Pulsatile flow of a viscous fluid in elliptical pipe of variable cross-section

The pulsatile flow of an incompressible viscous fluid in an elliptical pipe of slowly varying cross-section is considered. Asymptotic series solutions for the velocity distribution and pressure gradient are obtained in terms of Mathieu functions for a low Reynold number flow in which the volume flux is prescribed. An expression for shear stress on the boundary is derived. The physically significant quantities governing the flow are computed numerically and analysed for different types of constrictions. The effect of eccentricity and Womerslay parameter on the flow is discussed

Synthesis of a new class of bis heterocycles

1295-1300A variety of bis heterocycles-oxazolyl / thiazolyl / imidazolyl pyrroles and pyrazoles have been prepared adopting 1,3-dipolar cycloaddition of tosylmethyl isocyanide and diazomethane to oxazolyl / thiazolyl / imidazolyl acrylamides

A MOLECULAR DOCKING AND HIGH THROUGHPUT SCREENING OF POTENT SMALL INHIBITOR TO NLRP3 IN TUBERCULOSIS THROUGH DRUG DESIGNING STUDIES

ABSTRACT Tuberculosis disease caused by Mycobacterium tuberculosis (Mtb) and one of the major bacterial infections in the worldwide. Host defense against Mtb is mediated by a combination of innate and adaptive immune responses. Toll-like receptors (TLRs) have been revealed to be critical for the recognition of pathogenic microorganism including Mycobacterium; the present study revealed that NOD-like receptors and C-type lectin receptors are responsible for the TLR-independent recognition of Mycobacterium. The mode of action of NLRP3 protein plays a critical role for causing the tuberculosis disease. The inactive NLRP3 is activated by CARD like ASC protein. This complex is carried out in two processes, one is inflammation process and another one pyronecrosis (cell death) leads causing the tuberculosis. The main objective of this paper is to design a small potent drug to block the second pathway (pyronecrosis) through 'Molecular Docking approach' by using the In silico tools

Synthesis and cytotoxic activity of sulfur linked mono / bis heterocycles

1173-1178A variety of sulfur linked mono / bis heterocycles have been prepared and their cytotoxic activity on A549 lung adenocarcinoma cells studied. The imidazolyl and benzimidazolyl thiadiazoles (7c, 8c) display appreciable cytotoxic activity against A549 cells

Synthesis, antioxidant, and cytotoxic activities of bis(oxazolyl/thiazolyl/imidazolyl)amidomethanesulfonyl Acetamides

A new class of bis(oxazolyl/thiazolyl/imidazolyl)amidomethanesulfonyl acetamides was prepared from the respective (oxazolyl/thiazolyl/imidazolyl)carbamoyl-methylthio acetic acid and studied their antioxidant activity and cytotoxic activitity against A549 lung adenocarcinoma cells. The methyl-substituted sulfonyl bisoxazoles exhibited excellent radical scavenging activity. On the other hand, the chloro-substituted sulfonyl bisthiazoles (IC50 = 49 A mu M) and sulfonyl bisimidazoles (IC50 = 24 A mu M) showed noticeable cytotoxic activity on A549 cells

Temperature driven development of the rice brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae)

Temperature driven development of rice brown planthopper (BPH), Nilaparvata lugens (Stål) (Hemiptera: Delphacidae) population (biotype 4) was examined at seven constant temperatures (15, 18, 20, 25, 30, 32 and 35°C). Complete development of BPH from egg to adult was observed at constant temperatures ranging from 15 to 32°C with linear development observed till 30°C. Total immature developmental duration decreased from 74.4 days at 15°C to 22.4 days at 30°C. Linear and non-linear models fitted to describe developmental rates of life stages as a function of temperature, gave estimates of bioclimatic thresholds (lower, optimum and upper temperature thresholds). Thermal constants estimated from Campbell linear model for egg, nymph and cumulative immature development to adult were, 198.8, 275.5 and 473.9 degree days, respectively. Among empirical non-linear models, Lactin 2 model was selected for estimates of upper temperature threshold at 35°C based on higher coefficient of determination. Application of thermodynamic SSI model explained the observed nonlinear relationship of development of BPH life stages at temperatures higher than 30°C. The estimated thermal constants and bioclimatic thresholds were used in developing temperature dependent phenology model based on Campbell equation. Phenology model predicted closely the occurrence of different life stages of BPH with those observed under field conditions.

Synthesis, Antioxidant, and Cytotoxic Activities of N-Azole Substituted Thiomorpholine Derivatives

A new class of N-azole substituted thiomorpholine derivatives were prepared and their antioxidant and cytotoxic activities were studied. The methyl substituted oxazolyl thiomorpholine dioxide 9b exhibited radical scavenging activity greater than the standard ascorbic acid. On the other hand, the thiazolyl thiomorpholine 10c having a chloro substituent on the aromatic ring was identified as a remarkable lead molecule for cytotoxic activity against A549 and HeLa cells, with IC50 values of 10.1 and 30.0 mu M, respectively

Synthesis, antimicrobial and cytotoxic activities of pyrimidinyl benzoxazole, benzothiazole and benzimidazole

A variety of pyrimidinyl benzoxazoles, benzothiazoles and benzimidazoles linked by thio, methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic activities. The compound pyrimidinyl bis methylthio benzimidazole 22 was a potent antimicrobial agent particularly against Staphylococcus aureus (29 mm, MIC 12.5 mu g/mL) and Penicillium chrysogenum (38 mm, MIC 12.5 mu g/mL). The amino linked pyrimidinyl bis benzothiazole 24 exhibited cytotoxic activity on A549 cells with IC50 value of 10.5 mu M. (C) 2014 Elsevier Masson SAS. All rights reserved

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Not AvailableTemperature driven development of rice brown planthopper (BPH), Nilaparvata lugens (Stål) (Hemiptera: Delphacidae) population (biotype 4) was examined at seven constant temperatures (15, 18,20, 25, 30, 32 and 35°C). Complete development of BPH from egg to adult was observed at constant temperatures ranging from 15 to 32°C with linear development observed till 30°C. Total immature developmental duration decreased from 74.4 days at 15°C to 22.4 days at 30°C. Linear and non-linear models fitted to describe developmental rates of life stages as a function of temperature, gave estimates of bioclimatic thresholds (lower, optimum and upper temperature thresholds). Thermal constants estimated from Campbell linear model for egg, nymph and cumulative immature development to adult were, 198.8, 275.5 and 473.9 degree days, respectively. Among empirical non-linear models, Lactin 2 model was selected for estimates of upper temperature threshold at 35°C based on higher coefficient of determination. Application of thermodynamic SSI model explained the observed nonlinear relationship of development of BPH life stages at temperatures higher than 30°C. The estimated thermal constants and bioclimatic thresholds were used in developing temperature dependent phenology model based on Campbell equation. Phenology model predicted closely the occurrence of different life stages of BPH with those observed under field conditions.Not Availabl