTS can be identified using L-Index method. The value of L-index which approach unity implies that it reaches to instability. From this instability point the system stability is improved during steady state and Fault conditions. The disturbance is created in the system by changing the Load Reactive Power at a particular Bus.DOI:http://dx.doi.org/10.11591/ijece.v4i2.513

ELEVATING THE PROBLEMS OF LINEAR SEARCHABLE CIPHERTEXT ON LARGE-SCALE DATABASE

The thought of traditional public-key file encryption by keyword search does not hold any hidden structure involving the public-key file encryption by keyword search cipher-texts correspondingly, its semantic security is just defined for your keywords and phrases. We are concerned in provision of efficient search performance missing of compromising semantic security within public-key file encryption by keyword search. Inside our work we introduce searchable public-key cipher-texts by hidden structures for keyword search as rapidly as achievable missing of compromising semantic security regarding encoded keywords and phrases. Our structure is inspired by a lot of interesting findings using the systems of on Identity-Based Key Encapsulation. Inside the recommended system, the entire keyword-searchable cipher-texts that are structured by hidden relations, by search trapdoor that suits a keyword, minimum data of relations is revealed with a search formula as management to locate the whole matching cipher-texts resourcefully

DEVELOPMENT AND CHARACTERIZATION OF GASTRO RETENTIVE MUCOADHESIVE MICROBEADS CONTAINING SIMVASTATIN WITH DIFFERENT CROSS LINKING AGENTS

Objective: The aim of the present work was to prepare and examine drug release of the oral controlled release microbeads using different curing agents by emulsification internal ionic gelation technique. Methods: Cross-linked alginate microbeads were prepared with different cross linking agents by using mucoadhesive properties. The formation and compatibility of microbeads were confirmed by compatibility studies. Prepared microbeads evaluated for encapsulated efficiency, micromeritic properties, drug loading, in vitro wash off studies, in vitro dissolution studies, drug release kinetics and stability studies Results: The in vitro drug release was influenced by both type of curing agents and type of polymers and no significant changes in characterization parameters was observed after 3 mo stability studies. The sustained release profile of optimized batch was found to be 99.66±0.18% in comparison to pure drug profile of 28.64±0.02% at 12 h release study. Results of both wash-off and in vitro studies suggests that batch (SF2) prepared with aluminium chloride has shown better mucoadhesive property. Drug release of optimized batch follows zero order with non fickian mechanism according to Korsmeyer-Peppas equation. Conclusion: The data suggest the use of simvastatin mucoadhesive cross linked microbeads to offer the potential for oral controlled drug delivery with improved gastric retention and capable to provide sustained drug release by using cross linking agents

Experimental Evidence of Time Delay Induced Death in Coupled Limit Cycle Oscillators

Experimental observations of time delay induced amplitude death in a pair of coupled nonlinear electronic circuits that are individually capable of exhibiting limit cycle oscillations are described. In particular, the existence of multiply connected death islands in the parameter space of the coupling strength and the time delay parameter for coupled identical oscillators is established. The existence of such regions was predicted earlier on theoretical grounds in [Phys. Rev. Lett. 80, 5109 (1998); Physica 129D, 15 (1999)]. The experiments also reveal the occurrence of multiple frequency states, frequency suppression of oscillations with increased time delay and the onset of both in-phase and anti-phase collective oscillations.Comment: 4 aps formatted RevTeX pages; 6 figures; to appear in Phys. Rev. Let

Alginate Microspheres: The Innovative Approaches to Production of the Microbeads/Micro-Particles

Multiparticulate dosage form is pharmaceutical formulations where the active substance is in the form of a number of small independent subunit such as, granules, microparticle, beads, and microspheres. Multiparticulate drug delivery systems are specifically suitable for achieving delayed and sustained release oral formulations with a minimum risk of dose dumping, local irritation, systemic toxicity, and variation in rate of bioavailability as they are less dependent on gastrointestinal transit time and offers many advantages over unit particulate dosage forms. Microbeads are small, sphere shaped, systematically produced free-flowing properties, semi-spherical solid units. Microbeads are the agglomerates of about size ranging from 0.5 mm to 1.0 mm, obtained from various starting materials and utilizing different innovative techniques. A blend of multiparticulate can also be used to provide the desired drug release profile. These round shaped particles produced by mostly principle of atomization technique.Among various different innovative techniques Vibration technology, Electrostatic bead generator, Jetcutter technology, electrostatic forces, dropping method and a mechanical cutting device are few of many. In current article it describes about the total methods involved and their working principles with diagrams were clearly illustrated. Now a days sodium alginate beads were designed by these technologies mostly in relative to microencapsulation techniques. Keywords: Atomization, Vibrating technology, Jetcutter device, Electrostatic bead generator Dropping method and electro-spray technolog